DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CENPE and cmet

DIOPT Version :9

Sequence 1:NP_001804.2 Gene:CENPE / 1062 HGNCID:1856 Length:2701 Species:Homo sapiens
Sequence 2:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster


Alignment Length:2589 Identity:654/2589 - (25%)
Similarity:1126/2589 - (43%) Gaps:586/2589 - (22%)


- Green bases have known domain annotations that are detailed below.


Human     6 AVAVCVRVRPLNSREESLGETAQVYWKT-DNNVIYQVDG-SKSFNFDRVFHGNETTKNVYEEIAA 68
            ::.||::|||......||       |:. :...|:..|. ::.:.||.||....:.:.|::.:|.
  Fly     8 SIQVCIKVRPCEPGLTSL-------WQVKERRSIHLADSHAEPYVFDYVFDEGASNQEVFDRMAK 65

Human    69 PIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKFPDREFLLRVSYME 133
            .|:.:.:||:||||||||||:|||||||||.|.:.||:..|..:|||:|....:|:|||||.|:|
  Fly    66 HIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETERDFLLRVGYIE 130

Human   134 IYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEM-ALKWITKGEKSRHYGETKMN 197
            ||||.|.|||  .:|.:.|.|.|..|..|.|.  .||.:.|||: .|:.:..|.|.|..|||.||
  Fly   131 IYNEKIYDLL--NKKNQDLKIHESGNGIVNVN--CEECIITSEVDLLRLLCLGNKERTVGETNMN 191

Human   198 QRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSL 262
            :||||||.||::|:||| |.:.|: :.:|..|.||||||||||||.||||.|.|||||.:||:||
  Fly   192 ERSSRSHAIFKIIIESR-KSDHSD-DDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHINKSL 254

Human   263 FILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPVSFDETLTALQFASTAK 327
            ..|..|||.||:.....|.||||||||||||.||||||.|.|||||.|...:|:.:.|.||:.||
  Fly   255 LFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSIMEESQSTLSFATRAK 319

Human   328 YMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQN- 391
            .::..|.|||:.:|..::||..:||..||.:|.|                   ||:    |.:| 
  Fly   320 KIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAE-------------------EER----KNENQ 361

Human   392 EKIENLTRM-------LVTSSSLTLQQELKAKRKRRVTWC-------LGKINKMKNSNYADQF-- 440
            :|:|:|.|.       ::...||:    .|.::|||.|||       |.........:..|||  
  Fly   362 QKVEHLERQIKHDMHKIICGHSLS----DKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPK 422

Human   441 --NIPTNITTKTHKL---------SINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQE 494
              ::|..:...|...         :||:|..:|  :.:||       :::|| |:.||..:    
  Fly   423 VSHLPKPVFFHTSNAGKRWDNIPKTINILGSLD--IGTES-------NSISE-EFLPAECI---- 473

Human   495 NIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNL 559
                :..|.|.|....:|...||      .:|.|..|..|     ...|.||:     |.::...
  Fly   474 ----DFGSPRPDVLKPMLTIRQL------PDLPLTPKGPL-----TTDKIKKE-----IQDLQMF 518

Human   560 KNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMK 624
            .:|.||.||..::::.        |:||..::...::.::.:.|                .::.:
  Fly   519 TSLEKHFEVECEEVQG--------LKEKLAEVTAQRDNLEQESL----------------AEKER 559

Human   625 QTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQL---YQSQLEAKK---KMQ 683
            ....:.|..:|.|..|:|  .|:..||:||:..|..|.:.||.:.|:   .:.:.||.|   |::
  Fly   560 YDALEKEVTSLRADNEAA--NSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLR 622

Human   684 VD------LEKE-----LQSAFNEITK--LTSLIDG----------KVPKDLLCNL--ELEGKIT 723
            ||      ||||     ||.:.:.:|:  |.:..:|          .:..|.:||.  |||..|.
  Fly   623 VDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIA 687

Human   724 DLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKE 788
            ||:.:.|.                      .|.::||.||....::|..:.|..:...||::.|.
  Fly   688 DLESKKNS----------------------CECDQLRLEIVSVRDKLESVESAFNLASSEIIQKA 730

Human   789 SRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQ----NFKTLHMDFEQKYKMVLEENERMNQEIVN 849
            :..:.|.:|:..:::.....|..|.:.||::|    ...|||    :|::.|.|:.:::.:|...
  Fly   731 TDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLH----EKHEHVQEKYQKLQEEYEQ 791

Human   850 LSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLIT 914
            |...|:   |:..|....|.....:.|.....:.|||.|.:.:..:::|.:||::.:..:...:|
  Fly   792 LESRAR---SASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELT 853

