DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDLIM5 and alp-1

DIOPT Version :9

Sequence 1:	NP_001243355.2	Gene:	PDLIM5 / 10611	HGNCID:	17468	Length:	625	Species:	Homo sapiens
Sequence 2:	NP_001023371.1	Gene:	alp-1 / 177701	WormBaseID:	WBGene00001132	Length:	1424	Species:	Caenorhabditis elegans

Alignment Length:	505	Identity:	142/505 - (28%)
Similarity:	213/505 - (42%)	Gaps:	128/505 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   155 DASKKRLIEDTEDWRPRTGTTQSRSFRIL-AQITGTEHLK---------ESEADNTKKAKFDSA- 208
            |..:.|.||.....:.....||::...:| :.|...::|:         :::|.:.:..||:..
Worm  1009 DDDRVRAIECIARHQSELEQTQTQLSTLLESAIVYLQNLRPELELTEPIDNDAKSLETVKFEPTR 1073

Human   209 ---------------LEDLPKSG------PHPPATPQVLTIGS--QVATLSKVATTYSSLSSSTG 250
                           ||.||..|      |.||...:|....|  .:|....|....|.::.|..
Worm  1074 AEQRVNEIRKKVLEDLEHLPILGDGMDSVPPPPPERKVFPFQSYQPIAPQFPVPAAESPVTQSLH 1138

Human   251 NVEDSFEGFRNFSTFSSPARYSAAVLSSAAATVSAVIATKTRLYTPERYHSLLDALCISPVSKPL 315
            :|.|.|...|.    .:|        :...|..|...|..:|.:...|...::
Worm  1139 DVLDEFYSLRK----PTP--------TQNVAQSSDTTAEDSRNFLASRLGQVM------------ 1179

Human   316 AFSYLQSSRKSTGSIHVKKTSNSQEPSPQLASSVAST---RSMPESLDSPTSGRPGVTSLTAAAA 377
                :..::|:.||      :.|.:...|..||...|   |:..|:.....:|.|      .|..
Worm  1180 ----IDENKKAGGS------NGSSQHHNQQGSSYTKTSFERTTTETRPQQNTGAP------RAGD 1228

Human   378 FKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPA 442
            |:                     .||.::.:.|              ||.:
Worm  1229 FR---------------------GTGHLTTTTT--------------TQQN-------------- 1244

Human   443 GKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAH--CKNTMAYIGFVEEKGALYCELCYEKFFA 505
            |.|.|.|..|.|.|||.|::|.||||.||.|.||:  |:..:...|||||.|..:||.|:|:..|
Worm  1245 GGRAPFCESCKQQIRGAFVLATGKSWCPEHFVCANSSCRRRLLECGFVEEDGQKFCESCFEQHIA 1309

Human   506 PECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGC 570
            |.|.:|.:.|:.:.::||::.||.:||.|..|.||..|:.|:||.|.||||.|:.|||.|.|..|
Worm  1310 PRCNKCSKPIISDCLNALQKKWHPTCFTCAHCQKPFGNSAFYLEQGLPYCEQDWNALFTTKCVSC 1374

Human   571 EFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHA 620
            .:||||||.::||||..:|..||.|:.|..:|||::||:|..:|.|:.||
Worm  1375 RYPIEAGDRWVEALGNAFHSNCFTCARCNHNLEGESFFAKNGQPFCRLHA 1424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDLIM5	NP_001243355.2	PDZ_signaling	10..82	CDD:238492
		DUF4749	105..201	CDD:406377	10/55 (18%)
		LIM1_ENH	449..500	CDD:188837	26/52 (50%)
		LIM	508..559	CDD:413332	22/50 (44%)
		LIM3_ENH	567..621	CDD:188843	27/54 (50%)
alp-1	NP_001023371.1	PDZ_signaling	5..80	CDD:238492
		DUF4749	137..>197	CDD:292558
		ZM	137..162	CDD:128974
		LIM_ALP_like	220..271	CDD:188746
		LIM1_Enigma_like_1	1251..1304	CDD:188839	26/52 (50%)
		LIM	1312..1363	CDD:295319	22/50 (44%)
		LIM3_Enigma_like_1	1371..1424	CDD:188845	25/52 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161457065
Domainoid	1	1.000	76	1.000	Domainoid score	I6302
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	250	1.000	Inparanoid score	I2288
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	1	1.000	-	-		otm15160
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24214
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.990