DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CENPE and cenpe

DIOPT Version :9

Sequence 1:NP_001804.2 Gene:CENPE / 1062 HGNCID:1856 Length:2701 Species:Homo sapiens
Sequence 2:NP_001314688.1 Gene:cenpe / 767754 ZFINID:ZDB-GENE-060929-860 Length:2690 Species:Danio rerio


Alignment Length:3045 Identity:896/3045 - (29%)
Similarity:1476/3045 - (48%) Gaps:733/3045 - (24%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAEEGAVAVCVRVRPLNSREES-LGETAQVYWKTDNNVIYQVD----GSKSFNFDRVFHGNETTK 60
            |.||.||.||||||||..||.| ..|..|:||::|...|:|:|    .:||::|||||...|:|.
Zfish     1 MTEESAVKVCVRVRPLIKREASESSEPVQLYWRSDKQAIHQLDEDGAQTKSYSFDRVFSAAESTA 65

Human    61 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKFPDREF 125
            .:|::||.|::.||::||||||||||||:||||:||||||.:.||||.|:.|:|:.||.||.:||
Zfish    66 QLYQDIAKPLVVSAVEGYNGTIFAYGQTSSGKTFTMMGSEHNPGVIPLAMADVFKTIKSFPKKEF 130

Human   126 LLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALKWITKGEKSRH 190
            |||||||||||||:|||||.:.|.|||.|||...:||||||||||:|.:.|.||.|||||||:||
Zfish   131 LLRVSYMEIYNETVTDLLCDSWKRKPLEIREGNYKNVYVADLTEELVTSPEQALSWITKGEKNRH 195

Human   191 YGETKMNQRSSRSHTIFRMILESREKGEPS---NCEGSVKVSHLNLVDLAGSERAAQTGAAGVRL 252
            ||:||||||||||||||||||||||:.:|:   :.:|::.|||||||||||:|||:||||.|.|.
Zfish   196 YGKTKMNQRSSRSHTIFRMILESRERSDPTAGESADGAIIVSHLNLVDLAGAERASQTGAEGARF 260

Human   253 KEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPVSFDETL 317
            |||||||||||.||||||||||....||:|||||||||||||||||||||.|||||||.:.|||:
Zfish   261 KEGCNINRSLFTLGQVIKKLSDESQKGFLNYRDSKLTRILQNSLGGNAKTVIICTITPATVDETV 325

Human   318 TALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEE 382
            :.|||||.||.|||.|:|.|||.:.|||:|||.||:|||::|:|||..|:..|.|::.|.|||:|
Zfish   326 STLQFASAAKRMKNDPHVTEVSDEGALLRRYRNEIVDLKRRLQEVSSVTQTTATERESLCQLLQE 390

Human   383 KDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKI------------------- 428
            ||.||:.|.::|:|||::|||||::.|..::.   ||||||. ||:                   
Zfish   391 KDQLQREQEDRIKNLTKLLVTSSNIALIPKVP---KRRVTWG-GKLLRSAHLLNEDLCSTDMSFA 451

Human   429 -----NKMKNSNYAD----------QFNIP-----------TNITTK-----THKLSINLLREID 462
                 .:..:.:.||          :|:..           ::||.:     :|.|......|:.
Zfish   452 EPYLKKRRADCSLADVGEDMDEFDSRFDFTAMEEPNMDMEMSSITVRSSSEGSHFLDSPRASELM 516

Human   463 ESVCS-ESDVFSNT----------------------------------LDTLSEIE--------- 483
            :.|.| ||.:.:.|                                  .:|:||:|         
Zfish   517 QKVSSLESQLEAETQSKQIAEEMNAELQMKLSHLQNMLEAQSAPSHEEKNTISELEKQMEDLQRR 581

Human   484 -------------------------WNPATKLLNQEN---------------------------- 495
                                     ..|:.:||:.:|                            
Zfish   582 LETEVQERQTAEEKSISLELKVAELEKPSEELLHSQNTCERVKKDLEEAIQLCETVSFEKDAVIA 646

Human   496 -----------IESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQE 549
                       ...||.||:|:.|:|..:.:.|:.:|:.::..::|:.|.||||.||.::|:|.|
Zfish   647 ERDMIKHSLDMTTEELESLKAEKDSLQKEKDALQKDKDALQKDMEERRDADEFEKLEEESKRDYE 711

Human   550 MQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSL 614
            .:|..|.|.|:..:|.:|...|.|:.:|:.....|::|.|...:||.:  |.|            
Zfish   712 RELEAENSRLEKNLKQSEDMIQKLKADLALMSSELQKKTDLTTELQGF--SGK------------ 762

