DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLCO1B1 and Oatp58Dc

DIOPT Version :9

Sequence 1:	NP_006437.3	Gene:	SLCO1B1 / 10599	HGNCID:	10959	Length:	691	Species:	Homo sapiens
Sequence 2:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	759	Identity:	200/759 - (26%)
Similarity:	317/759 - (41%)	Gaps:	138/759 - (18%)

- Green bases have known domain annotations that are detailed below.

Human     7 LNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKT--------LGAII------MKSSIIHIER 57
            :||.....|.|...|  | |..:|.......|..:|        :|.|.      ...:|..||:
  Fly    79 INKLLAESPLEKNVT--C-GFWIFKGTFYQRFANQTAYVLLYGIVGCIFSMTYAYFNGTITTIEK 140

Human    58 RFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMG--- 119
            ||:|.|...|.|....:|...||...::|:..|.|||:.||.|...:....:||..|||..|
  Fly   141 RFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGPGE 205

Human   120 -YYRYSKETNINSSENST-STLSTCLINQILSLNRASPEI-VGKGCLKESGSYMWIYVFMGNMLR 181
             ....:.|......||:| ..:.......:..||....|. ||:|.....     :.:|:...:.
  Fly   206 DALALTSEFGGMPDENATMEAIEEQRSKTLCRLNGGGAECEVGEGNFAPQ-----LLLFVAQFIS 265

Human   182 GIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIR 246
            |||.:....||:||:||..|:..:...|.:...:.|:||.||:.|.|...::|:   ...:..:
  Fly   266 GIGGSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRMLGPAIGYALASFCLRLYI---APQMHPV- 326

Human   247 ITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNK----------PQKERKASLSLHVLET 301
            |...|.||:|||||.:||.|.....|.:   ||...|.:          .:..|:....|.|..|
  Fly   327 INNKDPRWLGAWWLGWLVMGGLLSFSGV---FLSMFPKELPRAVARRKVEENRRREKERLSVKST 388

Human   302 NDEKDQTANLTNQGKNITKNVTGFFQ----SFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKY 362
            ..|: .||.|   .:..|......||    :|:.::||..|:...|.::..:..|...:.:..||
  Fly   389 EKER-LTAEL---DQKTTAEAKASFQDMLKTFRRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKY 449

Human   363 VEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFF 427
            :|.||.|.::.::::.|.:.:...|.|:.|.|:||.::|.....:|.::.....::::..|.|.|
  Fly   450 IEVQYRQSAATSSMVTGTVALAFSAVGVLLSGFIISRYKPRARYMAAWNVIVGFLTVAGILAYAF 514

Human   428 ILC-----------ENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITY 481
            |.|           .:.|:||.|.|                 |||.|:||..::.||||.|.:||
  Fly   515 IGCPGNESSVIVNIHDSSLAGNTTT-----------------CNSACSCDYVRYSPVCGENNMTY 562

Human   482 ISPCLAGCK----SSSGNKKPIVFYNCSCLEVTGLQN-------------------RNYSAHL-- 521
            ||.|.||||    :|.|.|   :||:|||:......|                   :|.|.|.
  Fly   563 ISACHAGCKKLLVNSEGKK---IFYDCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQL 624

Human   522 ----------GECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHS 576
                      |.||.:  |..:|..|:|:.....|..|.|..|:.::.|:.|..:.|:.|:||..
  Fly   625 EALANGQAMPGACPVN--CWTQFVAFLAVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGM 687

Human   577 MVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSF-------SRVYLGLSSMLRV 634
            .:...|..|.:||:||.:.|..|:.|. ..|..:|:|..|:..|.       :.|::.:.::..:
  Fly   688 TLCSMLAFIPSPIFFGWVFDRVCLVWG-KTCTNKGNCWLYDPLSMRYTLNFTAAVFIAIGAIFDL 751

Human   635 SSLVLYIILIYAMKKKYQEKDINASENGSVMDEANLESLNKNKH 678
            .      :..||...|..::|:...|...|..|   |..|..|:
  Fly   752 G------VWYYAKDLKIFDEDVKEVEMKIVQHE---EEANNEKN 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLCO1B1	NP_006437.3	OATP	29..621	CDD:281175	181/671 (27%)
		MFS	31..>427	CDD:119392	110/429 (26%)
		KAZAL_SLC21	455..508	CDD:238650	28/56 (50%)
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	178/657 (27%)
		MFS	114..>518	CDD:119392	110/419 (26%)
		KAZAL_SLC21	537..590	CDD:238650	30/72 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820