Human   915 EKLQQTLEEVKTLTQEKDDL-KQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQE 978
            .|:::.....:.:.:|.|.| .||.||:| |.|.|:.:|......:::...:.........:.::
  Fly   854 AKIKELETNFEEMQREYDCLSNQLMESVQ-ENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQ 917

Human   979 TINTLKS--KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQ 1041
            .||.|..  ::||.|                           |.:|.::...::...:.|::   
  Fly   918 DINLLHQFVQLSESV---------------------------QQIELQHHSGISRLFRANQM--- 952

Human  1042 QRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKN 1106
                 .|.|.:..|:..|||.    |.::.|.:::     :..|.:.|.|...:.:.:|....:.
  Fly   953 -----KLDQSEPGLKLCLESA----EYIEEDNRQS-----DATEPICLKGFLKRHRFQIKRLSQE 1003

Human  1107 HAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKE 1171
            |.  ..||..|..|.::::|::::|||..::..:..:..::|:|:.::..:.|...:.|::::.:
  Fly  1004 HV--DMGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTNLESALLEKSVIINKVEDYQ 1066

Human  1172 LTLEHMETERLELAQKLNENYEEVKS-ITKERKVLKELQKSFETERDHLRG-----YIREIEATG 1230
            ..:|.:|.:..|:...    |||::. :|:|..:.:.|.: ...:.|.|.|     ..||.|...
  Fly  1067 RQIESLEKQNAEMTMV----YEELQDRVTRESSMSESLLR-VPPDEDTLPGCPTSPSRREQEVAT 1126

Human  1231 LQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLP-- 1293
            |:|                :|.||:..||:..|::.|                  |..|..|.  
  Fly  1127 LKT----------------SITELQSQVSDLKAELEN------------------HLRQIQLKDG 1157

Human  1294 NVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEI-KSLTKERDNLKTI 1357
            |:..:....|.|:|..|              .:|:....|:|..::.||.: :...|..|:|..|
  Fly  1158 NIARLQTDFEEMSERCL--------------SMEVRLAELDEDTKQKQELLDRQAQKLSDDLCLI 1208

Human  1358 KEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKP--------KDS 1414
             :.|:.|:.||.|...:....:..:.:|.:|.|...:.|::..|:...:...|.        ||.
  Fly  1209 -DQLQKKNAQLVEQYHKATESLSLADAKPDQILLSSQYDSQIEKLNQLLNAAKDELHDVRRIKDD 1272

Human  1415 ALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEEL 1479
            .:..:.:|.|            ::....||::..:....||...|:.:.|:.|:..|.|:.||.|
  Fly  1273 EISALRMEFL------------LQIETNEKENQAKFYAELQETKDRYESNVAELKEKLLQVEETL 1325

Human  1480 -KVAHCCLKEQEETINELRVNLSEKETEISTI----QKQLEAINDKLQNKIQEI----YEKEEQF 1535
             .|...|..|.|...:..:.|:|:...|.:.:    |.::|.|.:.|:||:.|.    .:.|:.|
  Fly  1326 SSVTVRCQAELEALKSAHKENISQAVEERNNLIVQHQAEMETIRETLKNKLAEASTQQSKMEDAF 1390

Human  1536 NIKQISEVQEKVNE-LKQFKEHRKAKDSALQSIESKMLELTN----------RLQESQEEIQIMI 1589
            . .:|:||:..:.| |.|.||.|....|.|:.::..:.::.|          .|::::.|..:.:
  Fly  1391 R-AEINEVRATLMEQLNQTKEDRDKGASKLEEVKKTLEQMINGGRVMSDTIAELEKTKAEQDLAV 1454

Human  1590 KE--------KEEMKRVQEALQIE---RDQLK-------ENTKEIVAKMK----ESQEK-EYQFL 1631
            .:        :::..:.||.||:|   |||:.       :..:.|||..|    |.:|| :.|.|
  Fly  1455 NKLTKDNIELEKQCSKTQEQLQMESLTRDQISFEIEAHIKKLELIVASSKKRIIELEEKCDQQVL 1519

Human  1632 --------KMTAVNETQ----EKMCEIEHLKE----------QFETQKLNLE-NIETENIRLTQI 1673
                    |::..:|.|    |..|.:|.|:|          :.|.:|.:.| .:||...::|. 
  Fly  1520 ELDKCRLEKLSLESEIQKANSEHSCTMEKLQELQAEMKVLSNRNEKEKCDFETKLETFTFKITD- 1583

Human  1674 LHENLEEMRSVTKERDDLRSVEETLKV---ERDQLKENLRETITRDLEKQEELKIVHMHLKEHQE 1735
            |.|.|:|.:......|||.|..|.||:   |.::|..||::.:                :..|.|
  Fly  1584 LEEVLKEAQHKVILYDDLVSQHERLKICLAEANELSSNLQKKV----------------MSLHTE 1632