Human   615 ESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAK 679
            :.:::..:::::|.||||::|:.|:|.|||||||:.|||:...|.|.|.:||.::::.|.:||.:
Zfish   763 DIVQEVTRLRRSLDDAETLSLETKKEWAFLRSENISLKERDVTLTTDYGKMEAEVKMLQDRLEQE 827

Human   680 ----KKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALR 740
                ||||.||:|||..||:|.||||:|:||||||:|..|:.||..:.||:|||::..|..::|:
Zfish   828 KSRFKKMQTDLQKELMGAFDENTKLTALMDGKVPKNLTDNVVLEKTVCDLRKELDQIREREQSLQ 892

Human   741 EEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL 805
            .:|   |||::||::|:.|..::...||||..:..|:|.:.|.........|.|.|       |.
Zfish   893 SKV---SELETLPAKVDELLGQVCVVSEELRSVREERDAVCSAQASVNEAHQRLTE-------DY 947

Human   806 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSY 870
            :|.|                       ::::..|::.:..::    ||.|        |..|||.
Zfish   948 STAQ-----------------------HQLLQMESDLLEAQL----KETQ--------LSQELSD 977

Human   871 KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLI--------TEKLQQTLEEVKTL 927
            .||:|.....|....|..:::.:::.|...:.|.:|..|:.|:        :|:||.....:.::
Zfish   978 NTQQLHNMQTENDTLLTSLQEAQQKCEQLSADLASVCAERDLLLSEKMEGESEELQSLRNTISSI 1042

Human   928 TQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKS------- 985
            |:||..::::.:||:.:|||||:|:.:.|.|.|:||.:||:|.|.:|:.|..||.|:|       
Zfish  1043 TEEKQQMQEILQSLREQRDQLKTDLEENVEMMIETQAELRDAQEKVKELQGEINRLESGRVEPDE 1107

Human   986 ---------------KISEEV------------SRNLHMEE-NTG-----ETKDEFQQKMVGIDK 1017
                           :::||:            .|:..||: ||.     |.:.|.|:::..:::
Zfish  1108 QREDGQMDTLHQQIKQLTEELQATVVEKERLLSDRSELMEKMNTDVTSFTEQRSELQERLQQLER 1172

Human  1018 KQD-----LEAK-----NTQTLTADVKDNEIIEQQRKIFSLIQEK-NELQQM------LESVIAE 1065
            ..|     ||.|     ..|:...:.:..:|::|.::.||  :|| :||||:      ||:|:.:
Zfish  1173 DSDTMKTHLEEKEQTILQLQSELQEKQQQQILDQDQQDFS--EEKTDELQQIQTLKEELEAVLEQ 1235

Human  1066 KEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAE------ 1124
            |.||...|:|:.:......||||           .|.:|::.....:..:|....||..      
Zfish  1236 KNQLTLRLEESAQQVCVVSEELR-----------SVREERDAVCSAQASVSEAHQRLTVDYSTAQ 1289

Human  1125 ----------VEEKLKEK--SQQLQEKQQQLLNVQEE-------MSEMQKKINEIE-NLKNELKN 1169
                      :|.:|||.  ||:|.:..|||.|:|.|       :.|.|:|..::. :|.:....
Zfish  1290 HQLLQMESDLLEAQLKETQLSQELSDNTQQLHNMQTENDTLLTSLQETQQKCEQLSADLASVCAE 1354

Human  1170 KELTL-EHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQT 1233
            ::|.| |.||.|..||....|    .:.|||:|::.::|:.:|...:||.|:..:.  ::.|:..
Zfish  1355 RDLLLSEKMEGESEELQSLRN----TISSITEEKQQMQEILQSLREQRDQLKADLE--DSNGMLM 1413

Human  1234 KEELKIAHIHLKEH-----QETIDELRRSVSEKTAQIINTQDLEKSHTK--LQEEIPV-LHEEQE 1290
            :.:|        ||     ....|||.:.:.:...::..|.: ||:..|  |||.:.: :..::|
Zfish  1414 QAQL--------EHGGPQIDTPHDELLQQIQQLREELDATNE-EKNQLKSDLQENVEMTIENQEE 1469

Human  1291 LLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNL- 1354
            |...:.:|.:.|:::.||:  |:|..:|..:.| .::|::||         ||::|:..||:.| 
Zfish  1470 LRAALDKVKDLQKSLEELQ--TKQQESKHKSQL-ELQMQQLR---------EELESVRHERERLL 1522

