Protein Alignment POMT1 and PMT4

DIOPT Version :10

• Sequence 1: NP_009102.4
• Gene: POMT1 / 10585
• HGNCID: 9202
• Length: 747
• Species: Homo sapiens
• Sequence 2: NP_012677.1
• Gene: PMT4 / 853608
• SGDID: S000003904
• Length: 762
• Species: Saccharomyces cerevisiae
• Alignment Length: 765
• Identity: 234/765 - (30%)
• Similarity: 374/765 - (48%)
• Gaps: 116/765 - (15%)

Human    22 LTGMGLLSRLWRLTYPRAVVFDEVYYGQYISFYMKQIFFLDDSGPPFGHMVLALGGYLGGFDGNF 86
            :|.:...:|.:::.||:.||||||::|::.|:|:::.:|. |..|||..|::|..|:|.|:||:|
Yeast    59 VTLLAFAARFYKIWYPKEVVFDEVHFGKFASYYLERSYFF-DVHPPFAKMMIAFIGWLCGYDGSF 122

Human    87 LWNRIGAEYSSN-VPVWSLRLLPALAGALSVPMAYQIVLELHFSHCAAMGAALLMLIENALITQS 150
            .::.||..|.:: .|..:.|...|:.|.|:||:.:..:.||:|.......|:||:.|:.|.:|::
Yeast   123 KFDEIGYSYETHPAPYIAYRSFNAILGTLTVPIMFNTLKELNFRAITCAFASLLVAIDTAHVTET 187

Human   151 RLMLLESVLIFFNLLAVLSYLKFFNCQKHSPFSLSWWFWLTLTGVACSCAVGIKYMGVFTYVLVL 215
            ||:||:::||......:..|::|:.||...||:.||:.||..||::.|..:..||:||.||..:.
Yeast   188 RLILLDAILIISIAATMYCYVRFYKCQLRQPFTWSWYIWLHATGLSLSFVISTKYVGVMTYSAIG 252

Human   216 GVAAVHAWHLLGDQTLSNVGADVQCCMRPACMGQMQMSQGVCVFCHLLARAVALLVIPVVLYLLF 280
            ..|.|:.|.||.    ...|..::..||                 |...|...|::||.|:||.:
Yeast   253 FAAVVNLWQLLD----IKAGLSLRQFMR-----------------HFSKRLNGLVLIPFVIYLFW 296

Human   281 FYVHLILVFRSGPHDQIMSSAFQASLEGGLARITQGQPLE-----VAFGSQVTLRNVFGKPVPCW 340
            |:||..::..|||.|..||:.||.:|        :..||.     |.:...:|:::   :....:
Yeast   297 FWVHFTVLNTSGPGDAFMSAEFQETL--------KDSPLSVDSKTVNYFDIITIKH---QDTDAF 350

Human   341 LHSHQDTYPMIYENGRGSSHQQQVTCYPFKDVNNWWIVKDPR-----RHQLVVSSPPRPVRHGDM 400
            ||||...||..||:||.||..||||.|...|.||.|.|..|.     :.|.|:.:     :|
Yeast   351 LHSHLARYPQRYEDGRISSAGQQVTGYTHPDFNNQWEVLPPHGSDVGKGQAVLLN-----QH--- 407

Human   401 VQLVHGMTTRSLNTHDVAAPLSPHSQEVSCYI--DYNISMPAQNLWRLEIVNRGSDTDVWKTILS 463
            ::|.|..|...|..||||:|..|.::|::...  :.:..:..:.|:..:.:.:..:..|.|:...
Yeast   408 IRLRHVATDTYLLAHDVASPFYPTNEEITTVTLEEGDGELYPETLFAFQPLKKSDEGHVLKSKTV 472

Human   464 EVRFVHVNTSAVLKLSGAH----LPDWGYRQLEIVGEKLSRGYHGSTVWNVEEHRYGASQEQRER 524
            ..|..||:||..|   ..|    |||||::|.||.|.|  :....|..|.|:|      ....:.
Yeast   473 SFRLFHVDTSVAL---WTHNDELLPDWGFQQQEINGNK--KVIDPSNNWVVDE------IVNLDE 526

Human   525 ERELHSPAQVDVSRNLSFMARFSELQWRMLALRSD-DSEHKYSSSPLEWVTLDTNIAYWLHPRTS 588
            .|:::.|   .|.:.|.|:.::.|.|..|....:. .|||.::|.|..|....:.:::|.:....
Yeast   527 VRKVYIP---KVVKPLPFLKKWIETQKSMFEHNNKLSSEHPFASEPYSWPGSLSGVSFWTNGDEK 588

Human   589 AQIHLLGNIVIWVSGSLALAIYALLSLWYLLRRRRNVHDLPQDAWLRWVLAGALC--AGGWAVNY 651
            .||:.:|||:.|....::||::..:.:..|:.|.|..:.|  :...|..|.|.|.  ...|..:|
Yeast   589 KQIYFIGNIIGWWFQVISLAVFVGIIVADLITRHRGYYAL--NKMTREKLYGPLMFFFVSWCCHY 651

Human   652 LPFFLMEKTLFLYHYLPALTFQILLLPVVLQHI-SDHLCRS-QLQR------------------- 695
            .|||||.:..||:|||||.....|....:.:.| ||  |:| .|::
Yeast   652 FPFFLMARQKFLHHYLPAHLIACLFSGALWEVIFSD--CKSLDLEKDEDISGASYERNPKVYVKP 714

Human   696 -SIFSALV---VAW---YSSACHVSNTLRPLTYGDKSLSPHELKALRWKD 738
             ::|...|   |||   |.|         ||.|||.||||.|:.:..|.|
Yeast   715 YTVFLVCVSCAVAWFFVYFS---------PLVYGDVSLSPSEVVSREWFD 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POMT1	NP_009102.4	PMT	20..289	CDD:396786	89/267 (33%)
		beta-trefoil_MIR_POMT1	321..515	CDD:467752	63/204 (31%)
		PMT_4TMC	544..738	CDD:465056	65/224 (29%)
PMT4	NP_012677.1	PMT	58..305	CDD:396786	89/267 (33%)
		beta-trefoil_MIR_PMT4-like	334..521	CDD:467756	63/208 (30%)
		PMT_4TMC	543..755	CDD:465056	65/224 (29%)