DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Topors and Topors

DIOPT Version :9

Sequence 1:	NP_598858.2	Gene:	Topors / 106021	MGIID:	2146189	Length:	1033	Species:	Mus musculus
Sequence 2:	NP_001261083.1	Gene:	Topors / 37188	FlyBaseID:	FBgn0267351	Length:	1038	Species:	Drosophila melanogaster

Alignment Length:	1112	Identity:	259/1112 - (23%)
Similarity:	406/1112 - (36%)	Gaps:	301/1112 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse    15 EEGEAPPLVPAEEGRRRSRRVRLRGSCRHRPSLLSRRELASNGPAVPATASSE---------IMA 70
            |.|.:..:.|..||.....|.....:.:......|..|...|....|.:|..:         ..|
  Fly    20 ELGASVIVEPGLEGSNAGGRTLPAAAIKFADLTESGSESGDNEAEEPVSAGPDNANAIGEPGTSA 84

Mouse    71 SAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKN 135
            |||:|               ..||..: ||...|.|||.|.....:.|.|:|:|||:|:.||||.
  Fly    85 SAAEE---------------NGTVERN-SPPPNCAICLSRCRRKCFTDSCMHQFCFKCLCEWSKI 133

Mouse   136 KAECPLCKQPFDSIFHSVRAEDDFKEYVLR-----PSYNGSFTNPEVRRFRYRTTMTRERSASLY 195
            |.|||||||||.:|.|:||..||:..|.::     |:.|.|.....|||.|| |.:.:.::..:.
  Fly   134 KPECPLCKQPFRTIIHNVRTLDDYDRYPVQTTSPVPTENPSLRYHIVRRPRY-TPLVQNQAVIVN 197

Mouse   196 SPSSTVSRRTTTPPDSGVLFEGLGISTRPRDVDIPQFMRQMALRGPTTTDERSLRKIQ--EQDII 258
            ...:.::        :|...|           |:.......|.|       ||..:.:  ..:::
  Fly   198 DIEAAIA--------AGAAGE-----------DVLSAAEVAAGR-------RSYSRFEPYRSELM 236

Mouse   259 NF-----------------RRTLYRAGVRVRSIEDG--GRYRDISAEFFRRNPACLHRLVPWLKR 304
            |:                 ||.:|...:....:.|.  |.:|:.||.|:|.|||.:|||:||:.|
  Fly   237 NYYQHDQDASTSGSLSQLWRRYVYDRKLYALPVSDSVTGHFREWSARFYRNNPAQIHRLMPWIHR 301

Mouse   305 ELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAA 369
            ::..|.......||.|..::...:....|....|...|.|:|..||.|||||..:|||||:::..
  Fly   302 DIMCLLRNAAHSVNTVMTLMSDLLPMTSLLGPTFRRRLSPYLGERTSHFIHELFNFARSPYDING 366

Mouse   370 FDQHANYDCPPSSE---------------------EGSRSDSSVIT--ISPD------EAETQEL 405
            :|....|....:.|                     |...||:..|.  .|||      ...|..:
  Fly   367 YDHVVQYSARVAEEVEVDLLDMVETQSSNGDDLNLEVGDSDADAINAGFSPDWSPPRVRPSTSVI 431

Mouse   406 DMN-----ASTVRQAPWDDETPGPSYS-----SSEQVHVGVSSLLNSSDSSDE----ELVSGGTT 456
            ..|     :.:|..|....|.||.|..     .|:.|.:.:|....::.:|:|    |:..|...
  Fly   432 VTNPGATHSFSVTMASDGSELPGISIRRTTNVGSQTVAINLSMRRPAAVASEEPEVIEIDDGDAA 496

Mouse   457 SQIQGVQTNDDVNN-----------------DSDSSS---DNCVIVGFVKPLAERTPELVELSSD 501
            :..:....||..|.                 :|.|||   |.||.|..:||...||||.|.|.|:
  Fly   497 ANAEVAAINDGSNTSRRHAGATLPVTAHIELESSSSSGDEDECVFVLELKPPHMRTPEQVSLDSN 561

Mouse   502 SEELGPYEKVETVKTQEQEQSYSSGDSDVSRASSPRSVLGKDEQMSKSHCDS------------- 553
            |:.       :.|...||.::.....::.....||..:..:|:.:......|
  Fly   562 SDS-------DVVFVNEQHEAAPDAIAENRSTQSPLDLASRDQGLFMGPSTSGAAANRGKNWKLV 619

