Protein Alignment SLCO1B1 and Oatp33Eb

DIOPT Version :10

• Sequence 1: NP_006437.3
• Gene: SLCO1B1 / 10599
• HGNCID: 10959
• Length: 691
• Species: Homo sapiens
• Sequence 2: NP_609570.1
• Gene: Oatp33Eb / 34662
• FlyBaseID: FBgn0032435
• Length: 814
• Species: Drosophila melanogaster
• Alignment Length: 686
• Identity: 153/686 - (22%)
• Similarity: 273/686 - (39%)
• Gaps: 135/686 - (19%)

Human    23 YCNG--------LKMFLAALSLSFIAKTL-GAIIMKSSIIHIERRFEISSSLVGF--------ID 70
            :|.|        |:.|:..|::|   .|| ||         .|..|.:|:....|        :|
  Fly    34 WCRGPGCQKYARLRTFILVLAIS---GTLQGA---------CESYFRVSAKQASFQFGWNPLIVD 86

Human    71 GSFEIGNLLVIVFV---SYFGSKLHRPK-LIG------IGCFIMGIGGVLTALPHFFMGYYRYSK 125
            .......|...||.   :|:....|..| |:|      :.|.:    .|:.::.:|..|  ..:|
  Fly    87 WLLVASGLFQAVFALAFAYWADVYHPIKWLVGTLMLQAVTCVV----AVIPSIMNFADG--NQAK 145

Human   126 ETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVP 190
            :..::::..:||....    |.|:|..|           :|.|.....:|:..:..|:|......
  Fly   146 DALLDANMCATSLAQF----QRLTLTEA-----------QSSSLTLAMLFVLQLALGMGGLAYYT 195

Human   191 LGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWV 255
            ||:|||||.:....|...:|    .|:...:.|...|| |..:.|.:.:|
  Fly   196 LGVSYIDDNSLSQDSPAVIG----AALAARVFGQQAGS-FLVLGVGLTHV--------------- 240

Human   256 GAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITK 320
             .|||.:::...|..:.::.....|:...|....:.|.   .::|       .:::...|...:.
  Fly   241 -GWWLGWVILAPFIFVGAVLLGLFPKRLPKTVIHQAAQ---RIIE-------QSSMRRFGSQFST 294

Human   321 NV--TGFFQSFKSILTNPLYVMFVLLTL-----------LQVSSYIGAFTYVFKYVEQQYGQPSS 372
            .:  :.|:.|.|.:..|.| :||.||::           ||..||:.: .:...|.||.......
  Fly   295 YMDDSDFWPSLKRLFNNRL-LMFNLLSIMCVQSAVVNYGLQEESYLQS-RFFLPYNEQDGLAAEW 357

Human   373 KANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAG 437
            ::..:...:..|:.|.||.:.|.:|.|.||:...|...:...::..::.::...|:.|:..::||
  Fly   358 RSAFVSYFLKPPVMALGMLISGLVISKAKLSARKITGINIALSIHLVAIFIGLIFVQCDVGAIAG 422

Human   438 LTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVC-GNNGITYISPCLAGCKSSSGNKKPIVF 501
            :    :|..       :...||:|.|.|..:.:.||| .|:.:||.|||.|||...:......:|
  Fly   423 V----EGGK-------LKQPYCSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQLF 476

Human   502 YNCSCLEVTGLQNRNYSAHL----GECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKI 562
            ..|||   :|.|:.|.:..:    |.|..|: |......|..:.:...|...:|.....::.::.
  Fly   477 EGCSC---SGDQSLNSTGQMRATAGACSSDN-CQSAIIIFQIMSISVAFLMGVGAIGKTLITLRA 537

Human   563 VQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTN--NCGTRGSCRTYNSTSFSRVY 625
            |.|:.|||||.|..|::.....:...:.:..:..|||:.|:.|  .|..|.:.:..|........
  Fly   538 VLPQDKSLALAFELMIVGLFAYVPVHLSYDIVTRTTCVYWAPNYERCLLRETPKHGNILDILTAS 602

Human   626 LGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASEN 661
            |.|:|       ||:.||:|...|.....:...::|
  Fly   603 LILAS-------VLFDILVYIFAKGLNLYNCKVTDN 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO1B1	NP_006437.3	MFS	27..561	CDD:475125	124/570 (22%)
Oatp33Eb	NP_609570.1	MFS_SLCO_OATP	46..536	CDD:340894	124/570 (22%)
		PHA03247	<635..813	CDD:223021