Protein Alignment IGF2BP1 and PBP2

DIOPT Version :10

• Sequence 1: NP_006537.3
• Gene: IGF2BP1 / 10642
• HGNCID: 28866
• Length: 577
• Species: Homo sapiens
• Sequence 2: NP_009792.3
• Gene: PBP2 / 852533
• SGDID: S000000437
• Length: 413
• Species: Saccharomyces cerevisiae
• Alignment Length: 399
• Identity: 88/399 - (22%)
• Similarity: 168/399 - (42%)
• Gaps: 71/399 - (17%)

Human   195 DIPLRLLVPTQYVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKAISVHSTPEGCSSACKM 259
            |:.||:|...::...|:|.:||||..|..:|.::|::..... |..|:.:.|..|.:..:.|..|
Yeast    66 DVHLRMLCLVKHASLIVGHKGATISRIKSETSARINISNNIR-GVPERIVYVRGTCDDVAKAYGM 129

Human   260 ILEIMHKE--AKDTKTADEVPLKILAHNNFVGRLIGKEGRNLKKVEQDTETKITISSLQDLTLYN 322
            |:..:.:|  .:|.....|:.:.:|..::.:|.:|||.|..|:::|..:..|: .:|...|.|.|
Yeast   130 IVRALLEEHGNEDNGEDIEISINLLIPHHLMGCIIGKRGSRLREIEDLSAAKL-FASPNQLLLSN 193

Human   323 PERTITVKGAIENCCRAEQEIMKKVREAYENDVAAMSLQSHLI------PGLNL-AAVGLFPASS 380
             :|.:|:.|               |.:|..  :|...:...|:      |..|: .::...|...
Yeast   194 -DRILTING---------------VPDAIH--IATFYISQTLLNFQMESPQKNVKRSIYYQPTQF 240

Human   381 SAVPPPPSSVTGAAPYSSFMQAPEQEMVQVFIPAQAVGAIIGKKGQHIKQ--LS----RFASASI 439
            ::|     .:..:.|.:.|.|...|     :.|:..:.:....|...|..  ||    ::.:||:
Yeast   241 NSV-----LIDHSQPNTIFHQRNHQ-----YHPSDKLLSYKPNKNLPISSTLLSMATPQYTTASV 295

Human   440 KIAPPETPDSKV-RMVIITGPPEAQFKAQGRIYGKLKEENFFGPKEEVKLETHIRVPASAAGRVI 503
            ..|....|:..: .:.::.||..:.......:...:::|.|...|              ..|.||
Yeast   296 ANATAFQPNFVIPNVTVLDGPVISPAPGNHLLMNFVQQEIFIDEK--------------FVGNVI 346

Human   504 GKGGKTVNELQNLTAAEVVVPRDQTPDE-NDQVIVKIIGHFYASQMAQRKIRDILAQVKQQHQKG 567
            ||.||.:|.::..|...:::   |.|.| :.:..:.|.|.|.|||.|       :..:..:.:..
Yeast   347 GKDGKHINSVKESTGCSIII---QDPVEGSSERRLTIRGTFMASQAA-------IMLISNKIEID 401

Human   568 QSNQAQARR 576
            :||..:.||
Yeast   402 RSNAERKRR 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IGF2BP1	NP_006537.3	RRM1_IGF2BP1	1..77	CDD:241069
		RRM2_IGF2BP1	81..156	CDD:410037
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..190
		KH-I_IGF2BP1_rpt1	197..272	CDD:411918	21/76 (28%)
		KH-I_IGF2BP1_rpt2	273..369	CDD:411921	22/101 (22%)
		Sufficient for nuclear export	310..324		4/13 (31%)
		KH-I_IGF2BP1_rpt3	404..479	CDD:411924	13/81 (16%)
		Sufficient for nuclear export	485..495		0/9 (0%)
		KH-I_IGF2BP1_rpt4	487..562	CDD:411927	19/75 (25%)
PBP2	NP_009792.3	KH-I_PCBP_rpt1	69..137	CDD:411866	19/68 (28%)
		KH-I_Rnc1_rpt2	150..218	CDD:411884	19/86 (22%)
		KH-I	334..394	CDD:411802	22/83 (27%)