DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NPC2 and Npc2d

DIOPT Version :9

Sequence 1:	NP_001350617.1	Gene:	NPC2 / 10577	HGNCID:	14537	Length:	174	Species:	Homo sapiens
Sequence 2:	NP_649975.1	Gene:	Npc2d / 41232	FlyBaseID:	FBgn0037782	Length:	173	Species:	Drosophila melanogaster

Alignment Length:	156	Identity:	44/156 - (28%)
Similarity:	68/156 - (43%)	Gaps:	8/156 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     9 LLLALSTAAQAEP-VQFKDCGSVDGVIKEVNVSPCPTQPCQLSKGQSYSVNVTFTSNIQSKSSKA 72
            |||:|:.|.|..| ...|.|........||.|..|.|.|||:.||.:....:.|..:........
  Fly    13 LLLSLAEAQQEHPATSVKKCSGSKPFPLEVRVHNCVTPPCQIVKGTTQKFEIDFAVDKYITQLTT 77

Human    73 VVHGILMG-VPVPFPIPEP-----DGCKSGINCPIQKDKTYSYLNKLPVKSEYPSIKLVVEWQLQ 131
            :|....:| :.||:.:|..     ...:.|..||:...:..|||...|: .|||.|.:.:|..|.
  Fly    78 LVKATTLGIITVPYELPADVAAVCPNLQYGAYCPLYPTEDVSYLFTFPI-GEYPEIGVKIEIYLV 141

Human   132 DDKNQSLFCWEIPVQIVSLSGGERAW 157
            |..|:...|:...:::|..:||...:
  Fly   142 DQDNEIATCFVCDIKVVKGNGGNTVY 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPC2	NP_001350617.1	Npc2_like	24..145	CDD:238458	34/126 (27%)
Npc2d	NP_649975.1	Npc2_like	29..155	CDD:238458	34/126 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4063
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1612792at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11306
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.880