Sequence 1: | NP_006436.3 | Gene: | PRPF8 / 10594 | HGNCID: | 17340 | Length: | 2335 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_610735.1 | Gene: | Prp8 / 36304 | FlyBaseID: | FBgn0033688 | Length: | 2396 | Species: | Drosophila melanogaster |
Alignment Length: | 2331 | Identity: | 2134/2331 - (91%) |
---|---|---|---|
Similarity: | 2246/2331 - (96%) | Gaps: | 7/2331 - (0%) |
- Green bases have known domain annotations that are detailed below.
Human 8 RGPG-NPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKEDMPPEHVRKIIR 71
Human 72 DHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVI 136
Human 137 EPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEAIQLELDPEEDA 201
Human 202 PVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLANQLLTDLVDDNYFYLFDLKAFFTS 266
Human 267 KALNMAIPGGPKFEPLVRDINLQDEDWNEFNDINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTW 331
Human 332 YHTPNVVFIKTEDPDLPAFYFDPLINPISHRH-SVKSQEPLPDDDEEFELPEFVEPFLKDTPLYT 395
Human 396 DNTANGIALLWAPRPFNLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALK 460
Human 461 HRPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLK 525
Human 526 PVKTLTTKERKKSRFGNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTG 590
Human 591 MYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNL 655
Human 656 LARQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCW 720
Human 721 KANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLK 785
Human 786 AEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLILALERLKEAY 850
Human 851 SVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLVPVYDVEPLE 915
Human 916 KITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGINNLQDVWETSEGECNVMLESR 980
Human 981 FEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFASFIVQYYG 1045
Human 1046 LVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATEAAHPIRLFCRYIDRIHIFFRFTADEARDLI 1110
Human 1111 QRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFV 1175
Human 1176 SVYSKDNPNLLFNMCGFECRILPKCRTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRF 1240
Human 1241 HNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNS 1305
Human 1306 KMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYR 1370
Human 1371 YIQPWESEFIDSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKG 1435
Human 1436 WRVRTDFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEG 1500
Human 1501 LFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGK 1565
Human 1566 IPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADIL 1630
Human 1631 LFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYARAKFLDYTTDNMSIY 1695
Human 1696 PSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPALYVLRERIRKGLQLYSSEPTE 1760
Human 1761 PYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTS 1825
Human 1826 VWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQ 1890
Human 1891 LPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNNDRAKVILK 1955
Human 1956 PDKTTITEPHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPS 2020
Human 2021 QQRQQIAEIEKQTKEQSQLTATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHL 2085
Human 2086 RTNHIYVSSDDIKETGYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQ 2150
Human 2151 WGTHQTVHLPGQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIIT 2215
Human 2216 CSFTPGSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWN 2280
Human 2281 YNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQE-GEVYSADREDLYA 2335 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
PRPF8 | NP_006436.3 | PRP8 | 1..2335 | CDD:227505 | 2132/2329 (92%) |
Reverse transcriptase homology domain | 812..1303 | 456/490 (93%) | |||
Linker | 1304..1577 | 267/272 (98%) | |||
Important for branch point selection. /evidence=ECO:0000250 | 1513..1526 | 11/12 (92%) | |||
Restriction endonuclease homology domain | 1581..1752 | 160/170 (94%) | |||
Involved in interaction with pre-mRNA 5' splice site | 1669..2034 | 354/364 (97%) | |||
RNase H homology domain | 1767..2020 | 247/252 (98%) | |||
Required for interaction with EFTUD2 and SNRNP200. /evidence=ECO:0000269|PubMed:17317632 | 2301..2335 | 21/34 (62%) | |||
Prp8 | NP_610735.1 | PRP8 | 64..2396 | CDD:227505 | 2132/2329 (92%) |
PRO8NT | 118..268 | CDD:285342 | 134/149 (90%) | ||
PROCN | 456..856 | CDD:285343 | 376/399 (94%) | ||
RRM_4 | 1046..1137 | CDD:287556 | 85/90 (94%) | ||
U5_2-snRNA_bdg | 1270..1402 | CDD:287555 | 127/131 (97%) | ||
U6-snRNA_bdg | 1502..1660 | CDD:287554 | 156/157 (99%) | ||
RNase_H_like_Prp8_IV | 1826..2076 | CDD:260013 | 244/249 (98%) | ||
MPN_PRP8 | 2127..2377 | CDD:163687 | 222/249 (89%) |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 1 | 0.930 | - | - | C165151436 | |
Domainoid | 1 | 1.000 | 815 | 1.000 | Domainoid score | I66 |
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 1 | 1.000 | - | - | ||
Homologene | 1 | 1.000 | - | - | H4706 | |
Inparanoid | 1 | 1.050 | 4456 | 1.000 | Inparanoid score | I4 |
Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S96 |
OMA | 1 | 1.010 | - | - | QHG53611 | |
OrthoDB | 1 | 1.010 | - | - | D156083at2759 | |
OrthoFinder | 1 | 1.000 | - | - | FOG0004087 | |
OrthoInspector | 1 | 1.000 | - | - | oto90010 | |
orthoMCL | 1 | 0.900 | - | - | OOG6_101765 | |
Panther | 1 | 1.100 | - | - | LDO | PTHR11140 |
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R1384 |
SonicParanoid | 1 | 1.000 | - | - | X2835 | |
SwiftOrtho | 1 | 1.000 | - | - | ||
TreeFam | 1 | 0.960 | - | - | ||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
17 | 16.850 |