Human  1736 TIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK 1800
            .||..:|| |.:..||:.::::|:.:.||.....              .||...:.:|       
  Fly  1633 LIDSQKGI-SSRDVEINELREELKAAMDAKATAS--------------AEQMTLVTQL------- 1675

Human  1801 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSK 1865
                    ||:|...|...||.....||      ||..:||...|::.|::.|..::..:..|. 
  Fly  1676 --------KDVEERMANQAEKFTREAAN------LKGSINELLLKLNSMQETKDMLESGNEELK- 1725

Human  1866 LEIENLNLAQKLHENL-EEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTA 1929
               |.|..:|.|...| ||.|..:..::.|.::|:.......||:::..|...|..|:.:|::..
  Fly  1726 ---EQLRNSQNLRNMLDEESKMCISLKEKLVKLEDAKTSLEQQLRDNKSEIYQRHTELTKEVELG 1787

Human  1930 RMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHK 1994
                          |.:|.|.|.:..::..||:.| |:::..:||.::   ||.:..|: |:..:
  Fly  1788 --------------RNRIGELTKKCEELCSDLENS-DQIRLDLQETKE---QLKKTLEN-NLGWQ 1833

Human  1995 KINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERD-ELRRIKESLKMERDQF 2058
            :  :::::.::.|.....|||..:.|....::|....||:|...|.:: ..:..|||:    |:.
  Fly  1834 Q--KVDEVTRECEKLRFDMQSKEVQNESKVQELISECEELRSTLKSKEASFQSEKESM----DRT 1892

Human  2059 IATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREK-CSRIKELLKRYSEMDDHYECLNRLSL 2122
            |::|.|    |::|                    |.|| ||                  .|.:..
  Fly  1893 ISSLLE----DKRN--------------------LEEKLCS------------------ANDIVA 1915

Human  2123 DLEKEIEFQKELSMRVKANLSLPYLQTKHI--EKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185
            .||.||     .::|.:.:|....:..|.|  |.....|:|.|:...|               ::
  Fly  1916 KLETEI-----AALRPRKSLDRNPVPRKSITFESEIRKNRRISVHDER---------------RQ 1960

Human  2186 EQHESINKFEM--DFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSE 2248
            .....:.:|.:  |.:|......||..|:|..|::..:  ||.:...|...:|.|   .|||   
  Fly  1961 SYWNDVREFGIMTDPVDNNCNCAELNSKLQDCQRELFI--RESQVTALKMELDHH---PLKD--- 2017

Human  2249 SEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMN- 2312
                          .|.:...:.:||....:.:.::||..:|..|.||       |:...|... 
  Fly  2018 --------------ENAQLTKRVIEEQDKAKVEQKRLKMKLQDLNARI-------NDLTTASAKE 2061

Human  2313 -ESTEFEE--RSATIS--KEWEQDLKSLKEK-NEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHV 2371
             ||.:..:  :.||::  .:.|.||:::.|| |.|..:..:.|:.......::....:.|:|.. 
  Fly  2062 PESNQMAQAAKPATVAAQTQTESDLETILEKTNVKYQEAVRMLRYRYHLIQELKEKLRQNENSD- 2125

Human  2372 TSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKV 2425
            ||..|.|:..:...|:......|:..:..:.|....::.|.:.||.:..|:.|:
  Fly  2126 TSNITSLSAGQTSALKAQCESQKKEILAIKYKYEAAKRILAIRNDDLDALREKL 2179

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CENPENP_001804.2 KISc 6..336 CDD:214526 164/332 (49%)
KISc_CENP_E 6..329 CDD:276825 163/325 (50%)
SbcC 345..915 CDD:223496 142/632 (22%)
Mplasa_alph_rch 660..1366 CDD:275316 157/752 (21%)
NUDE_C 828..>911 CDD:282704 17/82 (21%)
Mplasa_alph_rch 1151..1951 CDD:275316 196/886 (22%)
Smc 1676..2482 CDD:224117 166/767 (22%)
Kinetochore-binding domain 2126..2476 64/311 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2355..2376 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2508..2533
Globular autoinhibitory domain. /evidence=ECO:0000250 2510..2698
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2588..2701
cmetNP_524993.3 KISc 8..328 CDD:214526 164/332 (49%)
Motor_domain 8..321 CDD:277568 163/325 (50%)
Smc <680..1449 CDD:224117 189/911 (21%)
TMPIT 779..>867 CDD:285135 17/90 (19%)
Smc 1042..1910 CDD:224117 233/1058 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140817
Domainoid 1 1.000 259 1.000 Domainoid score I1997
eggNOG 1 0.900 - - E2759_KOG0242
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 498 1.000 Inparanoid score I1385
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm40987
orthoMCL 1 0.900 - - OOG6_101662
Panther 1 1.100 - - LDO PTHR47968
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5166
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.790

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