Protein Alignment IGF2BP1 and Psi

DIOPT Version :10

• Sequence 1: NP_006537.3
• Gene: IGF2BP1 / 10642
• HGNCID: 28866
• Length: 577
• Species: Homo sapiens
• Sequence 2: NP_995862.1
• Gene: Psi / 36889
• FlyBaseID: FBgn0014870
• Length: 797
• Species: Drosophila melanogaster
• Alignment Length: 491
• Identity: 96/491 - (19%)
• Similarity: 165/491 - (33%)
• Gaps: 162/491 - (32%)

Human   165 NGRRGGFGSRGQP---------RQGSPVA------AGAPAKQQQVDIPLRLLVPTQYVGAIIGK- 213
            :|..||.|..|.|         .|.:.||      ||...::|     :||  |....||.:|:
  Fly    83 SGSGGGGGGGGGPGGASITQAIAQAAAVAARLAASAGTSCEEQ-----IRL--PESVAGAFMGRS 140

Human   214 EGATIRNITKQTQSKIDVHRKEN---------------------------AGAAEKAISVHSTPE 251
            ...||.:|..::..|:.|.:.::                           .|..|..::::..|.
  Fly   141 SNDTITHIQAESGVKVQVMQDQDRVIMLRGQRDTVTKGREMIQNMANRAGGGQVEVLLTINMPPP 205

Human   252 GCSSACKMILEIMHKEAKDTKTADEVPLKILAHNNFVGRLIGKEGRNLKKVEQDTETKITISSLQ 316
            | .|......|||...||                  ||.:|||.|..:|::::.|..|:.|  :|
  Fly   206 G-PSGYPPYQEIMIPGAK------------------VGLVIGKGGDTIKQLQEKTGAKMII--IQ 249

Human   317 DLTLYNPERTITVKGAIENCCRAEQEIMKKVREAYENDVAAMSLQSHLIPGLNLAAVGLFPASSS 381
            |.......:.:.:.|..:....|:|.::        :.:|....|.....|......|..|...
  Fly   250 DGPNQELIKPLRISGEAQKIEHAKQMVL--------DLIAQKDAQGQQQGGRGGGGGGGGPGMG- 305

Human   382 AVPPPPSSVTGAAPYSSFMQAPEQEMVQVFIPAQAVGAIIGKKGQHIKQLSRFASASIKIAPPET 446
                          :::|......|..:||:|..|||.:|||.|..|:::.......::....:.
  Fly   306 --------------FNNFNNGNGGESTEVFVPKIAVGVVIGKGGDMIRKIQTECGCKLQFIQGKN 356

Human   447 PDSKVRMVIITGPPEAQFKAQGRIYGKLKEENFF------------------------------- 480
            .:...|..:|.|..:....|:..|.|.:  ||..
  Fly   357 DEMGDRRCVIQGTRQQVDDAKRTIDGLI--ENVMQRNGMNRNGNGGGGGPGGDSGNSNYGYGYGV 419

Human   481 ----GPKEEVKLETHIRVPASAAGRVIGKGGKTVNELQNLTAAEVVVPRDQTPDENDQVIVKIIG 541
                |.:||:.    ..||||..|.|||:||:|:..:...:.|...:.|:.:...|:::.
  Fly   420 NHAQGGREEIT----FLVPASKCGIVIGRGGETIKLINQQSGAHTEMDRNASNPPNEKLF----- 475

Human   542 HFYASQMAQRKIRDILAQVKQQHQKGQSNQAQARRK 577
                                  ..||.::|.:|.|:
  Fly   476 ----------------------KSKGTTDQVEAARQ 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IGF2BP1	NP_006537.3	RRM1_IGF2BP1	1..77	CDD:241069
		RRM2_IGF2BP1	81..156	CDD:410037
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..190		11/39 (28%)
		KH-I_IGF2BP1_rpt1	197..272	CDD:411918	21/102 (21%)
		KH-I_IGF2BP1_rpt2	273..369	CDD:411921	18/95 (19%)
		Sufficient for nuclear export	310..324		3/13 (23%)
		KH-I_IGF2BP1_rpt3	404..479	CDD:411924	19/74 (26%)
		Sufficient for nuclear export	485..495		1/9 (11%)
		KH-I_IGF2BP1_rpt4	487..562	CDD:411927	14/74 (19%)
Psi	NP_995862.1	KH_1	123..184	CDD:459630	12/67 (18%)
		KH-I_FUBP_rpt2	214..280	CDD:411825	20/93 (22%)
		KH-I_FUBP_rpt3	317..384	CDD:411826	17/66 (26%)
		KH-I_FUBP_rpt4	428..494	CDD:411827	20/93 (22%)
		DUF1897	591..619	CDD:462653
		DUF1897	<653..680	CDD:462653