DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERN2 and ire1

DIOPT Version :9

Sequence 1:	NP_150296.4	Gene:	ERN2 / 10595	HGNCID:	16942	Length:	926	Species:	Homo sapiens
Sequence 2:	NP_593384.1	Gene:	ire1 / 2542776	PomBaseID:	SPAC167.01	Length:	1072	Species:	Schizosaccharomyces pombe

Alignment Length:	1060	Identity:	296/1060 - (27%)
Similarity:	453/1060 - (42%)	Gaps:	262/1060 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    39 NLLLVSTLDGSLHALSKQTGDLKWTL-----------RDDPVIEGPMYVTE-------------- 78
            |..:|:|:|||||:..:.||...|:|           :|:..:....::::
pombe    83 NAFIVATVDGSLHSYDRITGQELWSLFTNANPGLSYTKDENSLLSSKFLSQSNFKSYNSTHGEFY 147

Human    79 ------MAFLSD--------PADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRK 129
                  :::|||        |.||.: :.....|.||::||.:|.:||||||.|..:...:.|.|
pombe   148 SDSTLNISYLSDDDTVWFVEPIDGGI-LYAFNLQTGLVRLPHSIKDLVHASPIRLLNNNVFVGSK 211

Human   130 QDAWFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGS- 193
            ....|.:|..:|:    :.::.||..|.   .|.::|  |         |...:|.|.|....|
pombe   212 NTTLFTIDVSNGD----IVSQYPSGHRY---ETHHSV--H---------NLGTKRDSVPSGADSD 258

Human   194 ------PGKYMSHLASCGMGLL-----------------------LTVDPGSGTVL------WTQ 223
                  .||.:|.    .:.||                       :|:...|..:|      ||
pombe   259 LSFKDPSGKKLSE----SLDLLDDFNYQVTVSNKSFVDIARTEYFITIYSDSNVILDLVYIDWT- 318

Human   224 DLGVPVMG--VY-TWHQDGLRQLPHLTLARDTLHFLALRWGHIR--LPASGPRDTATLFSTLDTQ 283
                |...  :| ::|.........|:....:||.:......|:  :|...|  .||:|.
pombe   319 ----PTKNEIMYESFHSSSFDSKLALSSYDSSLHIVDTHSKFIKQNIPLMSP--AATVFD----- 372

Human   284 LLMTL----YVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPT-------------------- 324
             ::||    .:.|.:|                       ||..||
pombe   373 -IVTLPHNKKIDKSQT-----------------------PAKFPTSVLLRQPIDTYLETMFPQIA 413

Human   325 ---TDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPP----VLHTTMLRVHPTLG- 381
               |:.|.:...|....:.|.. .||..|:|..:.:|......:|.    .||:.|....|...
pombe   414 RNKTEHVYINHIGNAWFAMSER-HYPLVSLAPEASFLYYNGFYIPLNSIFGLHSLMATPKPFFAL 477

Human   382 SGTAETRPPENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGW 446
            .|......|...::......|.|:.::.:...:.:|...||.| :.......|:.|.|.|..  :
pombe   478 PGLPGYDIPSYVESEGSTKTLPSIGKKPIPLLDPNPISSTPIS-ITFWVIMFLSVSFTIVTF--F 539

Human   447 ILFVMRQQQPQVVEKQQETPLAPADFAHIS-----------------QDAQSLHSGASRRSQKRL 494
            .:..:|..:.:.::.|:.|         :|                 :.....||.:|..::...
pombe   540 SILRIRSSEVRPLKSQKNT---------VSINNKIDTSKRRRKGKRRKRVSDEHSASSNFNEIES 595

Human   495 QSPSKQAQPLD--------------DPEAEQL-----------TVV----GKISFNP----KDVL 526
            |:..:|.|.||              ||..:.|           ||:    |.::.|.    .:|:
pombe   596 QASFEQNQTLDILSENIVEIQDKSTDPLQKSLDSSLKSHLPEATVIQNTDGSVTVNSLTVYPEVI 660

Human   527 GRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIAL 591
            |.|:.||.|:||.:|.|.|||||:|.|.:.|..||:.|||:||.|||::||:|.::..||.||.:
pombe   661 GYGSHGTIVYRGVYEDREVAVKRVLMEFYDLASREITLLQQSDNHPNIVRYYCKQKSDQFLYIVI 725

Human   592 ELCRASLQEYVENP----DLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQG 652
            |||:.:|.:.:|.|    ||.: .::...:|.|:..|::|||||.:|||||||.|||:...:|..
pombe   726 ELCKCNLSDLIEKPIAYDDLFK-SIDLVSLLYQIAFGVSHLHSLDLVHRDLKPQNILLVVNNSPN 789

Human   653 LG----RVVLSDFGLCKKLPAGRCSF-SLHSGIPGTEGWMAPELLQ-LLPPDS------------ 699
            |.    |.::|||||.|||...:.|. :......|:.||.:||:|. .|...|
pombe   790 LSKTRVRALISDFGLSKKLDFNQSSLRNTTFEAAGSYGWRSPEILSGSLSQQSKEIQVKTREGRI 854

Human   700 --PTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAML 762
              .:.|.|||:.||:|||.|:||.||||.....:.|||.|..||.||:......|:|.||:..|:
pombe   855 RQASHATDIFALGCIFYYTLTGGMHPFGSHYDCEGNILKGNYCLVHLQSLGECGVLAADLIEDMI 919

Human   763 SPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQ--EPLVRALEAGGCAVVRDNWHE 825
            :..|..||:...||.||.||..||:|.|..||||..|.|...  .||::.||....:|:.:||..
pombe   920 AFEPSKRPTIEVVLNHPLFWDYAKKLDFLIDVSDRFEVEERDPPSPLLQMLENNSKSVIGENWTT 984

Human   826 HISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLL 890
            .:...|..:|.|:|.|.|:.:.|:||.:|||:|||::||..||:.||.:||||..||..:||.||
pombe   985 CLHSSLVDNLGKYRKYDGSKILDILRVLRNKRHHYQDLPESVRRVLGDLPDGFTSYFVEKFPMLL 1049

Human   891 LHTHRAMRSCA-SESLFLPY 909
            ||.:..::... .||.|..|
pombe  1050 LHCYHLVKDVLYEESQFKRY 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERN2	NP_150296.4	Luminal_IRE1	38..366	CDD:188875	87/433 (20%)
		PQQ	<41..237	CDD:224437	59/273 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..509		10/44 (23%)
		STKc_IRE1	517..782	CDD:270884	118/292 (40%)
		S_TKc	520..781	CDD:214567	118/288 (41%)
		RNase_Ire1	785..910	CDD:199217	54/128 (42%)
ire1	NP_593384.1	Luminal_IRE1_like	82..440	CDD:276097	84/416 (20%)
		STKc_IRE1	652..939	CDD:270884	117/287 (41%)
		S_TKc	658..938	CDD:214567	117/280 (42%)
		RNase_Ire1	942..1070	CDD:199217	54/128 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	223	1.000	Domainoid score	I603
eggNOG	1	0.900	-	-		E2759_KOG1027
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	368	1.000	Inparanoid score	I512
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001857
OrthoInspector	1	1.000	-	-		otm54035
orthoMCL	1	0.900	-	-		OOG6_102150
Panther	1	1.100	-	-	LDO	PTHR13954
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2163
SonicParanoid	1	1.000	-	-		X1217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.850