Protein Alignment SLCO1B1 and Oatp58Da

DIOPT Version :10

• Sequence 1: NP_006437.3
• Gene: SLCO1B1 / 10599
• HGNCID: 10959
• Length: 691
• Species: Homo sapiens
• Sequence 2: NP_611657.2
• Gene: Oatp58Da / 37543
• FlyBaseID: FBgn0050277
• Length: 684
• Species: Drosophila melanogaster
• Alignment Length: 698
• Identity: 174/698 - (24%)
• Similarity: 319/698 - (45%)
• Gaps: 85/698 - (12%)

Human    12 EAQPSENKKTRYCNGL--------------KMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEIS 62
            |.:..:..|..|| |.              .|::....|:....|:.......:|..:|:|::|.
  Fly    37 ETEGEDGGKDTYC-GFWIFKGPSMQRFATEHMYVILYGLAGCVMTMTFAYFNGTITTLEKRYKIP 100

Human    63 SSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKET 127
            :.:.|.|....:|..:|....:.|:....|||:.:|||...:....:||:..||..|
  Fly   101 TKVSGIISVGNDISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFLYG-------- 157

Human   128 NINSSENST------STLSTCLINQILSLNRASPEIVGKGCLKESGSYMW---IYVFMGNMLRGI 183
               :.|::.      ..::..|.||........|  ...||::|... :|   :::|...::.|:
  Fly   158 ---AGEDALQLTREFGQVNETLTNQERDKKLCQP--TAGGCVQEEVG-LWVPQVFLFAAQLISGV 216

Human   184 GETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRIT 248
            |:.....||::|:||...:..:...|.:...:.|:||.||::|.::..::|::.....|    |.
  Fly   217 GQALFYTLGIAYMDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYIEPTLEPL----IG 277

Human   249 PTDSRWVGAWWLNFLVSGLFSIISSIPFFFLP-QTPNKPQKERKASLSLHVLETNDEKDQTANLT 312
            ..|.||:|||||.:||....:::|:|..|..| |.|:    .||..|.|    ..||:.|:..|.
  Fly   278 QEDPRWLGAWWLGWLVLAAITLVSAILLFMFPKQLPS----ARKRRLQL----KQDERKQSLPLN 334

Human   313 NQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANIL 377
            .      :::....::.|.:..|.:||...:.::|....|:..:.:..||:|.||.|.::.|.:.
  Fly   335 E------RSLADMMKTVKKLSKNKVYVYNTMASILYFFGYMVYWIFTPKYIETQYRQSAAMATMA 393

Human   378 LGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKS-VAGLTMT 441
            .|.:.:...|:|:.:.||:|.|:|.:...:|.::.....::::..|.|..|.||... :..||..
  Fly   394 TGTVALGFSAAGILISGYVISKYKPSARAMAAWNAIVDFVTVAGILCYVAIGCEGSDRLNTLTTL 458

Human   442 YDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGC----KSSSGNKKPIVFY 502
            ..||:            |::.|:||...:.|||..:.||:||.|.|||    |.:.|.   .::.
  Fly   459 SAGNS------------CSASCHCDYVHYAPVCSADNITFISACHAGCSERTKDALGR---TIYT 508

Human   503 NCSCLEVTGLQNRNYS--AHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQP 565
            .|.||..:.|.:...|  |..|.||.|  |..:|..|:.:........|...:::::|.::.:.|
  Fly   509 GCECLGSSSLNSEPESQFAVDGTCPVD--CFNEFLIFLGVMCFLKLVGASSKSTNLLLALRCMPP 571

Human   566 ELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSS 630
            :.|:.|||..||....||.|.:||:||.|||..|:.|. ..|..:|:|..|::.|. |..|.||:
  Fly   572 DEKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLVWG-KTCSNKGNCWLYDTKSM-RYALNLSA 634

Human   631 --MLRVSSLVLYIILIYAMKKKYQEKDINASENGSVMDEANLESLNKN 676
              .:.:...:...:..:|...|..:::.::.::.....|..:::::.|
  Fly   635 AFFIFLGGFLNIAVWYHAKNLKIFDEEESSPKDSLKNKEVEMKTIDSN 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO1B1	NP_006437.3	MFS	27..561	CDD:475125	137/564 (24%)
Oatp58Da	NP_611657.2	OATP	67..626	CDD:460821	160/608 (26%)