DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CENPE and Klp61F

DIOPT Version :9

Sequence 1:NP_001804.2 Gene:CENPE / 1062 HGNCID:1856 Length:2701 Species:Homo sapiens
Sequence 2:NP_476818.1 Gene:Klp61F / 38135 FlyBaseID:FBgn0004378 Length:1066 Species:Drosophila melanogaster


Alignment Length:1408 Identity:325/1408 - (23%)
Similarity:548/1408 - (38%) Gaps:492/1408 - (34%)


- Green bases have known domain annotations that are detailed below.


Human     7 VAVCVRVRPLNSREESL--GETAQVYWKTDNNVIYQVDG--SKSFNFDRVFHGNETTKNVYEEIA 67
            :.|.||||||||||..:  .|...|....:....:.:|.  :|.|.|||.|.......:||..:.
  Fly    20 IQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCDVYSVVV 84

Human    68 APIIDSAIQGYNGTIFAYGQTASGKTYTMMGSE-----------DHLGVIPRAIHDIFQKIKKFP 121
            :|:|:..:.|||.|:||||||.:|||:||:|:|           ..:|:||||:..:|.:::.. 
  Fly    85 SPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFDELRMM- 148

Human   122 DREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNR-NVYVADLTEEVVYTSEMALKWITKG 185
            :.|:.:|:||:|:|||.:.|||......|..|..:...: :|.:..|.|..|::.:...|.:.||
  Fly   149 EVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVYKLLEKG 213

Human   186 EKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSERAAQTG-AAG 249
            ::.|....|.||.:||||||:|.:::..||.|...  |..:|:..||||||||||..::.| ..|
  Fly   214 KERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEG--EDMLKIGKLNLVDLAGSENVSKAGNEKG 276

Human   250 VRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITP--VS 312
            :|::|..|||:||..||:||..|.|.  ...:.||:|||||:||.||||..||.||.||:|  ..
  Fly   277 IRVRETVNINQSLLTLGRVITALVDR--APHVPYRESKLTRLLQESLGGRTKTSIIATISPGHKD 339

Human   313 FDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQL----------------EE 361
            .:|||:.|::|..||.::|.|.||:..|.:.:||.|.:||..||:.|                .|
  Fly   340 IEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAARDKNGIYLAEETYGE 404

Human   362 VSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML--VTSSSLTLQQELKAKRKRRVTWC 424
            ::|:..:|..|       |.||.||.|...::::|..::.  |:.|.:...||||          
  Fly   405 ITLKLESQNRE-------LNEKMLLLKALKDELQNKEKIFSEVSMSLVEKTQELK---------- 452

Human   425 LGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATK 489
                                    ||.:   |||               ||..||          
  Fly   453 ------------------------KTEE---NLL---------------NTKGTL---------- 465

Human   490 LLNQENIESELNSLRADYDNLVLDYEQLRTEK--EEMELKLKEKNDLDEFEALERKTKKDQEMQL 552
                                       |.|:|  .:.:.:.|||.:|   .|...||::....| 
  Fly   466 ---------------------------LLTKKVLTKTKRRYKEKKEL---VASHMKTEQVLTTQ- 499

Human   553 IHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESI 617
                  .:.::..|::...| .::|...:|..||.:::|::                   |.:..
  Fly   500 ------AQEILAAADLATDD-THQLHGTIERRRELDEKIRR-------------------SCDQF 538

Human   618 EDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKM 682
            :|..|                        :|||:             :...:.|||.|..|    
  Fly   539 KDRMQ------------------------DNLEM-------------IGGSLNLYQDQQAA---- 562

Human   683 QVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLS 747
                                                      |:::|::|: .|.:...:.:.|:
  Fly   563 ------------------------------------------LKEQLSQEM-VNSSYVSQRLALN 584

Human   748 ELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNY 812
            ..||:....|...:.:||:: .||      :||..||:                           
  Fly   585 SSKSIEMLKEMCAQSLQDQT-NLH------NKLIGEVM--------------------------- 615

Human   813 KSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQK--FDSSLGALKTELSYKTQEL 875
            |.:||..|.|....|:..|:.::::.:..:.|.:::..:.:..|  .||......|.:....|.:
  Fly   616 KISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSV 680

Human   876 QEKTREVQERL-----------NEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQ 929
            :|..:::.::|           .|::.|:|:|.|.    :.:.:::..:.|.:...:|::|.|..
  Fly   681 EEHAKQMHKKLEQLGAMSLPDAEELQNLQEELANE----RALAQQEDALLESMMMQMEQIKNLRS 741

Human   930 EKD-----DLKQLQESLQIER----DQLKSDIHDTVNMNID----TQEQLRNALES--------- 972
            :..     .|.:::|| ::.|    |.:||.|.|...:.|:    .|.:|.:.:|:         
  Fly   742 KNSISMSVHLNKMEES-RLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGV 805

Human   973 -----LKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQ-KMVGIDKKQDLEAKNTQTLTA 1031
                 |:.|.:.:|   .|..:|.:      ||.|..:....| :::..:.||.|||        
  Fly   806 ANCSMLQVHMKNLN---QKYEKETN------ENVGSVRVHHNQVEIICQESKQQLEA-------- 853

Human  1032 DVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKK 1096
                             :|||.|:.  ||.::..::||.|            ::..|.:|.....
  Fly   854 -----------------VQEKTEVN--LEQMVDARQQLIT------------EDRQRFIGHATVA 887

Human  1097 QQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIE 1161
            ..  :.||.|....:..|..|                ||||..:|:|:..|:             
  Fly   888 TD--LVQESNRQFSEHAEHQR----------------QQLQICEQELVRFQQ------------- 921

Human  1162 NLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREI 1226
               :|||....|                                    .:..::||.:  |.|.:
  Fly   922 ---SELKTYAPT------------------------------------GTTPSKRDFV--YPRTL 945

Human  1227 EATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHT--KLQEEIPVLHEEQ 1289
            .||               ..|||.:...|        |.::..||:.:.|  :..|     .|..
  Fly   946 VAT---------------SPHQEIVRRYR--------QELDWSDLDTTATIDECSE-----GEHD 982

Human  1290 ELLPNVKEVSETQETMNELEL-----LTEQ---STTKDSTTLA 1324
            ..:.:|:|:|||:..||...:     :|.:   .||::|.:.|
  Fly   983 VSMHSVQELSETETIMNSTPIEPVDGVTVKRGCGTTRNSNSNA 1025

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CENPENP_001804.2 KISc 6..336 CDD:214526 137/347 (39%)
KISc_CENP_E 6..329 CDD:276825 135/340 (40%)
SbcC 345..915 CDD:223496 99/602 (16%)
Mplasa_alph_rch 660..1366 CDD:275316 127/716 (18%)
NUDE_C 828..>911 CDD:282704 14/95 (15%)
Mplasa_alph_rch 1151..1951 CDD:275316 32/184 (17%)
Smc 1676..2482 CDD:224117
Kinetochore-binding domain 2126..2476
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2355..2376
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2508..2533
Globular autoinhibitory domain. /evidence=ECO:0000250 2510..2698
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2588..2701
Klp61FNP_476818.1 KISc_BimC_Eg5 17..365 CDD:276815 139/349 (40%)
Kinesin 25..356 CDD:278646 133/335 (40%)
Microtub_bind 923..>1009 CDD:290642 27/151 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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