Protein Alignment SLCO1B1 and Oatp58Db

DIOPT Version :10

• Sequence 1: NP_006437.3
• Gene: SLCO1B1 / 10599
• HGNCID: 10959
• Length: 691
• Species: Homo sapiens
• Sequence 2: NP_611658.3
• Gene: Oatp58Db / 37544
• FlyBaseID: FBgn0034715
• Length: 680
• Species: Drosophila melanogaster
• Alignment Length: 674
• Identity: 177/674 - (26%)
• Similarity: 322/674 - (47%)
• Gaps: 71/674 - (10%)

Human    29 MFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHR 93
            ||:....::.....:.......:|..:|:||.|.:.:.|.|....:|..:....|:||:.|:.||
  Fly    53 MFVIVYGIASCFLAMAFTYFTGTITTMEKRFNIPTKISGLITVGNDISTVFSSAFLSYYASRGHR 117

Human    94 PKLIGIGCFIMGIGGVLTALPHFFMG----YYRYSKETNINSSENSTSTLSTCLINQILSLNRAS 154
            |:.:.:|..|:.|..:|...||.|.|    ..|.::|..:  ||:..::|:....|..|...:.|
  Fly   118 PRWVALGLIIIAIFCLLMLTPHIFYGPGEEALRLTEEYGM--SESFGASLNITEKNDSLCHEKNS 180

Human   155 PEIVGKGCLKESGSYMWIYV-FMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMI 218
                  .||:.:|.|..|.: |:...:.|||.:.....||||:||.:....:...|...:.:.|:
  Fly   181 ------NCLERAGDYTPIVLFFIAQFIGGIGCSLFYAPGLSYMDDNSASSKTPAMLSWSSFLRML 239

Human   219 GPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTP 283
            ||.:||::.||..::|:|    ......||..|.||:||||:.::   |.:.|.:|...|:...|
  Fly   240 GPAMGFSMVSLCLRLYID----PFKKPLITTNDPRWMGAWWIGWI---LLTFILTISAVFVGMFP 297

Human   284 NK-PQ-KERKASLSLHVLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTL 346
            .: |: |.|:       |:.:.|:|    :...|::.    .....|.|.:.:|.:||..:|.::
  Fly   298 KEMPRAKARR-------LKADGEED----IPLAGRSF----QDMLDSLKRLASNKVYVYNMLASI 347

Human   347 LQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFS 411
            |.:..|:..:.:..||:|.||.|.:|.:.:..|...:...|:|:.:.||:|.|:|.:...:|.::
  Fly   348 LYLFGYMPYWIFTPKYIEIQYRQSASTSTMATGTWALGFSAAGILISGYVISKYKPSARAMAAWN 412

Human   412 CFTAVMSLSFYLLYFFILCENKSVA-GLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCG 475
            .....::::..|.|..:.|:....| .|::...|::            |::.|.|:...:.|||.
  Fly   413 FVVDYLTVAGMLCYVLVGCDESDRANSLSIVPTGDS------------CSASCVCEYVYYAPVCS 465

Human   476 NNGITYISPCLAGCKSSSGNK-KPIVFYNCSCL----------EVTGLQNRNYSAHLGECPRDDA 529
            ...||:||.|.|||...:.|: ...::..|.|:          .||.|.:::..|..|.||.|
  Fly   466 PENITFISACHAGCTDKAINELGKTIYTGCRCMGNVSSIISLSNVTSLASQSQIAMDGACPVD-- 528

Human   530 CTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGAL 594
            |.::|..|:|:.....|..|.|.:|:::|.::.|..:.|:.:|||.|||...|..|.:||.||.:
  Fly   529 CNKQFLIFLAVMCFLKFVGATGRSSNLLLALRCVPSKDKTFSLGFGSMVYSVLAFIPSPIVFGWM 593

Human   595 IDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGL--SSMLRVSSLVLYIILIYAMKKKY---QEK 654
            :|:.|:.|. ..|.::|:|..|::.|. |..:.|  :|::.:.|.....:..:|...|.   .||
  Fly   594 LDSYCLVWG-KTCSSKGNCWIYDTKSL-RYTMNLVCASLIFLGSFWNIGVWYHAKDMKVFDEDEK 656

Human   655 DINASENGSV-MDEANLESLNKNK 677
            .:.|.::..: :.|...:.:.|.|
  Fly   657 TVQAKQSDDIELKEKPNDVVTKKK 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO1B1	NP_006437.3	MFS	27..561	CDD:475125	143/550 (26%)
Oatp58Db	NP_611658.3	OATP	53..619	CDD:460821	164/610 (27%)