Protein Alignment PDLIM5 and Pax

DIOPT Version :9

• Sequence 1: NP_001243355.2
• Gene: PDLIM5 / 10611
• HGNCID: 17468
• Length: 625
• Species: Homo sapiens
• Sequence 2: NP_001033913.1
• Gene: Pax / 35215
• FlyBaseID: FBgn0041789
• Length: 581
• Species: Drosophila melanogaster
• Alignment Length: 586
• Identity: 146/586 - (24%)
• Similarity: 218/586 - (37%)
• Gaps: 164/586 - (27%)

Human   128 GKIPP--KRPPR----KHIVERYTEFYHVPTHSDASKKRLIEDTEDW--------RPRTGTTQSR 178
            |||.|  ::|.|    |.|:..|.               |:.|.::.        :|:.||.|.:
  Fly     7 GKIDPGARQPYRTARSKGILPGYA---------------LLADLQNSVPGQPQQPQPQYGTVQPK 56

Human   179 SFRILAQITGTEHLKESE-ADNTKKAKFDSALEDLPKSGP-HPPATPQVLTIGSQVATLSKVATT 241
            .          :.|::.: .|||            |..|. ...|.|||......|.|.|..|..
  Fly    57 H----------QALQQQQFVDNT------------PGYGSLRGKAQPQVYQEHYSVETRSPTAGH 99

Human   242 YSSLSSSTGNVEDSFEGFRNFSTFSSPARYSAAVLSSAAATVSAVIATKTRLYTPERYHSLLDAL 306
            ..:.||:|       .|:.|..  |.|.:  ||..|:..:.:.:::....::..|..|.
  Fly   100 DFNGSSTT-------PGYANQG--SLPRQ--AAGASTGLSELDSLLQDLQKIDVPVNYS------ 147

Human   307 CISPVSKPLAF-SY--------LQSSRKSTGSIHVKKTSNS---QEPSPQLASSVASTRSMPESL 359
              :||||.... ||        :.|..|...:.|:....|.   :.|:|....::....:..|.|
  Fly   148 --TPVSKYNTMNSYATVEERPSVDSLLKELDNAHIYAVPNGSAHKSPTPGRHVTITVRETKTEKL 210

Human   360 DSPTSGRPGVTSLTAAAAFKPVGST--GVIKSPSWQRPNQGVP---------------------- 400
            ..|..               |||:.  .:::......||..||
  Fly   211 TGPDG---------------PVGTVEEQIVQQKDSYTPNHAVPGQQVHQAYTSQATKELDDLMAS 260

Human   401 -STGRISNSAT----------YSGSV--------APANSALGQ---TQPSDQDTLVQ--RAEHIP 441
             |..::||...          :|.:|        |..|....|   ||..::.|:|:  |.:.:.
  Fly   261 LSDFKVSNGTNGIGNGSHPQQHSSTVQHQTVTDYARPNKGSQQAHLTQTIEETTIVEDSREDQLD 325

Human   442 A------------GKRTPM---CAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEK 491
            :            |..|..   |..|.:.|.|..:.||||:||||.|.|.||...:....|.|..
  Fly   326 SMLGNLQANMSRQGVNTVQKGCCNACEKPIVGQVITALGKTWHPEHFTCNHCSQELGTRNFFERD 390

Human   492 GALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCE 556
            |..|||..|...|:|.|..|...||.:.::||.:|||...|.|..||:......||..||:|||.
  Fly   391 GFPYCEPDYHNLFSPRCAYCNGAILDKCVTALDKTWHTEHFFCAQCGQQFGEEGFHERDGKPYCR 455

Human   557 TDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAH 621
            .||:.:|...|:||...|.  :.::.||...||..||||..|.:..:|.:||..:..|.|:.|.|
  Fly   456 NDYFEMFAPKCNGCNRAIM--ENYISALNSQWHPDCFVCRDCRQPFQGGSFFDHEGLPYCETHYH 518

Human   622 S 622
            :
  Fly   519 A 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDLIM5	NP_001243355.2	PDZ_signaling	10..82	CDD:238492
		DUF4749	105..201	CDD:406377	18/87 (21%)
		LIM1_ENH	449..500	CDD:188837	22/50 (44%)
		LIM	508..559	CDD:413332	20/50 (40%)
		LIM3_ENH	567..621	CDD:188843	19/53 (36%)
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	22/51 (43%)
		LIM2_Paxillin_like	407..458	CDD:188723	20/50 (40%)
		LIM3_Paxillin_like	466..518	CDD:188724	19/53 (36%)
		LIM4_Paxillin	525..576	CDD:188795

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810