DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAICS and Paics

DIOPT Version :9

Sequence 1:	NP_001378939.1	Gene:	PAICS / 10606	HGNCID:	8587	Length:	814	Species:	Homo sapiens
Sequence 2:	NP_572826.1	Gene:	Paics / 32228	FlyBaseID:	FBgn0020513	Length:	429	Species:	Drosophila melanogaster

Alignment Length:	427	Identity:	247/427 - (57%)
Similarity:	310/427 - (72%)	Gaps:	9/427 - (2%)

- Green bases have known domain annotations that are detailed below.

Human   384 ATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQ 448
            |:.|...:||.:.|||||:||:|.:.||..||.|||:||||:..:.:.|.|||.|||.....:|:
  Fly     7 ASIEGYKLGKVIIEGKTKQVYDLPEQPGLCLLLSKDRITAGDGVKAHDLAGKAEISNTTNGQVFR 71

Human   449 LLQEAVTSYKSNRIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPP 513
            ||.||       .|:||:.::||..||||.:|:|||||||.||:|||||||||.||.|||:|.||
  Fly    72 LLNEA-------GIRTAYVKQCGAKAFIARKCQMIPIEWVTRRLATGSFLKRNVGVPEGYRFSPP 129

Human   514 KVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVD 578
            |.|.|||||||:||||||||:::|||...||:|||.|||||...|..:|||||::|..:||.|:|
  Fly   130 KQETFFKDDANHDPQWSEEQIVSAKFELNGLVIGQDEVDIMRRTTLLVFEILERAWQTKNCALID 194

Human   579 MKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAE 643
            ||:|||: .....|||||:||:|||||||:||:....|||.||:|..||...|..||:||.||||
  Fly   195 MKVEFGI-CDDGNIVLADIIDSDSWRLWPAGDKRLMVDKQVYRNLASVTASDLDTVKRNFIWVAE 258

Human   644 RVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGD 708
            ::..::..:... ||:||||.||:.|.|||..:|.:.|:..||||:||||||:|||||..|||..
  Fly   259 QLADIVPKKDHL-VVILMGSASDISHSEKIATSCRSLGLNVELRVSSAHKGPEETLRIVREYESV 322

Human   709 GIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQDVWSSLRLPSGLGCSTVLSPEGSA 773
            ....:||||||||||||||:||:|.||||:|||:..|....||||||.|||||||:|||.||.:|
  Fly   323 MSNLIFVAVAGRSNGLGPVVSGSTNYPVINCPPVKSDNMQVDVWSSLNLPSGLGCATVLYPEAAA 387

Human   774 QFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKIR 810
            ..||.|.||.|.:||||||...||.:|:||:|||::|
  Fly   388 LHAATILGLGNFMVWSKLRVKALNNFITLKKADKELR 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAICS	NP_001378939.1	Myb_DNA-bind_4	6..91	CDD:404682
		Myb_DNA-bind_4	151..235	CDD:404682
		SAICAR_synt_Ade5	389..647	CDD:133471	148/257 (58%)
		purE	657..810	CDD:273474	96/152 (63%)
Paics	NP_572826.1	SAICAR_synt_Ade5	12..260	CDD:133471	148/255 (58%)
Paics	NP_572826.1	purE	271..424	CDD:273474	96/152 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149271
Domainoid	1	1.000	285	1.000	Domainoid score	I1626
eggNOG	1	0.900	-	-		E1_COG0152
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4710
Inparanoid	1	1.050	496	1.000	Inparanoid score	I1399
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48634
OrthoDB	1	1.010	-	-		D307109at33208
OrthoFinder	1	1.000	-	-		FOG0004768
OrthoInspector	1	1.000	-	-		oto90523
orthoMCL	1	0.900	-	-		OOG6_101413
Panther	1	1.100	-	-	LDO	PTHR43599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1036
SonicParanoid	1	1.000	-	-		X3921
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800