Protein Alignment RGS14 and Rgs14

DIOPT Version :10

• Sequence 1: XP_047272594.1
• Gene: RGS14 / 10636
• HGNCID: 9996
• Length: 619
• Species: Homo sapiens
• Sequence 2: NP_001347643.1
• Gene: Rgs14 / 51791
• MGIID: 1859709
• Length: 551
• Species: Mus musculus
• Alignment Length: 622
• Identity: 460/622 - (73%)
• Similarity: 480/622 - (77%)
• Gaps: 86/622 - (13%)

Human     1 MPGKPKHLGVPNGRMVLAVSDGELSSTTGPQGQGEGRGSSLSIHSLPSGPSSPFPTEEQPVASWA 65
            ||||||||||||||||||||||||:||.|.|.||||||||||||||||||||||.||||||||||
Mouse     1 MPGKPKHLGVPNGRMVLAVSDGELTSTAGSQAQGEGRGSSLSIHSLPSGPSSPFSTEEQPVASWA 65

Human    66 LSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTQQLAQEARNIYQEFLSSQA 130
            .|||||||||.|||||||||||||||||||||||||||||||||||:||||||.|||.|||||||
Mouse    66 QSFERLLQDPRGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTKQLAQEAHNIYHEFLSSQA 130

Human   131 LSPVNIDRQAWLGEEVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRECLLAEAEGRPLRE 195
            ||||||||||||.|||||:|||||||||||||||||||||||||||||||:||||||||||||||
Mouse   131 LSPVNIDRQAWLSEEVLAQPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYQECLLAEAEGRPLRE 195

Human   196 PGSSRLGSPDATRKVRGTGRGTGRGRGSCGPRARGDASGCRSASLCPRSACGLGPSPVPAPPLYP 260
            ||||.|||||..||
Mouse   196 PGSSHLGSPDTARK--------------------------------------------------- 209

Human   261 QKPKLKPGKSLPLGVEELGQLPPVEGPGGRPLRKSFRREL-GGTANAALRRESQGSLNSSASLDL 324
             |||||||||||||||||||||..|||.|||||||||||: ||..|:||||||||||||||||||
Mouse   210 -KPKLKPGKSLPLGVEELGQLPLAEGPCGRPLRKSFRREMTGGAMNSALRRESQGSLNSSASLDL 273

Human   325 GFLAFVSSKSESHRKSLGSTEGESESRPGKYCCVYLPDGTASLALARPGLTIRDMLAGICEKRGL 389
            |||||||||||||||||||.|.|||||||||||||||||||||||||||||||||||||||||||
Mouse   274 GFLAFVSSKSESHRKSLGSGESESESRPGKYCCVYLPDGTASLALARPGLTIRDMLAGICEKRGL 338

Human   390 SLPDIKVYLVGNEQKALVLDQDCTVLADQEVRLENRITFELELTALERVVRISAKPTKRLQEALQ 454
            |||||||||||||||||||||||||||||||||||||||:|||..||||||||||||||||||||
Mouse   339 SLPDIKVYLVGNEQKALVLDQDCTVLADQEVRLENRITFQLELVGLERVVRISAKPTKRLQEALQ 403

Human   455 PILEKHGLSPLEVVLHRPGEKQPLDLGKLVSSVAAQRLVLDTLPGVKISKARDKSPCRSQGCPPR 519
            |||.|||||..:|||||||||||:||...|||||:|.|||||.|..|:|:||..||||||||.||
Mouse   404 PILAKHGLSLDQVVLHRPGEKQPMDLENPVSSVASQTLVLDTPPDAKMSEARSISPCRSQGCLPR 468

Human   520 TQDKATHPPPASPSSLVKVPSSATGKRQTCDIEGLVELLNRVQSSGAHDQRGLLRKEDLVLPEFL 584
            ||.|.:|.||:|.|.||:..||:||.||||||||  .|......||| :||
Mouse   469 TQTKDSHLPPSSSSLLVEDASSSTGNRQTCDIEG--ALPGGAAESGA-EQR-------------- 516

Human   585 QLPAQGPSSEET-------PPQTKSAAQP----IGGS 610
                 ||.||.|       |.:..:|:.|    .|||
Mouse   517 -----GPRSERTSSQRGPGPSRISAASFPKTRLSGGS 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RGS14	XP_047272594.1	RGS_RGS14	58..186	CDD:188697	119/127 (94%)
		RBD1_RGS14	354..424	CDD:340657	69/69 (100%)
		RBD2_RGS14	425..496	CDD:340659	57/70 (81%)
		GoLoco	552..573	CDD:460481	8/20 (40%)
Rgs14	NP_001347643.1	RGS_RGS14	58..186	CDD:188697	119/127 (94%)
		RBD1_RGS14	303..373	CDD:340657	69/69 (100%)
		RBD2_RGS14	374..446	CDD:340659	58/71 (82%)