Human  1355 -----KTIKEALEVKHD-----QLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQF 1409
                 .|..:|.::|.|     :.:|.::.||.::::...:.||::.....|.|:  :.:|.|:.
Zfish  1523 SEHSPNTHTDAEQMKADITSLTEEQEQLQRTLQELRDQLMQTEQTVLQLRADLES--VCAERERL 1585

Human  1410 ---KPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAK 1471
               :.:|     :| ||..:|.||.|          |:|.||:..:.|..:|:||:.:::|....
Zfish  1586 LMDRSRD-----VE-EMEKMSCRLTE----------ERDALQQTVQQLSDQSEQLRRDLEENQDM 1634

Human  1472 HLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFN 1536
            .|:...:|: :.|..:|:         .|:||.:::..:..:|....|.||..:|::.::.||..
Zfish  1635 VLQLRADLQ-SVCAERER---------LLTEKSSDMENLSCRLTEERDALQQTVQQLKDQSEQLR 1689

Human  1537 IKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEA 1601
             :.:.|.|:.|.:|:             ..:||...|....|.|..:::..:.||:|::..:.:|
Zfish  1690 -RDLEENQDMVLQLR-------------ADVESGCAERERLLTERDQDLASITKEREQLLDLLKA 1740

Human  1602 LQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETE 1666
            .:.|::||:                       |.:.|.||.:.   ||:::.|:.....:::.:|
Zfish  1741 NREEKNQLR-----------------------TDLEENQENLL---HLRQELESVSAEKDHLVSE 1779

Human  1667 NIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLK 1731
               :::...|:||||:: |:|:  |.:|    .||||||.|:                     ..
Zfish  1780 ---MSREQKEHLEEMKT-TEEK--LSAV----TVERDQLMES---------------------NT 1813

Human  1732 EHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGI 1796
            ||.:||.:||..:.....|..::..:.:.|:......|....:|:                |:|:
Zfish  1814 EHNQTIVQLRADLQSACAERDSLMVERDQSSSCSALSDGGDLQEI----------------LQGV 1862

Human  1797 VSEKTDKLSNMQKDLENSNAKLQEKIQ---ELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKD 1858
                                  :|.||   |||..:||   ....::.|.|:.::::||      
Zfish  1863 ----------------------RELIQVQGELKQKKHQ---HSDPLSPTHKQKAQLQQL------ 1896

Human  1859 QSLTLSKLEIENL-NLAQKLHENLEEMKSVMKERDNLRRV-EETLKLERDQLKESLQETKARDLE 1921
            ||||   .|:|:| |....|.::||:..:..|....|..| :|.||.::.:..|.::::.||:.:
Zfish  1897 QSLT---TEMESLRNERMVLRKDLEDAAATSKMYQELLHVSKEELKQQQKENTELMEQSSARETQ 1958

Human  1922 IQQELK------TA-RMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQ---ELQ 1976
            :||:|.      || ::|..:|...:.:|:.::           :.|.:.|::|.:|.:   ||.
Zfish  1959 LQQQLNELNEDLTALKVLRDQHDTEIQRLQSEL-----------RSLSREKEDLLEKSRAEGELL 2012

Human  1977 KKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKER 2041
            :::||.|:               :||:|....|.|  ||:..:..||.::|...:|::..:..:.
Zfish  2013 RRDLQTLQ---------------DQLEKSPTEQLL--QSLTEERDQLRRELQGKMEKLTHIETKA 2060

Human  2042 DELRRIKESLKMERDQFIATLREM---IARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKEL 2103
            ::|.:.|..|:.|......:|.|:   ::.|:.|.|   .|.|:..|.:...|.|:...::::::
Zfish  2061 EQLEKQKILLESEVHSLSQSLSEVNCSVSPDQNNTQ---SKHLIMAGIETSEEKLQTAFTKLQQI 2122

Human  2104 LKRYSEMDDHYECLNRLSLDLEKE--------IEFQKELSMRVKANLSLPYLQTKH-IEKLFTAN 2159
            ::|         .:::|| |:.:|        :.|..:....:.|..:....:..| |.|:..|.
Zfish  2123 MER---------PVDQLS-DVNREEWAVLYQLVPFIPKERRTINATHTKKTTRLNHAIIKIAEAY 2177

Human  2160 QRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSR 2224
            ||.:..||             |..:.|....:..|      :..:.::||:.|.      ..||:
Zfish  2178 QRLAHRFH-------------THFQTELQRDVCCF------QESRLQDLLLCIS------PAPSQ 2217

