Protein Alignment SLCO1B1 and Oatp74D

DIOPT Version :9

• Sequence 1: NP_006437.3
• Gene: SLCO1B1 / 10599
• HGNCID: 10959
• Length: 691
• Species: Homo sapiens
• Sequence 2: NP_001163460.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Alignment Length: 715
• Identity: 183/715 - (25%)
• Similarity: 326/715 - (45%)
• Gaps: 74/715 - (10%)

Human     2 DQNQHLNKTAEAQPSEN--------KKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERR 58
            |.:..||..:.|:.|.:        :..|......:|:....|::|.:.:......|.|..||:.
  Fly   140 DFDSDLNGGSSAESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFVSVITTIEKL 204

Human    59 FEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMG-YYR 122
            |:|.|...|.:..:.|:|.:...:.::||..:.|||:.|..|..:..|.....|||||..| ...
  Fly   205 FQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLM 269

Human   123 YS----KETNINSSENSTST----LSTCLINQILSLNRASPEIVGKGCLKE------SGSYMWIY 173
            :|    ::|.::...||.|:    .|:..:|..|.:...:....|..|.:|      |.|.:.:.
  Fly   270 HSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQASHSKITVI 334

Human   174 V---FMGNML-RGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMY 234
            |   |.|::| .|||:|.:..||:.||||......|.:|:.:...:.::||..||..||..::.
  Fly   335 VLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRW- 398

Human   235 VDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKE--RKASLSLH 297
                ||:.|......||.||:|||||..:..|...:::||..|..|:.....||.  :.|:.:..
  Fly   399 ----YVNFSNPGFDATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQTATPAAP 459

Human   298 VLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKY 362
            |     |.::...|.:..|.:.:.::.....|::     ...:|.||.:      .|.:|::.||
  Fly   460 V-----EPEEKPKLKDFPKTVRRQLSNDILMFRT-----ASCVFHLLPI------AGLYTFLPKY 508

Human   363 VEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFF 427
            :|.|:...:..||::.....|.:...|:.:.|..|.|.|....|:|.:..|||::..:..::..|
  Fly   509 LETQFRLATYDANMIAAFCGILVMGIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMF 573

Human   428 ILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSS 492
            |.|.....||...: |||:|....   |......:|.||:..:.|:|. :|..|||.|.|||.||
  Fly   574 IGCSMNDFAGYKPS-DGNSPALIE---PTCSAALNCTCDKENFAPICA-DGKMYISACHAGCSSS 633

Human   493 S--GNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSH 555
            |  .:....::.:|:|:....      .|..|.|  |:.| :.|.:|:.|..:.:|..:......
  Fly   634 SLRPSDNRTLYSDCACIPDAP------EAVNGYC--DNNC-KNFIYFILIFAICVFMHSTSEVGS 689

Human   556 VMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTS 620
            ::|:::...|:.|::|:|.....|...|.:..||.:||::|:.|:.|. :.||..|:|..|::.:
  Fly   690 MLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWK-SVCGKHGACSLYDADT 753

Human   621 FSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDI---NASENGSVMDEANLESLNKNKHFVPS 682
            |.:.:||:::.:    :.|..::...:.:|....||   :..|.|...:...||.....:...|:
  Fly   754 FRQYFLGITAGI----MFLAFLMDLVVWRKAHRIDIAPEDPQEGGPASNGRTLEVSESKQPITPA 814

Human   683  682
              Fly   815  814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO1B1	NP_006437.3	OATP	29..621	CDD:281175	165/614 (27%)
		MFS	31..>427	CDD:119392	108/416 (26%)
		KAZAL_SLC21	455..508	CDD:238650	19/54 (35%)
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	165/614 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820