DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment STAMBP and CG2224

DIOPT Version :9

Sequence 1:	NP_001340896.1	Gene:	STAMBP / 10617	HGNCID:	16950	Length:	424	Species:	Homo sapiens
Sequence 2:	NP_001263108.1	Gene:	CG2224 / 43617	FlyBaseID:	FBgn0039773	Length:	420	Species:	Drosophila melanogaster

Alignment Length:	439	Identity:	190/439 - (43%)
Similarity:	273/439 - (62%)	Gaps:	49/439 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     5 GDVSLPPEDRVRALSQLGSAVEVNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAFILYNKYITL 69
            |||.  |::|::.||..|:.:||::::|..||:|||.|::|||::|..|||.|:|||||.:|:||
  Fly    11 GDVE--PQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYMTL 73

Human    70 FIEKLPKHRDYKSAVIPEKKDTVKKLKEIAFPKAEELKAELLKRYTKEYTEYNEEKKKEAEELAR 134
            ||||:.:|.||.| |..|.:|..:|:|:...|..|:|:|:||..|.:||.::  ...||||.:
  Fly    74 FIEKIRQHPDYGS-VKAEVRDINRKIKDEIMPTTEKLRAKLLTHYQREYEQF--LASKEAERV-- 133

Human   135 NMAIQQELEKEKQRVAQ-QKQQQLEQEQFHAFEEMIRNQELEKERLKIVQEFGKVDPGLGGPLVP 198
                 :|||:|::|..: |:|::.|:....|...:|      ...|.::     :|.| ..|..|
  Fly   134 -----KELERERERERERQRQKEREKAGSSAIPSLI------PANLHVL-----IDEG-NQPSAP 181

Human   199 DLEKPSLDVFPT----------------LTVSSIQPSDCHTTVRPAKPPVVDRSLKPGALSNSES 247
            ||......|:|.                |..:|...:|..|..:|:    .||:.|| :.:.::|
  Fly   182 DLGLLDQVVYPNDFPTGANRSLPGSGLLLPAASEAAADKTTNSKPS----FDRNQKP-SYNRTDS 241

Human   248 IPTIDGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFTITHVLIPKQSAGSDYCN 312
            : ....||.|.|||.....||:||.|||::.:||||:|.|.|.:|:..|||::.|:|....|.||
  Fly   242 L-LAGSLRLVYVPGDTMEVFLKLALANTSKNIETCGVLAGHLSQNQLYITHIITPQQQGTPDSCN 305

Human   313 TENEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESVAIVCSPKFQETGFF 377
            |.:||::|.:|||..|||||||||||||||||||||||||||||:|:||::||||:||:..||||
  Fly   306 TMHEEQIFDVQDQMQLITLGWIHTHPTQTAFLSSVDLHTHCSYQIMMPEALAIVCAPKYNTTGFF 370

Human   378 KLTDH-GLEEISSCRQKGFHPHSKDPPLFCSCSHVTVVDRA-VTITDLR 424
            .||.| ||:.|:.|||.|||||..|||||....|:.:.::| :.:.|||
  Fly   371 ILTPHYGLDYIAQCRQSGFHPHPNDPPLFMEAQHIRMDNQAKIKVIDLR 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STAMBP	NP_001340896.1	Interaction with CHMP3	1..127		55/121 (45%)
		USP8_dimer	7..114	CDD:312504	50/106 (47%)
		Interaction with STAM	227..231		1/3 (33%)
		MPN_AMSH_like	254..424	CDD:163697	100/171 (58%)
		JAMM motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01182	335..348		12/12 (100%)
CG2224	NP_001263108.1	USP8_dimer	16..119	CDD:286108	49/103 (48%)
CG2224	NP_001263108.1	MPN_AMSH_like	247..419	CDD:163697	100/171 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146886
Domainoid	1	1.000	145	1.000	Domainoid score	I4585
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4719
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2482
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49824
OrthoDB	1	1.010	-	-		D411229at2759
OrthoFinder	1	1.000	-	-		FOG0002716
OrthoInspector	1	1.000	-	-		otm41439
orthoMCL	1	0.900	-	-		OOG6_103166
Panther	1	1.100	-	-	LDO	PTHR12947
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1402
SonicParanoid	1	1.000	-	-		X1584
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800