Protein Alignment STAMBP and eIF3f2

DIOPT Version :10

• Sequence 1: NP_006454.1
• Gene: STAMBP / 10617
• HGNCID: 16950
• Length: 424
• Species: Homo sapiens
• Sequence 2: NP_610210.2
• Gene: eIF3f2 / 35547
• FlyBaseID: FBgn0033069
• Length: 286
• Species: Drosophila melanogaster
• Alignment Length: 229
• Identity: 39/229 - (17%)
• Similarity: 84/229 - (36%)
• Gaps: 61/229 - (26%)

Human    18 LSQLGSAVEVNEDIPPRR----YFRSGVEIIRMASIYSEEGNIEHAFILYNKYITLFIEKLPKHR 78
            ::.....:|:|....|..    :|.:|..:.|.||            ::::.|:....|..|.|.
  Fly    72 MAYASEVLELNMFAYPNERVLGWFCTGKSVSRSAS------------LIHDYYVRECCEGQPLHL 124

Human    79 DYKSAVIPEKKDT-VKKLKEIAFPKAEELKAELLKRYTKEYTEYNEEK------KKEAEELARNM 136
            ...:|:..::..| :....|:..|..  .|..:......|.:..|.:.      :|::
  Fly   125 LVDAALKNQRLSTRLYCAVEMGVPGG--TKGLMFSLVPLEISNENSDLVALRCIEKQS------- 180

Human   137 AIQQELEKEKQRVAQQKQQQLE--QEQFHAFEEMIR--NQELEKERLKIVQEFGKVDPGLGGPL- 196
              ||:..|:.:|...:..|.::  ::..|..:.::|  |..|.:::        |.|..:|..|
  Fly   181 --QQQASKQMERFVPELAQVVDATRDMQHRLDLVLRYINDVLARKK--------KPDNVVGRSLY 235

Human   197 -----VPDLEKPSL---------DVFPTLTVSSI 216
                 ||.|:....         |:...:|:|::
  Fly   236 AALTAVPLLDSDKFRVMFNTNLRDMLMAITLSTM 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STAMBP	NP_006454.1	Interaction with CHMP3. /evidence=ECO:0000269|PubMed:17146056	1..127		19/119 (16%)
		USP8_dimer	13..117	CDD:462647	17/103 (17%)
		Interaction with STAM. /evidence=ECO:0000269|PubMed:10383417	227..231
		MPN_AMSH_like	254..424	CDD:163697
		JAMM motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01182	335..348
eIF3f2	NP_610210.2	MPN_eIF3f	12..280	CDD:163695	39/229 (17%)