Protein Alignment IGF2BP1 and mub

DIOPT Version :10

• Sequence 1: NP_006537.3
• Gene: IGF2BP1 / 10642
• HGNCID: 28866
• Length: 577
• Species: Homo sapiens
• Sequence 2: NP_001246875.1
• Gene: mub / 40436
• FlyBaseID: FBgn0262737
• Length: 573
• Species: Drosophila melanogaster
• Alignment Length: 430
• Identity: 92/430 - (21%)
• Similarity: 165/430 - (38%)
• Gaps: 89/430 - (20%)

Human   181 SPVAAGAPAKQQ--QVDIPLRLLVPTQYVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKA 243
            |..|.||..|.:  .|.:.:||::..:.||:||||:|..:....:::.:||::   .:....|:.
  Fly     7 SSSAGGASIKHEDPSVTLTIRLIMQGKEVGSIIGKKGEIVNRFREESGAKINI---SDGSCPERI 68

Human   244 ISVHSTPEGCSSACKMILEIMHK-------EAKDTKTADEVPLKILAHNNFVGRLIGKEGRNLKK 301
            ::|..|.....||..:|.:...:       ..|..||  ::|::::...:..|.||||.|..:|:
  Fly    69 VTVSGTTNAIFSAFTLITKKFEEWCSQFNDVGKVGKT--QIPIRLIVPASQCGSLIGKSGSKIKE 131

Human   302 VEQDTETKITISSLQDLTLYNPERTITVKGAIENCCRAEQEIMKKVREAYENDVAAMSLQSHLIP 366
            :.|.|...|.::|  ::...:.||.:|:.|:.|...:...:|...:.|:
  Fly   132 IRQTTGCSIQVAS--EMLPNSTERAVTLSGSAEQITQCIYQICLVMLES---------------- 178

Human   367 GLNLAAVGLFPASSSAVP-PPPSSVTG--------AAPYSSFMQAPEQEMVQVFIPAQAVGAIIG 422
                      |...:.:| .|...|||        |.........|.||...||..|.|.|.:..
  Fly   179 ----------PPRGATIPYRPKPQVTGPVILANGQAFTIQGNYAVPTQETCPVFPLALATGGLHA 233

Human   423 ---------KKGQHIKQLSRFASASIKIAPPETPDSKVRMVIITGPPEAQFKAQGRIYGKLKEEN 478
                     .||.|::.           |.|.......:|..:...|.|...|.|  ...:...:
  Fly   234 GISGLADPLLKGAHLQG-----------AIPAHHHHLQQMPDVAKNPLASLAALG--LAGMNPAS 285

Human   479 FFG------PKEEVKLETH-IRVPASAAGRVIGKGGKTVNELQNLTAAEVVVPR-DQTPDENDQV 535
            ..|      |....:.:.| :.|.....|.:|||||..:.|::.::.|.:.:.. ::....|...
  Fly   286 TGGINHTANPANRAQQQQHEMTVSNDLIGCIIGKGGTKIAEIRQISGAMIRISNCEEREGGNTDR 350

Human   536 IVKIIGHFYASQMAQRKIR--------DILAQVKQQHQKG 567
            .:.|.|:..:..:||..|.        ::|.|.:.|...|
  Fly   351 TITISGNPDSVALAQYLINMSVELQKANLLEQAQSQQNGG 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IGF2BP1	NP_006537.3	RRM1_IGF2BP1	1..77	CDD:241069
		RRM2_IGF2BP1	81..156	CDD:410037
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..190		4/8 (50%)
		KH-I_IGF2BP1_rpt1	197..272	CDD:411918	18/81 (22%)
		KH-I_IGF2BP1_rpt2	273..369	CDD:411921	20/95 (21%)
		Sufficient for nuclear export	310..324		2/13 (15%)
		KH-I_IGF2BP1_rpt3	404..479	CDD:411924	17/83 (20%)
		Sufficient for nuclear export	485..495		1/10 (10%)
		KH-I_IGF2BP1_rpt4	487..562	CDD:411927	18/84 (21%)
mub	NP_001246875.1	KH-I_PCBP_rpt1	26..92	CDD:411866	17/68 (25%)
		KH-I_PCBP_rpt2	107..177	CDD:411806	18/71 (25%)
		KH-I_PCBP_rpt3	301..371	CDD:411867	16/69 (23%)