| Sequence 1: | NP_006451.1 | Gene: | HEXIM1 / 10614 | HGNCID: | 24953 | Length: | 359 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_731932.1 | Gene: | Hexim / 41778 | FlyBaseID: | FBgn0038251 | Length: | 360 | Species: | Drosophila melanogaster |
| Alignment Length: | 252 | Identity: | 71/252 - (28%) |
|---|---|---|---|
| Similarity: | 108/252 - (42%) | Gaps: | 76/252 - (30%) |
- Green bases have known domain annotations that are detailed below.
|
Human 125 SEASKLGAPAAGG--EEEWGQQQRQLG----------------------KKKHRR------RPSK 159
Human 160 KKRHWKPYYKL--------TWEEKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQE 216
Human 217 EPDLKTGLYSKRAAAKSDDTSDDDFMEEGGEEDGGSDGMGGDGSEFLQRDFSETYERYHTESLQN 281
Human 282 MSKQELIKEYLELEKCLSRMEDENNRLRLESKRLGGDDARVRELELELDRLRAENLQ 338 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| HEXIM1 | NP_006451.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..163 | 20/67 (30%) | |
| Basic region, mediates nuclear localization and interaction with 7SK snRNA and NR3C1. /evidence=ECO:0000269|PubMed:15941832 | 150..177 | 14/40 (35%) | |||
| HEXIM | 164..301 | CDD:464638 | 42/144 (29%) | ||
| Interaction with P-TEFb | 202..205 | 2/2 (100%) | |||
| Autoinhibitory acidic region, in absence of 7SK snRNA interacts with the basic region preventing interaction with P-TEFb and modulating subcellular localization | 210..250 | 8/39 (21%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 213..262 | 8/48 (17%) | |||
| Mediates interaction with CCNT1 | 286..314 | 6/27 (22%) | |||
| Required for inhibition of ESR1-dependent transcription | 310..355 | 8/29 (28%) | |||
| Hexim | NP_731932.1 | HEXIM | 90..181 | CDD:464638 | 37/120 (31%) |