Protein Alignment TRIM16 and nhl-1

DIOPT Version :10

• Sequence 1: NP_006461.3
• Gene: TRIM16 / 10626
• HGNCID: 17241
• Length: 564
• Species: Homo sapiens
• Sequence 2: NP_499028.1
• Gene: nhl-1 / 176295
• WormBaseID: WBGene00003597
• Length: 974
• Species: Caenorhabditis elegans
• Alignment Length: 461
• Identity: 89/461 - (19%)
• Similarity: 166/461 - (36%)
• Gaps: 131/461 - (28%)

Human    36 SASPVEEEDVGSSEKLGRE--TEEQDSDSAEQGDPAGEGKEVL-CDFCLDDTRRVKAVKSCLTCM 97
            |:||..|.:  :.||: ||  :....|..|:..:|..:.:::| |..|||..::.|    .|.|.
 Worm     2 SSSPQNEAE--AREKM-RELMSRPPSSRPADFVNPLEKIEQLLTCPICLDRYKQPK----LLPCQ 59

Human    98 VNYC---------------------EEHLQPH------QVNIK----LQSHLLTEP-----VKDH 126
            ..:|                     .||..|:      |.|..    |:.||...|     ::::
 Worm    60 HTFCYPCLESCADTLHRNLKCPECRAEHNIPYDGVKAFQPNYTLTGFLEIHLQATPESAAEIEEY 124

Human   127 NWRY-------CPAHHSPLSAFCCPDQQC---ICQDCCQEHSGHTIVSLDAARRDKEAELQCTQL 181
            ..||       |..     .|.|.|...|   .|::|.|.|       :|..:||....|...:.
 Worm   125 IHRYNLERCKICDE-----KADCEPCAHCDRKACKECRQTH-------MDMLKRDMSRLLNQVKR 177

Human   182 DLERKLKLNENAISRLQANQKSVLVSVSEVKAVAEMQFGELLAAVRKAQANVMLFLEEKEQAALS 246
            ...|..:.::|    |......:.::....||..:..|......::|.:.|.::.::..:.....
 Worm   178 LANRITEASDN----LSKGVDMMTMNCETTKAEIKEYFHRYQRDLKKKEDNFLMEVDTFQATETR 238

Human   247 QANGIKAHLEYRSAEMEKSKQELERMAAISNTVQFLEEYCKFKNTEDITFPSVYVGLKDKLSGIR 311
            ..:.::..||..|:.|.::...|:  |||...       |..:::|              |..::
 Worm   239 NMSNLRDVLEIESSNMSEAVSRLD--AAIKGE-------CSIEDSE--------------LVRMK 280

Human   312 KVITESTVHLIQLLENYKKKLQE-FSKEEEY---DIRTQVSAVVQRKYWTS------KPEPSTR- 365
            ...||.    ::.|.|::....| |:::..:   |...::.|.:.    ||      .|:.|.|
 Worm   281 NTFTEG----LEYLRNFQPDADELFNRKLRFSAGDDAAKLPAAIT----TSGELCVLVPQFSGRY 337

Human   366 ----EQFLQYAYDITFDPDTAHKYLRLQEENR-----KVTNTTPWEH----PYPDLPSRFLHWRQ 417
                :.:|...:.:..:.|:    .|::.:.|     :..:.|...|    |.||..|.....||
 Worm   338 LPLEQSYLPRPFRLPLESDS----YRVKSDERASMRDREADRTSSRHSHRNPEPDESSIRYRRRQ 398

Human   418 VLSQQS 423
            .|..::
 Worm   399 QLEDEA 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRIM16	NP_006461.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..69		10/34 (29%)
		Bbox1_TRIM16	75..122	CDD:380897	17/78 (22%)
		Bbox_SF	129..173	CDD:469587	14/53 (26%)
		CusB_dom_1	<164..>283	CDD:481212	20/118 (17%)
		SPRY_PRY_TRIM16	365..546	CDD:293948	14/73 (19%)
nhl-1	NP_499028.1	RING-HC_NHL-1-like	36..87	CDD:438187	9/54 (17%)
		CC_brat-like	160..261	CDD:475168	17/111 (15%)
		PLN02217	<388..512	CDD:215130	5/17 (29%)
		NHL_TRIM71_like	691..974	CDD:271324
		NHL repeat	715..754	CDD:271324
		NHL repeat	762..800	CDD:271324
		NHL repeat	808..844	CDD:271324
		NHL repeat	852..893	CDD:271324
		NHL repeat	902..932	CDD:271324
		NHL repeat	948..974	CDD:271324