Protein Alignment ERN2 and Ern2

DIOPT Version :10

• Sequence 1: NP_150296.4
• Gene: ERN2 / 10595
• HGNCID: 16942
• Length: 926
• Species: Homo sapiens
• Sequence 2: XP_011240119.1
• Gene: Ern2 / 26918
• MGIID: 1349436
• Length: 919
• Species: Mus musculus
• Alignment Length: 927
• Identity: 750/927 - (80%)
• Similarity: 804/927 - (86%)
• Gaps: 21/927 - (2%)

Human     1 MASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLR 65
            ||..|:..:.|..||..||... |||.|.|||.::|||:||.|||||||||||:|||||||||::
Mouse     1 MARPVQRFQLWSPLGFLLQLVT-LLGKLGPQVQSVRPESLLFVSTLDGSLHALNKQTGDLKWTVK 64

Human    66 DDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQ 130
            |||:|:||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
Mouse    65 DDPIIQGPMYVTEMAFLSDPADGSLYVLGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQ 129

Human   131 DAWFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPG 195
            |||||||||||||||||||||.|||:|:||||||||:|||.|.|||||||||||||||.::||||
Mouse   130 DAWFVVDPESGETQMTLTTEGLSTPQLFIGRTQYTVSMHDLRTPALRWNTTYRRYSAPLLNGSPG 194

Human   196 KYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRW 260
            ||||||.|||||||||||||||.|||||||||||.|:||||||||.|||||||||||||||.|||
Mouse   195 KYMSHLTSCGMGLLLTVDPGSGIVLWTQDLGVPVTGIYTWHQDGLHQLPHLTLARDTLHFLVLRW 259

Human   261 GHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTT 325
            ||||||||..:||||.||:|||||||||||||:|.||||||||||.|||||||||||||.|||||
Mouse   260 GHIRLPASSYQDTATQFSSLDTQLLMTLYVGKEEAGFYVSKALVHAGVALVPRGLTLAPMDGPTT 324

Human   326 DEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP 390
            ||||||||||||||||||||||||||||||||||||:||.|||||||||||||..|..:||||..
Mouse   325 DEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGYHEPPPVLHTTMLRVHPIPGKVSAETRAS 389

Human   391 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQ 455
            |:..||..|.|||:|.||   |.|||||||..|||.|||.||||||:.||:|||.|:|::|||
Mouse   390 EDLHAPPVFFELLNLRRE---DPELHPEEKASDSYPGLGSQDLLAATFTAILLGAWVLYLMRQ-- 449

Human   456 PQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISF 520
                  ||::|.|||....:|||||...|....:.|:|.||||:.|||..||||.|.||||||||
Mouse   450 ------QQQSPSAPAGPPDLSQDAQGQLSRDILQDQRRFQSPSEPAQPPHDPEAGQPTVVGKISF 508

Human   521 NPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQ 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||
Mouse   509 NPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTEHGPQ 573

Human   586 FHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDS 650
            |||||||||:||||||||:|||||.||||..||||:|||||||||||||||||||.|||:.||||
Mouse   574 FHYIALELCQASLQEYVESPDLDRWGLEPTTVLQQMMSGLAHLHSLHIVHRDLKPANILMAGPDS 638

Human   651 QGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYY 715
            ||.||||:||||||||||.|||||||||||||||||||||||| |||||||||||||||||||||
Mouse   639 QGQGRVVISDFGLCKKLPVGRCSFSLHSGIPGTEGWMAPELLQ-LPPDSPTSAVDIFSAGCVFYY 702

Human   716 VLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPF 780
            ||||||||||:|||||||||:|.||||.|:||.||||||.|||.||||.|||.||||..|||||.
Mouse   703 VLSGGSHPFGESLYRQANILSGDPCLAQLQEETHDKVVALDLVRAMLSLLPQDRPSAGWVLAHPL 767

Human   781 FWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTS 845
            ||||||:||||||||||||||.:|.|||.|||||...|||::||:|||.|||.||::||||||||
Mouse   768 FWSRAKELQFFQDVSDWLEKEPDQGPLVSALEAGSYKVVREDWHKHISAPLQADLKRFRSYKGTS 832

Human   846 VRDLLRAVRNK--------KHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCAS 902
            |||||||:|||        ||||||||.||||.|||:|.||:||||.||||||||||||||:|||
Mouse   833 VRDLLRAMRNKDPCPARPQKHHYRELPAEVRQTLGQLPAGFIQYFTQRFPRLLLHTHRAMRTCAS 897

Human   903 ESLFLPYYPPDSEARRP 919
            ||||||||||..|||||
Mouse   898 ESLFLPYYPPALEARRP 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERN2	NP_150296.4	Luminal_IRE1	38..366	CDD:188875	294/327 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	478..509		15/30 (50%)
		STKc_IRE1	517..782	CDD:270884	237/264 (90%)
		RNase_Ire1	785..910	CDD:199217	101/132 (77%)
Ern2	XP_011240119.1	Luminal_IRE1	37..365	CDD:188875	294/327 (90%)
		STKc_IRE1	505..769	CDD:270884	237/264 (90%)
		RNase_Ire1	772..905	CDD:199217	101/132 (77%)