Protein Alignment IGF2BP1 and Imp

DIOPT Version :10

• Sequence 1: NP_006537.3
• Gene: IGF2BP1 / 10642
• HGNCID: 28866
• Length: 577
• Species: Homo sapiens
• Sequence 2: NP_001245616.1
• Gene: Imp / 32009
• FlyBaseID: FBgn0285926
• Length: 638
• Species: Drosophila melanogaster
• Alignment Length: 544
• Identity: 216/544 - (39%)
• Similarity: 319/544 - (58%)
• Gaps: 59/544 - (10%)

Human    67 RLEIEHSVPKKQRSRKIQIRNIPPQLRWEVLDSLLAQYGTVENCEQVNTESE-TAVVNVTYSNRE 130
            |.::|.:......:.||.|..||.|.|:|.::.||..||.|:.||.::::.: |..|::|:.|.|
  Fly    28 RQQLEGAGTSSVTTSKILISGIPMQTRFEDIEPLLKPYGIVKQCEAISSKDQNTQTVHITFENPE 92

Human   131 QTRQAIMKLNGHQLENHALKVSYIPDEQIAQGPENGRRGGFGSRGQPRQGSPVAAGAPAKQQQVD 195
            |.::|.:.|||.:.|...|....:...|              .|.|..|.:|. .|.|...:|.|
  Fly    93 QAQRAAVGLNGVEFEGSKLHAEQLDKNQ--------------RRSQRNQRNPY-PGMPGPGRQAD 142

Human   196 IPLRLLVPTQYVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKAISVHSTPEGCSSACKMI 260
            .|||:||.::.||||||::|:|||.||:|:::::|||||||.|:.||:|:::..||.|::|||.|
  Fly   143 FPLRILVQSEMVGAIIGRQGSTIRTITQQSRARVDVHRKENVGSLEKSITIYGNPENCTNACKRI 207

Human   261 LEIMHKEAKDTKTAD------EVPLKILAHNNFVGRLIGKEGRNLKKVEQDTETKITISSLQDLT 319
            ||:|.:||..|...:      |:.||||||||.:||:|||.|..:|::.|||:||||:||:.|:.
  Fly   208 LEVMQQEAISTNKGELSPECSEICLKILAHNNLIGRIIGKSGNTIKRIMQDTDTKITVSSINDIN 272

Human   320 LYNPERTITVKGAIENCCRAEQEIMKKVREAYENDVAAMSLQSHLIPGLNLAAVGLFPAS----S 380
            .:|.||.|||||.|||..|||.:|..|:|::||||:.||:.||.:.|||:..|:...|.:    :
  Fly   273 SFNLERIITVKGLIENMSRAENQISTKLRQSYENDLQAMAPQSLMFPGLHPMAMMSTPGNGMVFN 337

Human   381 SAVPPP-----PSSVTGAAPYSSFMQAPEQEMVQVFIPAQAVGAIIGKKGQHIKQLSRFASASIK 440
            :::|.|     ..|.|.|:..........||...::||..|||||||.:|.||:.:.||::||:|
  Fly   338 TSMPFPSCQSFAMSKTPASVVPPVFPNDLQETTYLYIPNNAVGAIIGTRGSHIRSIMRFSNASLK 402

Human   441 IAPPETP---DSKV-RMVIITGPPEAQFKAQGRIYGKLKEENFFGPKEEVKLETHIRVPASAAGR 501
            |||.:..   |.:. |.|.|.|.||.|:|||..|:.|::||.|....::|:|...:.|.:|..||
  Fly   403 IAPLDADKPLDQQTERKVTIVGTPEGQWKAQYMIFEKMREEGFMCGTDDVRLTVELLVASSQVGR 467

Human   502 VIGKGGKTVNELQNLTAAEVVVPR----------DQTPDENDQVIVKIIGHFYASQMAQRKIRDI 556
            :|||||:.|.|||.:|.:.:.:|.          ::||       |.|||.||:.|.|||:||.:
  Fly   468 IIGKGGQNVRELQRVTGSVIKLPEHALAPPSGGDEETP-------VHIIGLFYSVQSAQRRIRAM 525

Human   557 LAQV-------KQQHQKGQSNQAQ 573
            :...       ||:..|.|..|.|
  Fly   526 MLSTNPPPITKKQKAAKEQLQQQQ 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IGF2BP1	NP_006537.3	RRM1_IGF2BP1	1..77	CDD:241069	2/9 (22%)
		RRM2_IGF2BP1	81..156	CDD:410037	27/75 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..190		6/29 (21%)
		KH-I_IGF2BP1_rpt1	197..272	CDD:411918	41/74 (55%)
		KH-I_IGF2BP1_rpt2	273..369	CDD:411921	53/101 (52%)
		Sufficient for nuclear export	310..324		6/13 (46%)
		KH-I_IGF2BP1_rpt3	404..479	CDD:411924	37/78 (47%)
		Sufficient for nuclear export	485..495		2/9 (22%)
		KH-I_IGF2BP1_rpt4	487..562	CDD:411927	30/91 (33%)
Imp	NP_001245616.1	RRM2_VICKZ	42..118	CDD:409794	27/75 (36%)
		KH-I_IGF2BP_rpt1	144..211	CDD:411828	38/66 (58%)
		KH-I_IGF2BP_rpt2	231..302	CDD:411829	41/70 (59%)
		KH-I_IGF2BP_rpt3	368..437	CDD:411830	32/68 (47%)
		KH-I_IGF2BP_rpt4	455..523	CDD:411831	27/74 (36%)