DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERN2 and ern2

DIOPT Version :9

Sequence 1:	NP_150296.4	Gene:	ERN2 / 10595	HGNCID:	16942	Length:	926	Species:	Homo sapiens
Sequence 2:	NP_001072279.1	Gene:	ern2 / 779732	XenbaseID:	XB-GENE-4594134	Length:	957	Species:	Xenopus tropicalis

Alignment Length:	966	Identity:	511/966 - (52%)
Similarity:	639/966 - (66%)	Gaps:	83/966 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     8 SRPWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEG 72
            |.||  |.|.|.|.:..|...........||:||.||||||:|||:||::|.:.|||:|||||:.
Frog     6 SHPW--LWLILAFFSAHLLQCDAGASVSLPESLLFVSTLDGNLHAVSKRSGTVLWTLKDDPVIQV 68

Human    73 PMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVD 137
            |:||:|.|||.||:||||||||.:.::|||||||||||||.:||||||||:.|||:|||||||||
Frog    69 PLYVSEPAFLPDPSDGSLYILGGRNKEGLMKLPFTIPELVQSSPCRSSDGILYTGKKQDAWFVVD 133

Human   138 PESGETQMTLTTEG-----PSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKY 197
            |:|||.|.||:||.     ||:|.||||||||.:||:|.::..||||.|:..||||..|.:....
Frog   134 PKSGEKQTTLSTESSEGLCPSSPLLYIGRTQYMITMYDTKSRELRWNATFHDYSAPMCDETYDYK 198

Human   198 MSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGH 262
            |:|..|.|.|||:|.|..||.|||.|:.|.||:|::.||||.||::|||.:|.:||.:|......
Frog   199 MAHFTSTGDGLLVTADRNSGEVLWMQNYGSPVIGLFLWHQDSLRRIPHLNVASETLRYLTFHSHD 263

Human   263 IRLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDE 327
            |||.....:....|.|| .|.||.:|||||..||||.:.:::|.|||:||||:|||..|||||.:
Frog   264 IRLIKWNYQAVQQLSST-KTHLLPSLYVGKHVTGFYATSSMIHEGVAVVPRGITLARVDGPTTQD 327

Human   328 VTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPPEN 392
            |||:.|.:.:.:.:|.|:||.|||....|||||||||||||:||||||..|.......||
Frog   328 VTLKESTKFDVTSNTDVKYPQGSVISAHQWLLIGHHELPPVVHTTMLRAFPETLRRDTET----- 387

Human   393 TQAPAFFLELLSLSREKLWDSELHPEEK---------------TPDSYLGLGPQD-----LLAAS 437
                    .:...|...|:|..|.|:.:               |......:.|.|     :|...
Frog   388 --------IIRGSSPRTLFDDFLTPQNQDGLSQGDTERRIKVDTSKEEANMVPTDSSVMNVLLGI 444

Human   438 LTAVLLGGWILFVM----------RQQQP---------QVVEKQQ----ETPLAP-----ADFAH 474
            :..:|||||:||..          ||||.         |:::.||    |.|.:|     |..:.
Frog   445 IFTLLLGGWVLFAFTYPKMQEQQRRQQQELQQELEKKLQLLQNQQNLASEVPPSPGHSGSAQTSF 509

Human   475 ISQDAQSLHSGASRRS----------QKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRG 529
            :|::..|..|..||.|          .::|:..|.:::..|..|..    ||||||:||||||.|
Frog   510 LSEEQDSRQSSGSRASGQLDGVQTNGTRKLRKESVESEVNDGDEIR----VGKISFSPKDVLGHG 570

Human   530 AGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELC 594
            ||||.||||:|:.|||||||:|.|.|.|..||||||:|||.||||:||:|||....|.|||||||
Frog   571 AGGTCVFRGKFDDRAVAVKRILSESFTLADREVQLLRESDEHPNVIRYYCTESDKLFCYIALELC 635

Human   595 RASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLS 659
            ..:||||::||||.|.||:...:|.|.||||||||||:||||||||.||||:.|.:.|..|.|:|
Frog   636 ATTLQEYMKNPDLHRSGLDSVTLLHQTMSGLAHLHSLNIVHRDLKPCNILISYPSAHGKVRAVIS 700

Human   660 DFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPF 724
            ||||||||..||.||||.|||||||||:|||:|:..|..:||:||||||||||||||||.|.|||
Frog   701 DFGLCKKLSVGRNSFSLRSGIPGTEGWIAPEVLRDRPKQNPTAAVDIFSAGCVFYYVLSKGQHPF 765

Human   725 GDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQ 789
            ||:|.||:|||:|:..|..|:|:.|:.||||.||..|::.....||:|..||.|||||:.||:||
Frog   766 GDNLRRQSNILSGSYSLPKLQEDTHENVVARHLVEMMINCDSLLRPTAEHVLIHPFFWAPAKRLQ 830

Human   790 FFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVR 854
            |||||||.:|||..:.|:|.|||:...:|||.||..|||:||||||||||||:|.||||||||:|
Frog   831 FFQDVSDRIEKEPAESPIVVALESDARSVVRVNWRLHISVPLQTDLRKFRSYRGNSVRDLLRAMR 895

Human   855 NKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYY 910
            ||||||.|||.:|::.||.:||.||.||::|||.|||||::|:..|:.|..|..||
Frog   896 NKKHHYHELPADVQETLGSIPDEFVSYFSSRFPYLLLHTYQALEQCSPERQFQTYY 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERN2	NP_150296.4	Luminal_IRE1	38..366	CDD:188875	192/332 (58%)
		PQQ	<41..237	CDD:224437	124/200 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..509		8/40 (20%)
		STKc_IRE1	517..782	CDD:270884	175/264 (66%)
		S_TKc	520..781	CDD:214567	171/260 (66%)
		RNase_Ire1	785..910	CDD:199217	79/124 (64%)
ern2	NP_001072279.1	Luminal_IRE1	34..302	CDD:188875	156/268 (58%)
		STKc_IRE1	558..823	CDD:270884	175/264 (66%)
		RNase_Ire1	826..951	CDD:199217	79/124 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48078
OrthoDB	1	1.010	-	-		D1019877at2759
OrthoFinder	1	1.000	-	-		FOG0001857
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13954
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.030