DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERN2 and Ern2

DIOPT Version :9

Sequence 1:	NP_150296.4	Gene:	ERN2 / 10595	HGNCID:	16942	Length:	926	Species:	Homo sapiens
Sequence 2:	XP_011240119.1	Gene:	Ern2 / 26918	MGIID:	1349436	Length:	919	Species:	Mus musculus

Alignment Length:	927	Identity:	750/927 - (80%)
Similarity:	804/927 - (86%)	Gaps:	21/927 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLR 65
            ||..|:..:.|..||..||... |||.|.|||.::|||:||.|||||||||||:|||||||||::
Mouse     1 MARPVQRFQLWSPLGFLLQLVT-LLGKLGPQVQSVRPESLLFVSTLDGSLHALNKQTGDLKWTVK 64

Human    66 DDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQ 130
            |||:|:||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
Mouse    65 DDPIIQGPMYVTEMAFLSDPADGSLYVLGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQ 129

Human   131 DAWFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPG 195
            |||||||||||||||||||||.|||:|:||||||||:|||.|.|||||||||||||||.::||||
Mouse   130 DAWFVVDPESGETQMTLTTEGLSTPQLFIGRTQYTVSMHDLRTPALRWNTTYRRYSAPLLNGSPG 194

Human   196 KYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRW 260
            ||||||.|||||||||||||||.|||||||||||.|:||||||||.|||||||||||||||.|||
Mouse   195 KYMSHLTSCGMGLLLTVDPGSGIVLWTQDLGVPVTGIYTWHQDGLHQLPHLTLARDTLHFLVLRW 259

Human   261 GHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTT 325
            ||||||||..:||||.||:|||||||||||||:|.||||||||||.|||||||||||||.|||||
Mouse   260 GHIRLPASSYQDTATQFSSLDTQLLMTLYVGKEEAGFYVSKALVHAGVALVPRGLTLAPMDGPTT 324

Human   326 DEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP 390
            ||||||||||||||||||||||||||||||||||||:||.|||||||||||||..|..:||||..
Mouse   325 DEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGYHEPPPVLHTTMLRVHPIPGKVSAETRAS 389

Human   391 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQ 455
            |:..||..|.|||:|.||   |.|||||||..|||.|||.||||||:.||:|||.|:|::|||
Mouse   390 EDLHAPPVFFELLNLRRE---DPELHPEEKASDSYPGLGSQDLLAATFTAILLGAWVLYLMRQ-- 449

Human   456 PQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISF 520
                  ||::|.|||....:|||||...|....:.|:|.||||:.|||..||||.|.||||||||
Mouse   450 ------QQQSPSAPAGPPDLSQDAQGQLSRDILQDQRRFQSPSEPAQPPHDPEAGQPTVVGKISF 508

Human   521 NPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQ 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||
Mouse   509 NPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTEHGPQ 573

Human   586 FHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDS 650
            |||||||||:||||||||:|||||.||||..||||:|||||||||||||||||||.|||:.||||
Mouse   574 FHYIALELCQASLQEYVESPDLDRWGLEPTTVLQQMMSGLAHLHSLHIVHRDLKPANILMAGPDS 638

Human   651 QGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYY 715
            ||.||||:||||||||||.|||||||||||||||||||||||| |||||||||||||||||||||
Mouse   639 QGQGRVVISDFGLCKKLPVGRCSFSLHSGIPGTEGWMAPELLQ-LPPDSPTSAVDIFSAGCVFYY 702

Human   716 VLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPF 780
            ||||||||||:|||||||||:|.||||.|:||.||||||.|||.||||.|||.||||..|||||.
Mouse   703 VLSGGSHPFGESLYRQANILSGDPCLAQLQEETHDKVVALDLVRAMLSLLPQDRPSAGWVLAHPL 767

Human   781 FWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTS 845
            ||||||:||||||||||||||.:|.|||.|||||...|||::||:|||.|||.||::||||||||
Mouse   768 FWSRAKELQFFQDVSDWLEKEPDQGPLVSALEAGSYKVVREDWHKHISAPLQADLKRFRSYKGTS 832

Human   846 VRDLLRAVRNK--------KHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCAS 902
            |||||||:|||        ||||||||.||||.|||:|.||:||||.||||||||||||||:|||
Mouse   833 VRDLLRAMRNKDPCPARPQKHHYRELPAEVRQTLGQLPAGFIQYFTQRFPRLLLHTHRAMRTCAS 897

Human   903 ESLFLPYYPPDSEARRP 919
            ||||||||||..|||||
Mouse   898 ESLFLPYYPPALEARRP 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERN2	NP_150296.4	Luminal_IRE1	38..366	CDD:188875	294/327 (90%)
		PQQ	<41..237	CDD:224437	175/195 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..509		15/30 (50%)
		STKc_IRE1	517..782	CDD:270884	237/264 (90%)
		S_TKc	520..781	CDD:214567	234/260 (90%)
		RNase_Ire1	785..910	CDD:199217	101/132 (77%)
Ern2	XP_011240119.1	Luminal_IRE1	37..365	CDD:188875	294/327 (90%)
		STKc_IRE1	505..769	CDD:270884	237/264 (90%)
		RNase_Ire1	772..905	CDD:199217	101/132 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83969707
Domainoid	1	1.000	802	1.000	Domainoid score	I2835
eggNOG	1	0.900	-	-		E2759_KOG1027
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22687
Inparanoid	1	1.050	1506	1.000	Inparanoid score	I2988
Isobase	1	0.950	-	0	Normalized mean entropy	S2441
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48078
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001857
OrthoInspector	1	1.000	-	-		oto126788
orthoMCL	1	0.900	-	-		OOG6_102150
Panther	1	1.100	-	-	LDO	PTHR13954
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2163
SonicParanoid	1	1.000	-	-		X1217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.240