Protein Alignment IGF2BP1 and imph-1

DIOPT Version :10

• Sequence 1: NP_006537.3
• Gene: IGF2BP1 / 10642
• HGNCID: 28866
• Length: 577
• Species: Homo sapiens
• Sequence 2: NP_001263700.1
• Gene: imph-1 / 175595
• WormBaseID: WBGene00010908
• Length: 854
• Species: Caenorhabditis elegans
• Alignment Length: 647
• Identity: 161/647 - (24%)
• Similarity: 268/647 - (41%)
• Gaps: 154/647 - (23%)

Human    64 QGKRLEIEHSVPKKQRSRKI------QIRNIPPQLRWEVLDSLLAQYGTVENCEQVNTESETAV- 121
            ||.|.:....:.::|:|.:.      |::.:..|...::...|   .|...|.:|......|.:
 Worm   159 QGARQQHPQQMQQQQQSNQSAHFMHQQLQAVQQQQAQQMHHRL---QGAPINPQQFMVPPPTMMQ 220

Human   122 -VNVTYSNREQTRQAIMKLNGHQ-----LENHALKVSYIPDEQIAQ---GPENGRRGGFGSRGQP 177
             ..:..:.::|.:|.......||     ::.|| :..|.|.:|..|   |..........:..|.
 Worm   221 PQQMQQAQQQQAQQMHQMQIHHQQHPQMMQQHA-QQGYHPHQQNQQHQAGQHQQSHHQSQNHNQH 284

Human   178 RQGSPVAAGAPAKQQQV--------DIPLRLLVPTQYVGAIIGKEGATIRNITKQTQSKID---V 231
            |..:...:|.....|.:        |.|:|.:|..:|...|||..|:||::|...|:.::|   :
 Worm   285 RNHNQSHSGPHHIPQNLMMPRCMLKDWPIRCVVEGKYHAVIIGPNGSTIKDIASSTRCRVDFVNL 349

Human   232 HRKENA--GAAEKAISVHSTPEGCSSACKMILEIMHKEA--KDTKTADEVPLKILAHNNFVGRLI 292
            .:||..  |..::.::||...|..:.|...||:::..||  .|.....:..|::.|||...||||
 Worm   350 SKKERTVLGNNDRILTVHGVAEQATKAVARILDVIQSEAVKDDVNVGADTVLRMRAHNQLCGRLI 414

Human   293 GKEGRNLKKVEQDTETKITIS-------SLQDLT----LYNPERTITVKG-AIENCCRAEQEIMK 345
            ||.|.::|::.|.|.|.||::       .:..||    |...||||.|:| :||...:||..|..
 Worm   415 GKAGSSIKEIMQKTGTNITVTKYIEPPGGISGLTANELLGLMERTIMVRGPSIEAVVQAEALISA 479

Human   346 KVREAYEND--VAAMSLQSHLIPGLNLAAVGLFP--ASSSAVP-----PPPSSVTGAAPY----- 396
            |:::.||:|  :.|.|:|..:.|   :....:.|  ||||||.     |.|..|.....:
 Worm   480 KLKKCYESDSQLRAQSMQCPMPP---MMMPPILPPGASSSAVSAPHFIPTPVGVMQVQHFASSQH 541

Human   397 -------SSFMQ---------APEQEMVQVFIPAQAVGAIIGKKGQHIKQLSRFASASIKIAPPE 445
                   :||:|         ......|::::|...:||:||.||::||.:.|...||:||..||
 Worm   542 LVHQNANNSFLQPGVLQIQPGTTNLRQVRMWVPDSMIGALIGAKGKNIKMIIRDTGASVKIEAPE 606

Human   446 ----------------------------------------------------TPDSKVRMVIITG 458
                                                                .|.|: |||.|.|
 Worm   607 EKTQREAEEAEKKRKLDETDSGCEGVASGDHPQEFLEDNATINSSDAIEEKPKPVSE-RMVTING 670

Human   459 PPEAQFKAQGRIYGKLKEENFFGP--------KEEVKLETHIRVPASAAGRVIGKGGKTVNELQN 515
            ......|||..::.|:.|.:...|        ...:::.|.:.||....||:|||||:.|.|||.
 Worm   671 DDLQLLKAQSYVFSKIAETSSSLPSSGMDGDRSHMLRIRTEVSVPTRIIGRIIGKGGQNVRELQR 735

Human   516 LTAAEVVVPRDQTPD----------ENDQVIVKIIGHFYASQMAQRKIRDILAQVKQQHQKG 567
            :|.|.|.:|.::...          |.|..:::.||:.|::...|.::..:   |.:.::.|
 Worm   736 ITGAVVKIPEEERNGGEVYRHDDGLEEDMTMIRTIGNMYSTHNVQFRLAHL---VNEYYRSG 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IGF2BP1	NP_006537.3	RRM1_IGF2BP1	1..77	CDD:241069	3/12 (25%)
		RRM2_IGF2BP1	81..156	CDD:410037	14/87 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..190		5/32 (16%)
		KH-I_IGF2BP1_rpt1	197..272	CDD:411918	25/81 (31%)
		KH-I_IGF2BP1_rpt2	273..369	CDD:411921	39/109 (36%)
		Sufficient for nuclear export	310..324		5/24 (21%)
		KH-I_IGF2BP1_rpt3	404..479	CDD:411924	29/126 (23%)
		Sufficient for nuclear export	485..495		1/9 (11%)
		KH-I_IGF2BP1_rpt4	487..562	CDD:411927	25/84 (30%)
imph-1	NP_001263700.1	KH	313..384	CDD:197652	21/70 (30%)
		KH-I_IGF2BP_rpt2	400..483	CDD:411829	32/82 (39%)
		KH-I	569..>612	CDD:469614	17/42 (40%)
		KH-I	709..783	CDD:469614	24/73 (33%)