DRSC/TRiP Functional Genomics Resources

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Protein Alignment TRIM3 and ncl-1

DIOPT Version :10

Sequence 1:XP_047282213.1 Gene:TRIM3 / 10612 HGNCID:10064 Length:827 Species:Homo sapiens
Sequence 2:NP_001299853.1 Gene:ncl-1 / 176084 WormBaseID:WBGene00003559 Length:982 Species:Caenorhabditis elegans


Alignment Length:1040 Identity:230/1040 - (22%)
Similarity:368/1040 - (35%) Gaps:338/1040 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    50 PGLQTCRDRWL----QVGGAGCTPGRGWCEWREPSVGAMAKRE------------------DSP- 91
            |.|:.||.|.:    .:||:..:...|..|:....:...|.|.                  ..| 
 Worm     3 PYLEICRKREMSESESLGGSSASTTAGSDEYTMSQIFGAAGRPIPLSTFGTAIPNSWGSAVSQPM 67

Human    92 -------GPEVQPMDKQFLVCSICLDRYQCPKVLPCLHTFCERCLQNYIPAQSLTLSCPVCR-QT 148
                   .|...|:.::.:.|::||:.|:.||||.|.|:||:.||..:: .|...:.||.|. :|
 Worm    68 LAGSFGLAPTPPPVIQEIVKCTLCLEPYRDPKVLACFHSFCKGCLAKHL-EQPERIICPQCHMET 131

Human   149 SILPEQGVSALQNNFFISSLMEAMQQ-----------AP--------DGAH---------DPEDP 185
            .:..:.|:.:|..:|.:.|:|...||           ||        ..||         ||.:|
 Worm   132 QLSVQLGLDSLLTDFGLESVMNKQQQLFANMGLSDIGAPTPSTAIPVPNAHLHPSMVAGSDPSNP 196

Human   186 ----------------------------------------------------------------- 185
                                                                             
 Worm   197 VVGFGFGSPSSTTSSSPPLSNSPTIEQQQHAQLTAMMQGIMSNNNVAVSNGSGVQVASVPAVHCS 261

Human   186 ----------------------------------------------------------------- 185
                                                                             
 Worm   262 GCKSNETKLQATSFCQDCNANLCDNCTMAHKFMHCFADHRVVSLTTPGTGSSSSSTSSSSSASST 326

Human   186 ------------HPLSVVAG---RPLSCPNHEGKTMEFYCEACETAMCGECRAGEHRE--HGTVL 233
                        .|.|::.|   |.:.|..|....:.|:|.:|..|:|.:|...:|..  |...|
 Worm   327 SSHQVPSLGGKQSPDSMMLGSGKRSVLCLQHRASELVFFCVSCNLAICRDCTVSDHPSGTHQYEL 391

Human   234 LRDVVEQHKAALQRQLEAVRGRLPQLSAAIALVGGISQQLQERKAEALAQISAAFEDLEQALQQR 298
            :.||.::....:::.:...|.:...:......|....|.|......|.||:.....:|...:|.:
 Worm   392 IADVADKQMLKMEQLIADARSKHADMLDMFKQVDNKQQVLTASLHNAHAQLEETVSNLINVIQDQ 456

Human   299 KQALVSDLETICGAKQ-------KVLQSQLDTLRQGQEHIGSSCSFAEQALRLGSAPEVLLVRKH 356
            |:.|..|::....|||       |.:||..|.|.|       :..|:.:.:...|..||::.::.
 Worm   457 KKTLAKDIDNAFAAKQIQLTMVDKRIQSMADKLSQ-------TIEFSRRLMSFASPAEVMVFKQL 514

Human   357 MRERLAALAAQAF-PERPHENAQLELVLEVDGLRRSVLNLGALLTTSATAHETVATGEGLRQALV 420
            :..||     |.| ...|..:..|....|::.|..:    |....:::|..:.:.:..|      
 Worm   515 LDTRL-----QLFLGFNPDTSGVLMTPCEIEYLGAA----GLFNNSASTVSQLLGSVHG------ 564

Human   421 GQPASLTVTTKD---KDGRLVRTGSAELRAEITGPDGTRLPVPVVDHKNGTYELVYTARTEGELL 482
            |.|.:......|   ....|...|.|:.|.           :|:..:                  
 Worm   565 GSPINNAPAANDFLMPQAGLAPIGRAQSRI-----------IPIEQN------------------ 600

