DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERN2 and IRE1

DIOPT Version :9

Sequence 1:	NP_150296.4	Gene:	ERN2 / 10595	HGNCID:	16942	Length:	926	Species:	Homo sapiens
Sequence 2:	NP_011946.1	Gene:	IRE1 / 856478	SGDID:	S000001121	Length:	1115	Species:	Saccharomyces cerevisiae

Alignment Length:	1084	Identity:	301/1084 - (27%)
Similarity:	460/1084 - (42%)	Gaps:	296/1084 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    32 VHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDD---PVIE----GPMYVTEMAFLSDPADGS 89
            ::.|...::|:.:.::|.|||:.::.|.:.|::..:   |:||    ..:...|...:....||:
Yeast   114 LNELSLSDILIAADVEGGLHAVDRRNGHIIWSIEPENFQPLIEIQEPSRLETYETLIIEPFGDGN 178

Human    90 LYILGTQKQQGLMKLPFTIPELVHASPCR-------------SSDGVFYTGRKQDAWFVVDPESG 141
            :|....  .|||.|||.:|.:||..||..             ..|...|||..:...:.::..:|
Yeast   179 IYYFNA--HQGLQKLPLSIRQLVSTSPLHLKTNIVVNDSGKIVEDEKVYTGSMRTIMYTINMLNG 241

Human   142 ETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGM 206
            |   .::..||.:...|.|                          :..:|.||.:.:. |..|..
Yeast   242 E---IISAFGPGSKNGYFG--------------------------SQSVDCSPEEKIK-LQECEN 276

Human   207 GLLL----------TVDPGSGTV---LWTQD-LGVPVMGVYTWHQDGLRQLP--HLTLARDTLHF 255
            .:::          :.|..|..|   .|.|: |.||:....|:.:||:...|  ..:|....|.|
Yeast   277 MIVIGKTIFELGIHSYDGASYNVTYSTWQQNVLDVPLALQNTFSKDGMCIAPFRDKSLLASDLDF 341

Human   256 LALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPA 320
            ...||.....|.                    :.||.    |.|...|......|||........
Yeast   342 RIARWVSPTFPG--------------------IIVGL----FDVFNDLRTNENILVPHPFNPGDH 382

Human   321 DGPTTDEVTL-QVSG------EREGSPSTAVRYPSGSVALPSQW--------------LLIGHHE 364
            :..::::|.| |.|.      ..:..||.....|....|...:|              .::|.|:
Yeast   383 ESISSNKVYLDQTSNLSWFALSSQNFPSLVESAPISRYASSDRWRVSSIFEDETLFKNAIMGVHQ 447

Human   365 L------------------------PPVL-----HTTMLRVHPTLGSGTAETRPPENTQAPAFFL 400
            :                        ||::     .||.|..:..:.| ..|...||:.:|
Yeast   448 IYNNEYDHLYENYEKTNSLDTTHKYPPLMIDSSVDTTDLHQNNEMNS-LKEYMSPEDLEA----- 506

Human   401 ELLSLSREKLWDS---ELHPEEKTPDSYLGLGPQDLLAASL------TAVLLGGWILF------- 449
                 .|:|:.:.   ||  :||..:|.|      |...||      |.|.|..:::|
Yeast   507 -----YRKKIHEQISREL--DEKNQNSLL------LKFGSLVYRIIETGVFLLLFLIFCAILQRF 558

Human   450 --------------VMRQQQPQVVEKQ-------QETPLAPADFAHISQ---------------- 477
                          .|.:::..:||.:       .|....|.|.....|
Yeast   559 KILPPLYVLLSKIGFMPEKEIPIVESKSLNCPSSSENVTKPFDMKSGKQVVFEGAVNDGSLKSEK 623

Human   478 --------DAQSLHSGASRRSQKRLQSPSKQAQ-------PLDDPEAEQLTVVGKISFNPKDVLG 527
                    |.:||.....::.:||.....|:.:       |..:...:.|.|..||       ||
Yeast   624 DNDDADEDDEKSLDLTTEKKKRKRGSRGGKKGRKSRIANIPNFEQSLKNLVVSEKI-------LG 681

Human   528 RGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALE 592
            .|:.||.||:|.|:||.|||||:|.:...:...|::||.|||.||||:||:|:|...:|.|||||
Yeast   682 YGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLYIALE 746

Human   593 LCRASLQEYVENPDLDRGGLE------PEVVLQQLMSGLAHLHSLHIVHRDLKPGNILI------ 645
            ||..:||:.||:.::....|:      |..:|:|:.||:||||||.|:||||||.|||:
Yeast   747 LCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRF 811

Human   646 -----TGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIP-GTEGWMAPELLQ----------- 693
                 ||.::.   |:::|||||||||.:|:.||..:...| ||.||.|||||:
Yeast   812 TADQQTGAENL---RILISDFGLCKKLDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQCQVET 873

Human   694 --------LLPPDS---P------TSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCL 741
                    ::..||   |      |.::||||.||||||:||.|.|||||...|::||:.|   :
Yeast   874 EHSSSRHTVVSSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRG---I 935

Human   742 AHLEEE--VHDKVV---ARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKE 801
            ..|:|.  :||:.:   |.||:..|:...|..||:|.:||.||.||.::|:|:|...|||.||.|
Yeast   936 FSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFLLKVSDRLEIE 1000

Human   802 SEQEP--LVRALEAGGCAVV-RDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYREL 863
            :...|  |:...:||...|: ..:|..........:|.::|.|..:.:.|||||:|||.||:.:|
Yeast  1001 NRDPPSALLMKFDAGSDFVIPSGDWTVKFDKTFMDNLERYRKYHSSKLMDLLRALRNKYHHFMDL 1065

Human   864 PVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFL 907
            |.::.:.:|.|||||..|||.|||.||:..:..::...|:...|
Yeast  1066 PEDIAELMGPVPDGFYDYFTKRFPNLLIGVYMIVKENLSDDQIL 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERN2	NP_150296.4	Luminal_IRE1	38..366	CDD:188875	77/408 (19%)
		PQQ	<41..237	CDD:224437	49/229 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..509		7/37 (19%)
		STKc_IRE1	517..782	CDD:270884	134/315 (43%)
		S_TKc	520..781	CDD:214567	132/311 (42%)
		RNase_Ire1	785..910	CDD:199217	46/126 (37%)
IRE1	NP_011946.1	Luminal_IRE1	120..407	CDD:188875	70/342 (20%)
		STKc_IRE1	672..981	CDD:270884	136/321 (42%)
		RNase_Ire1	984..1113	CDD:199217	46/126 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159045909
Domainoid	1	1.000	171	1.000	Domainoid score	I876
eggNOG	1	0.900	-	-		E2759_KOG1027
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	379	1.000	Inparanoid score	I398
Isobase	1	0.950	-	0	Normalized mean entropy	S2441
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001857
OrthoInspector	1	1.000	-	-		otm53287
orthoMCL	1	0.900	-	-		OOG6_102150
Panther	1	1.100	-	-	LDO	PTHR13954
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2163
SonicParanoid	1	1.000	-	-		X1217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.730