DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLCO1B1 and Oatp30B

DIOPT Version :9

Sequence 1:	NP_006437.3	Gene:	SLCO1B1 / 10599	HGNCID:	10959	Length:	691	Species:	Homo sapiens
Sequence 2:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster

Alignment Length:	745	Identity:	240/745 - (32%)
Similarity:	380/745 - (51%)	Gaps:	111/745 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    27 LKMFLAALS-LSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSK 90
            :|:|:..|| |..:.:.|.:..:.|.|..||:||||.||..|.|..|:||||::.::||||.||:
  Fly   169 IKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSR 233

Human    91 LHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETN-----INSSENSTSTLSTCLINQILSL 150
            .|.|..||||..|||||.::..:|||       :.|.|     :|.:.::... |..:.:|.:.|
  Fly   234 RHIPVWIGIGAVIMGIGSLVFMVPHF-------TGEPNPGIAIVNKTSDNICK-SALVRDQDMDL 290

Human   151 NRASPEIVGK----------GCLKESGSY---MWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKE 202
            .|.|..:..:          .||:...|.   :.::| :..:|.|.|.:|:..||.:|:||..:.
  Fly   291 GRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVLLFV-LAQLLLGCGGSPLFTLGTTYVDDHVRT 354

Human   203 GHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGL 267
            ..||:|:|.:.::...||::||.||:.....::|  .:..:||.|||.|.||||.||..||:.|:
  Fly   355 ESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTISITPGDRRWVGMWWGGFLLCGV 417

Human   268 FSIISSIPFFFLPQTPNKPQKE-RKASLSLHVLETN-------DEKDQTANL------------- 311
            ..::.::|||..|:...:.:|: ||:|:...||..|       ||..:...|
  Fly   418 ILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVAVTSKEDQSQ 482

Human   312 ------TNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQP 370
                  |..||:| |::.   ||...::.||:|::..|...:::....|...::.||:|.|:...
  Fly   483 APPKVDTGYGKDI-KDIP---QSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLG 543

Human   371 SSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSV 435
            .|:|||..|.|.:|....|:||||.|:|:|:|...|..:|...|.|:.|:.|.:.||:.|:|..:
  Fly   544 KSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKM 608

Human   436 AGLTMTYDGNNPVTSHRDVPL-----SYCNSDCNCDESQWEPVCGNNGITYISPCLAGCK--SSS 493
            ||.|:.|..:|...|..:.|.     :.||..|.|..|:.||||||||:||.|||.|||.  ||:
  Fly   609 AGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCGNNGLTYFSPCHAGCTAFSST 673

Human   494 GNKKPIVFYNCSCLEVT----------GLQ------NRNYS-------AHLGECPRDDACTRKFY 535
            .|..   :.||:|:...          |.|      |.|::       |..|.|.  ..| |..|
  Fly   674 SNTN---YTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVPVATAGPCA--TPC-RTIY 732

Human   536 FFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCI 600
            .|:.:.....|..|......:|::::.|..|.:|.|||...::.|..|.|.|||.||.|||:|||
  Fly   733 PFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLIDSTCI 797

Human   601 KWSTNNCGTRGS-CRTYNSTSFSRVYLGLSSMLRVSSLVLYII---LIYAMKKKYQEKDINASEN 661
            .|. ::||.:|. |..|:...|...|:||.:.:::.:||::::   |:...|:..:.|.:|||:.
  Fly   798 LWK-SSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWWLVRRRKQLEKMKPLNASDP 861

Human   662 --GSVMDEANLESLNKNKHFVPSAGADSET 689
              ||::   :|:.|.:.|    .:||:..|
  Fly   862 IIGSII---SLDKLFEEK----LSGAEPST 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLCO1B1	NP_006437.3	OATP	29..621	CDD:281175	219/668 (33%)
		MFS	31..>427	CDD:119392	140/441 (32%)
		KAZAL_SLC21	455..508	CDD:238650	28/59 (47%)
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	219/668 (33%)
		MFS	174..>433	CDD:119392	92/269 (34%)
		MFS	512..>600	CDD:304372	28/87 (32%)
		KAZAL_SLC21	633..684	CDD:238650	26/53 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810