Human  2225 ELRDLK--LNQNMDLHIEEILKDFSE--SEFPSIKTEFQQVLSNRKEM--------TQFLEEWLN 2277
            .|..|:  ..|..:..:..:|:...:  .:...:....::.||...||        |:.|:| |.
Zfish  2218 SLCSLQDDFQQLWEQRLSHLLEKRQQYLQKLECVLVVLEEGLSRYAEMLSEERQHRTEELQE-LK 2281

Human  2278 TRFD-------IEKLKNGIQKENDRICQVNNFF-------NNRIIAIMNESTEFEERSATISKEW 2328
            |...       ||.|:..|.:.:....::|.::       ::.|..:.:.|:|.|.|   :..:.
Zfish  2282 TLLRSAHADAVIELLERQISRRDKAAERLNTYYFVLLNKCDSEINPLKSSSSESERR---LEDQR 2343

Human  2329 EQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEA 2393
            .|.|..||.:|..|.|....|             .|||:  |::.:..|..    |.:|....:.
Zfish  2344 RQTLTLLKAQNGTLPKTEAEL-------------LQDNQ--HLSQQLQQAH----RHVEEIQEQM 2389

Human  2394 KESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIE 2458
            ||..:..::...|..::|:       :|:.::.|....::..::.::..:..|.....|...|:.
Zfish  2390 KELQVQADASNQKQHEDLQ-------ELRVQLMEKQNLVQSLEDKLRHSEALVKSSMTPAASELA 2447

Human  2459 DLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQP 2523
            .||.||||::||.:......|||||...:.:|::.:|||.|:|.||:.||..:.|          
Zfish  2448 ALKDKLVKMELEHIAVTTSHEKEISQMSSMLEHRGDVIRKLKETLRKQQQDDEQS---------- 2502

Human  2524 SNKPLTCGGGSGIVQNTKA-LILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTW 2587
                .|.|....:..:::| ..||      ||::..|:::|.|.    ..|:|..|   .|:..|
Zfish  2503 ----FTDGDEFELKTSSRATTTLK------EKKMEDLQKKNAQF----ESLVSKQQ---EEISKW 2550

Human  2588 KERTLK-REAHKQVTC----ENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDS 2647
            |.|..| :|:.:...|    .::|::|.....|..:.::   ...:|::.|     ||||.|||.
Zfish  2551 KRRAYKMKESKRDAPCTPTKRDAPRTPTKRHPALAETEV---NSPKRSVLD-----SPKSRFFDL 2607

Human  2648 RSK-SLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHA-SSGKDVPECKT 2700
            ||. .|...|..::|||||||..|||....||     |....| ||..|..:|.:
Zfish  2608 RSSVPLSLSHHTQFFDNSSLGTVPEVSCTPAE-----PAATAADSSDSDDEDCSS 2657

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CENPENP_001804.2 KISc 6..336 CDD:214526 230/337 (68%)
KISc_CENP_E 6..329 CDD:276825 226/330 (68%)
SbcC 345..915 CDD:223496 200/739 (27%)
Mplasa_alph_rch 660..1366 CDD:275316 222/815 (27%)
NUDE_C 828..>911 CDD:282704 17/82 (21%)
Mplasa_alph_rch 1151..1951 CDD:275316 191/835 (23%)
Smc 1676..2482 CDD:224117 182/858 (21%)
Kinetochore-binding domain 2126..2476 74/384 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2355..2376 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2508..2533 4/24 (17%)
Globular autoinhibitory domain. /evidence=ECO:0000250 2510..2698 54/195 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2588..2701 39/120 (33%)
cenpeNP_001314688.1 KISc 6..343 CDD:214526 230/336 (68%)
KISc_CENP_E 6..337 CDD:276825 226/330 (68%)
Myosin_tail_1 801..1826 CDD:279860 311/1208 (26%)
CASP_C 984..>1100 CDD:285395 35/115 (30%)
DUF342 <1430..1517 CDD:302792 25/99 (25%)
SMC_prok_B 1468..2193 CDD:274008 206/939 (22%)
GluZincin 1935..>2053 CDD:301352 34/145 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C194323549
Domainoid 1 1.000 456 1.000 Domainoid score I3473
eggNOG 1 0.900 - - E2759_KOG0242
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 899 1.000 Inparanoid score I2841
NCBI 1 1.000 - -
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15270at33208
OrthoFinder 1 1.000 - - FOG0001102
OrthoInspector 1 1.000 - - oto46860
orthoMCL 1 0.900 - - OOG6_101662
Panther 1 1.100 - - LDO PTHR47968
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5166
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 1 1.500 - -
1515.350

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