Human   483 LSVLLYGQPVRGSPFRVRALRPGDLPP---SPDDVKRRVKSPGGP----------GSHVRQKAVR 534
                   |..|..|..:    .|.||.   |..::.|..|..||.          |:.|...|..
 Worm   601 -------QLARSPPHHI----AGSLPMNAYSDSNLLRPNKDFGGSSQSLGPFNPLGASVPGAAAD 654

Human   535 RPSSMY---------STGGKRKDNPIEDE-----------------LVF--RVGSRGREKGEFTN 571
            ..||.|         |.||..:...:::|                 :::  :.|..|..:|:||.
 Worm   655 PFSSQYDKWSLGVEPSVGGLLEGGNVDEEKFQTLFPPSRSQIKRQKMIYHCKFGEFGVMEGQFTE 719

Human   572 LQGVSAASSGRIVVADSNNQCIQVFSNEGQFKFRFGVRGRSPGQLQRPTGVAVD-TNGDIIVADY 635
            ..||:....|.|||||:||..||||..||:|||:||..|:..|||..|..|||: |.||.:|.:.
 Worm   720 PSGVAVNGQGDIVVADTNNHRIQVFDKEGRFKFQFGECGKRDGQLLYPNRVAVNRTTGDFVVTER 784

Human   636 D-NRWVSIFSPEGKFKTKIGAGRLMGPKGVAVDRNGHIIVVDNKSCCVFTFQPNGKLVGRFGGRG 699
            . ...:.:::..|:|..|.||..|..|:||.||..|.||||:.|...|..|...|.::.:|    
 Worm   785 SPTHQIQVYNQYGQFLRKFGANILQHPRGVCVDSKGRIIVVECKVMRVIIFDMFGNILQKF---- 845

Human   700 ATDRHFAGPHFVAVNNKNEIVVTDFHNHSVKVYSADGEFLFKFGSHGEGNGQFNAPTGVAVDSNG 764
            :..|:...|:.|..|:||||:::|...|.:||:|.:|::|.:.|    |.|..|.|.||.::|.|
 Worm   846 SCSRYLEFPNGVCTNDKNEILISDNRAHCIKVFSYEGQYLRQIG----GEGVTNYPIGVGINSLG 906

Human   765 NIIVAD-WGNSRIQVFDSSGSFLSYINTSAEPLYGPQ--GLALTSDGHVVVADAGNHCFKAYRYL 826
            .::||| ..|..:.||...|:.:..:.:..:   ..|  .:||..||.||:|......: .||:|
 Worm   907 EVVVADNHNNFNLTVFSQDGTMIGALESRVK---HAQCFDVALVDDGSVVLASKDYRLY-LYRFL 967

Human   827  826
             Worm   968  967

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRIM3XP_047282213.1 RING-HC_TRIM3 99..146 CDD:438424 17/46 (37%)
Bbox2_TRIM3_C-VII 190..236 CDD:380883 13/50 (26%)
BBC 241..367 CDD:128778 27/132 (20%)
IG_FLMN 405..502 CDD:214720 12/99 (12%)
NHL_TRIM2_like 554..827 CDD:271330 102/297 (34%)
NHL repeat 572..611 CDD:271330 21/38 (55%)
NHL repeat 619..658 CDD:271330 13/40 (33%)
NHL repeat 661..698 CDD:271330 15/36 (42%)
NHL repeat 705..746 CDD:271330 15/40 (38%)
NHL repeat 752..794 CDD:271330 13/42 (31%)
NHL repeat 797..823 CDD:271330 8/27 (30%)
ncl-1NP_001299853.1 RING_Ubox 83..137 CDD:473075 19/54 (35%)
rad18 87..>193 CDD:273165 30/106 (28%)
Bbox1_BRAT-like 259..305 CDD:380871 0/45 (0%)
Bbox2_BRAT-like 349..392 CDD:380856 11/42 (26%)
CC_brat-like 399..520 CDD:467844 27/132 (20%)
NHL_brat_like 697..967 CDD:271329 100/281 (36%)
NHL repeat 720..756 CDD:271329 20/35 (57%)
NHL repeat 767..808 CDD:271329 13/40 (33%)
NHL repeat 811..847 CDD:271329 15/39 (38%)
NHL repeat 851..891 CDD:271329 15/43 (35%)
NHL repeat 896..934 CDD:271329 12/37 (32%)
NHL repeat 939..964 CDD:271329 8/25 (32%)

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