Mouse   554 --DTR----------ISSKKEEKRSTSLPAPRDSSSTRGDRVCSPYNHRHRKGGRSRSSDSRSQS 606
              .||          |.|||  .|.:|:||..||.|:......|.::.       |.|||..|..
  Fly   620 MAQTRRLDQLRTLRSIRSKK--SRRSSMPARSDSGSSPSSCSSSSFHF-------SSSSDEDSSD 675

Mouse   607 RSGHDPRNHRKHGKKRLRNKRSRSRES----SSRPRARKD-------------KKRSRTRDSSWS 654
            .|..:....:|..:||:.|.:...:||    :||.|..||             ||..|..:||..
  Fly   676 SSTTNSEPPKKKSRKRVANNKRSKKESIGKRTSRKRKAKDQNMEMLEQQQISQKKPQRQPESSSD 740

Mouse   655 RRSQTLSLSSGSTSRSRSRSSDHGKRRSRSRNRDRYY------LRNNYGSKYKWEYTYYSRN--- 710
            ..|.:...|.|.:|.|..:.:.:..:.|...:.|...      ||    :..|.|.|...|.
  Fly   741 SPSSSDDESGGDSSESSGQPNTNNNKSSSDSDDDSAVNMQLSALR----ATLKAEATLEDRKPVK 801

Mouse   711 -----KDRDGYESSYRRRTLSRAHYSRQSSSPEFRIQSFSERTNARKKNHSERKYYYYERRRSRS 770
                 .|.|.....:.|.|.|    .|:.:.|     ..|.....|..:||.      :..:|.|
  Fly   802 LELQLPDDDQAGPLHSRMTPS----PREDNEP-----GCSAPKRRRSCSHSN------QSSQSAS 851

Mouse   771 VSSNRSRTTSAGP-------------DRVRNEKPGGKRKYKTRHLEGTSEEAQPA-----REFTS 817
            ::|:.:.|:|:.|             |.:....|..:.......|...|...||.     .|..:
  Fly   852 LASSSTATSSSAPLSSFAWGAAGFSGDPLMRGHPAMEEHDIANSLIELSTLTQPVNIGLFNEHYN 916

Mouse   818 KGKDSHYQKSKL-----------DGSYKNESDSFSDSRSSDRETKHKRRRRRTRSL--SVEIVYE 869
            ..::|....|..           |.:.:|..|:.:|..:|        |.|...||  ::::|.|
  Fly   917 SAENSMGMLSNTLCDSPQTLAADDANLENYFDTDADPEAS--------RERDAYSLEAAIDVVGE 973

Mouse   870 GK---ATDTS-----------------KHHKKKKKKHKKKHKKHHGDNTSRSPVVITIDSDSDGE 914
            .:   |.||:                 :..::::|..:::.::...|:          |||:..|
  Fly   974 SELQIAEDTATATEEQDEEDEEDEDQEEDDQEEEKAAEEEEEEEEDDD----------DSDNHDE 1028

Mouse   915 SEVKAGI 921
            ::...|:
  Fly  1029 NDENQGL 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Topors	NP_598858.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		6/20 (30%)
		Required for DNA-binding. /evidence=ECO:0000250	52..376		104/358 (29%)
		RING	103..146	CDD:238093	24/42 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..477		19/91 (21%)
		Interaction with SUMO1. /evidence=ECO:0000250	438..654		68/281 (24%)
		Sumoylation and localization to discrete nuclear foci. /evidence=ECO:0000250	438..574		42/184 (23%)
		Interaction with TOP1. /evidence=ECO:0000250	457..879		117/548 (21%)
		Interaction with p53/TP53. /evidence=ECO:0000250	457..731		82/349 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..692		54/243 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	713..934		46/260 (18%)
		Interaction with UBE2I. /evidence=ECO:0000250	851..914		14/84 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	970..1033
Topors	NP_001261083.1	RING	102..144	CDD:238093	19/41 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835931
Domainoid	1	1.000	125	1.000	Domainoid score	I5486
eggNOG	1	0.900	-	-		E1_KOG4430
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3957
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003652
OrthoInspector	1	1.000	-	-		otm42808
orthoMCL	1	0.900	-	-		OOG6_104232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9253
SonicParanoid	1	1.000	-	-		X4653
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.680