Protein Alignment RGS14 and Rgs14

DIOPT Version :10

• Sequence 1: XP_047272594.1
• Gene: RGS14 / 10636
• HGNCID: 9996
• Length: 619
• Species: Homo sapiens
• Sequence 2: NP_446216.1
• Gene: Rgs14 / 114705
• RGDID: 620003
• Length: 544
• Species: Rattus norvegicus
• Alignment Length: 599
• Identity: 476/599 - (79%)
• Similarity: 495/599 - (82%)
• Gaps: 56/599 - (9%)

Human     1 MPGKPKHLGVPNGRMVLAVSDGELSSTTGPQGQGEGRGSSLSIHSLPSGPSSPFPTEEQPVASWA 65
            ||||||||||||||||||||||||:||:|.|.||||||||||||||||||||||.|:||||||||
  Rat     1 MPGKPKHLGVPNGRMVLAVSDGELTSTSGSQAQGEGRGSSLSIHSLPSGPSSPFSTDEQPVASWA 65

Human    66 LSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTQQLAQEARNIYQEFLSSQA 130
            .|||||||||.|||||||||||||||||||||:|||||||||||||:||||||.|||.|||||||
  Rat    66 QSFERLLQDPRGLAYFTEFLKKEFSAENVTFWQACERFQQIPASDTKQLAQEAHNIYHEFLSSQA 130

Human   131 LSPVNIDRQAWLGEEVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRECLLAEAEGRPLRE 195
            ||||||||||||.|||||:|||||||||||||||||||||||||||||||:||||||||||||||
  Rat   131 LSPVNIDRQAWLSEEVLAQPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYQECLLAEAEGRPLRE 195

Human   196 PGSSRLGSPDATRKVRGTGRGTGRGRGSCGPRARGDASGCRSASLCPRSACGLGPSPVPAPPLYP 260
            ||||.|||||..||
  Rat   196 PGSSHLGSPDTARK--------------------------------------------------- 209

Human   261 QKPKLKPGKSLPLGVEELGQLPPVEGPGGRPLRKSFRREL-GGTANAALRRESQGSLNSSASLDL 324
             |||||||||||||||||||||..|   |||||||||||: ||..|:||||||||||||||||||
  Rat   210 -KPKLKPGKSLPLGVEELGQLPLAE---GRPLRKSFRREMPGGAVNSALRRESQGSLNSSASLDL 270

Human   325 GFLAFVSSKSESHRKSLGSTEGESESRPGKYCCVYLPDGTASLALARPGLTIRDMLAGICEKRGL 389
            |||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||
  Rat   271 GFLAFVSSKSESHRKSLGSGEGESESRPGKYCCVYLPDGTASLALARPGLTIRDMLAGICEKRGL 335

Human   390 SLPDIKVYLVGNEQKALVLDQDCTVLADQEVRLENRITFELELTALERVVRISAKPTKRLQEALQ 454
            |||||||||||.|||||||||||||||||||||||||||:|||..||||||||||||||||||||
  Rat   336 SLPDIKVYLVGKEQKALVLDQDCTVLADQEVRLENRITFQLELVGLERVVRISAKPTKRLQEALQ 400

Human   455 PILEKHGLSPLEVVLHRPGEKQPLDLGKLVSSVAAQRLVLDTLPGVKISKARDKSPCRSQGCPPR 519
            |||.|||||..:||||||||||.:||..||||||:|.|||||||..|..:|....|||||||.||
  Rat   401 PILAKHGLSLDQVVLHRPGEKQLVDLENLVSSVASQTLVLDTLPDAKTREASSIPPCRSQGCLPR 465

Human   520 TQDKATHPPPASPSSLVKVPSSATGKRQTCDIEGLVELLNRVQSSGAHDQRGLLRKEDLVLPEFL 584
            ||.|.:|.||.|.|..|:..|.:||||||||||||||||||||||||||||||||||||||||||
  Rat   466 TQTKDSHLPPLSSSLSVEDASGSTGKRQTCDIEGLVELLNRVQSSGAHDQRGLLRKEDLVLPEFL 530

Human   585 QLPAQGPSSEETPP 598
            |||:|.|.|:|.||
  Rat   531 QLPSQRPGSQEAPP 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RGS14	XP_047272594.1	RGS_RGS14	58..186	CDD:188697	118/127 (93%)
		RBD1_RGS14	354..424	CDD:340657	68/69 (99%)
		RBD2_RGS14	425..496	CDD:340659	57/70 (81%)
		GoLoco	552..573	CDD:460481	20/20 (100%)
Rgs14	NP_446216.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..59		33/39 (85%)
		RGS_RGS14	58..186	CDD:188697	118/127 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	191..220		25/80 (31%)
		Necessary for interaction with RABGEF1. /evidence=ECO:0000250	297..424		118/126 (94%)
		RBD1_RGS14	300..370	CDD:340657	68/69 (99%)
		RBD2_RGS14	371..442	CDD:340659	57/70 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..493		23/43 (53%)
		GoLoco	498..519	CDD:460481	20/20 (100%)