Protein Alignment SLCO1B1 and Oatp26F

DIOPT Version :9

• Sequence 1: NP_006437.3
• Gene: SLCO1B1 / 10599
• HGNCID: 10959
• Length: 691
• Species: Homo sapiens
• Sequence 2: NP_609055.2
• Gene: Oatp26F / 33927
• FlyBaseID: FBgn0051634
• Length: 692
• Species: Drosophila melanogaster
• Alignment Length: 622
• Identity: 185/622 - (29%)
• Similarity: 311/622 - (50%)
• Gaps: 65/622 - (10%)

Human    47 IMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSK--LHRPKLIGIGCFIMGIGGV 109
            ::..||..|||||.:.|..:|.:...:::.:...:|.|:|:|.:  ..:|:.|.||..:||:|.:
  Fly    85 LINVSISTIERRFGLRSRQMGLVASGYDLASFACLVPVTYYGGRRGASKPRFIAIGLIVMGMGSL 149

Human   110 LTALPHFFMGYYRYS-------KETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESG 167
            :..||:|.:|.||.:       :.|.:..:.||:.:::.|.:|           .:|:|   :|.
  Fly   150 VFLLPNFLVGNYRATIAEANVCETTGLPFNSNSSQSMTACELN-----------AMGEG---QSE 200

Human   168 SYMW-IYVFM-GNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLF 230
            :..| :::|: ..:|.|.|.:|:..||::|||:...:..||:||||...:|.:||.||:..|...
  Fly   201 NLTWTVWLFLAAQLLHGAGASPLFTLGVTYIDENVSKKMSSVYLGIYYTMATVGPAIGYVFGGQL 265

Human   231 SKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQT---PNKPQKERKA 292
            ..:|.|...||...:.:|.....|:|||||.|:.:....::.::|.|..|:.   ..|.|.||.:
  Fly   266 LLIYTDWMTVDPVQLSLTSDSKVWIGAWWLGFIFAAAMCLLIALPIFGYPKLLPGAEKLQLERVS 330

Human   293 SLSLHVLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFT 357
              ..|.  |..|.|.::|:          |.|..::..|:|.||.:....|....:.....|...
  Fly   331 --EAHA--TISEADDSSNV----------VRGLPRAVLSLLANPTFFFLNLAGATEGLVIAGFAA 381

Human   358 YVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFY 422
            ::.|.:|.|:......:.:::|:||:|....|.|||||::||:.|...||.|. |..|....:.:
  Fly   382 FLPKQIENQFSISPMYSALVMGLITVPAGGGGTFLGGYLVKKWNLACRGIIKM-CLLATTVAALF 445

Human   423 LLYFFILCENKSVAGLTMTYDGNNPVTSHRDVP--LSYCNSDCNCDESQWEPVCGNNGITYISPC 485
            .:.|.:.|.|...||:|..|    .:....|.|  ::.|||:|.|..:.::|:||.:|:.|.|||
  Fly   446 TICFLVSCPNPKFAGVTTGY----KMQPSSDSPALVASCNSNCGCSRTNYDPICGVDGVMYYSPC 506

Human   486 LAGCKSSSGNKKPIVFYNCSCLEVTG-LQNRNYSAHLGECP--RDDACTRK-------FYFFVAI 540
            .|||...........::||||:|..| :.:.|.|:   |.|  |.||..||       ...|||:
  Fly   507 YAGCVQEEHANSLKRYHNCSCIEQVGFVDDGNPSS---EAPHFRPDATNRKCDSTCQTLPLFVAL 568

Human   541 QVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTN 605
            ..:.:.|:.|.....:...::.||.:.:|.|||...:.:|.||.|.||:.||||||.:||.|. .
  Fly   569 CFILMVFTFLATMPALSATLRCVQDDQRSFALGLQWIKVRLLGTIPAPLIFGALIDESCILWQ-E 632

Human   606 NC--GTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLY 640
            :|  ...|:|..|::...||....|:.:.::.|:|.:
  Fly   633 SCDKDAGGACLVYDNFYISRYMWLLALICKLGSVVFF 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO1B1	NP_006437.3	OATP	29..621	CDD:281175	180/601 (30%)
		MFS	31..>427	CDD:119392	110/393 (28%)
		KAZAL_SLC21	455..508	CDD:238650	21/54 (39%)
Oatp26F	NP_609055.2	OATP	66..647	CDD:281175	180/598 (30%)
		MFS	69..>318	CDD:119392	72/246 (29%)
		KAZAL_SLC21	476..529	CDD:238650	20/52 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810