DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLCO1B1 and Oatp33Ea

DIOPT Version :9

Sequence 1:	NP_006437.3	Gene:	SLCO1B1 / 10599	HGNCID:	10959	Length:	691	Species:	Homo sapiens
Sequence 2:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster

Alignment Length:	744	Identity:	180/744 - (24%)
Similarity:	315/744 - (42%)	Gaps:	118/744 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    28 KMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLH 92
            |||:....|....:.:..:....::..:|:||:|.|...|.|....||..:::.:.:||.|.:.:
  Fly    35 KMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRN 99

Human    93 RPKLIGIGCFIMGIGGVLTALPHFFMG----YYRYSKE------TNINSSENSTSTLSTCLINQI 147
            ||:.|..|....|:...:..||||..|    ..:::||      .....|::|...:|:....::
  Fly   100 RPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVKTERL 164

Human   148 LSLNRASPEIVGKGCLKESGSYM-WIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGI 211
            ..:::...:     | .:..||: .:.:|:...:.|:|.|....||.:|:||..|:.::.|.|.:
  Fly   165 CGVDKTEDD-----C-DDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAV 223

Human   212 LNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSG-LFSIISSIP 275
            ..|:.||||::||..|.:....::|    ...|..|...|.||:|||||.:::.| |..:.|.:.
  Fly   224 AMALRMIGPVVGFFFGFISLNTFID----PTKTPLIDSKDPRWLGAWWLGWVILGTLMCLFSGLI 284

Human   276 FFFLPQTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGK---NITKNVTG------------- 324
            ..|..|.|........:.|.|.:.:|.:|..:..||:...:   |...:..|
  Fly   285 GLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANADLPKLK 349

Human   325 -FFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFAS 388
             |.::...:|.|.|.:..:|..:..:....|..|::.||:|.|:.:.:..|.|::|.|:|.....
  Fly   350 DFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPISIMGMVV 414

Human   389 GMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTMTYDGNNPVTSHRD 453
            |:...|.::.|.|.:...:..::.....:|:...:.|.|:.|.|.    .:||..|...:||:
  Fly   415 GLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPNT----FSMTQAGQLNLTSN-- 473

Human   454 VPLSYCNSDCNCDESQWEPVCGN-NGITYISPCLAGCKSSSGNKKPIVFYNCSC----------- 506
                 ||.:|:|:...:.|||.. ...|:.|.|.|||:..:...|  ::.:|||
  Fly   474 -----CNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATSK--LYEDCSCVVNDPAPKSAA 531

Human   507 --------------LEVT--------GL----QNRNYSAHL---------------GECPRDDAC 530
                          |:.|        |:    .|.::...|               |.|.::  |
  Fly   532 QRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGICTKN--C 594

Human   531 TRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALI 595
            ...|:.|....::..:|.:.|...:|::..:.|..|.||.|.|...|:|..|..|..||.||.||
  Fly   595 NWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPGPIIFGRLI 659

Human   596 DTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVL-YIILIYAMKKKYQEKDINAS 659
            |:||:.| |..|...|:|:.|:.|.|......||.:|....|:. |::..|.     :..||...
  Fly   660 DSTCLVW-TKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWYYG-----RNLDIYGD 718

Human   660 ENGSVMDEANLESLNKNKHFVPSAGADSE 688
            :.....:.||    .|::...|.....||
  Fly   719 KEAKEEERAN----RKDQPITPLLAKKSE 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLCO1B1	NP_006437.3	OATP	29..621	CDD:281175	164/673 (24%)
		MFS	31..>427	CDD:119392	98/424 (23%)
		KAZAL_SLC21	455..508	CDD:238650	17/78 (22%)
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	164/673 (24%)
		MFS	40..>280	CDD:119392	64/249 (26%)
		DUF4064	364..447	CDD:290013	17/82 (21%)
		KAZAL_SLC21	470..521	CDD:238650	18/59 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820