DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CEL and Nlg3

DIOPT Version :9

Sequence 1:	NP_001798.3	Gene:	CEL / 1056	HGNCID:	1848	Length:	753	Species:	Homo sapiens
Sequence 2:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster

Alignment Length:	721	Identity:	188/721 - (26%)
Similarity:	283/721 - (39%)	Gaps:	195/721 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    26 VYTEGGFVEGVNKKL-GLLGDSVDIFKGIPFAAP---TKALENPQPHPGWQGTLKAKNFKKRCLQ 86
            :.|..|.:.||..:| |...|.|:.::|||:|:|   ......|.....|.|..||..|...|.|
  Fly   158 INTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCPQ 222

Human    87 --------ATITQDSTYG---------------DEDCLYLNIWVPQGRKQV-SRD---------- 117
                    ....:....|               .||||||||:||   .|| |||
  Fly   223 RLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVP---IQVGSRDSSGSSSSSSA 284

Human   118 -------------------------------LPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIA 151
                                           .||:::::|.::...||:.        |||..:|
  Fly   285 GSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNP--------YDGSVLA 341

Human   152 TRGNVIVVTFNYRVGPLGFLSTGD---ANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGE 213
            :.|.::|||.|||:|.||||:...   :.||.||||.|...|:.|:|.||||||||||:|||.|.
  Fly   342 SYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGH 406

Human   214 SAGGASVS--LQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDA--ARM 274
            ..|.|.|.  :.:::.....|..|||..||..|:||.:..||..:|..||..|.| ..|.  |.:
  Fly   407 GTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNC-ASDLPHAHL 470

Human   275 AQCLKVTDPRALTLAYKVPLAGLEYPMLHYVGFVPVID------GDFIPADPINLYANAADIDYI 333
            .:||:   .:.|.....||:...|:..    .|.|.||      ||::|..|.:..|.|......
  Fly   471 MKCLR---EKTLDQLLSVPIRPPEFGF----AFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQAST 528

Human   334 AGTNNMDGH--IFAS--------------IDMPAINKGNK-----KVTEEDFYKLVSEFTITKGL 377
            |..|.:.|.  |.|:              :...||||.::     .||..:.:...:...:..|:
  Fly   529 AAGNGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSGDVQYGI 593

Human   378 RGAK----------------------TTFDVYTESWAQDPSQE--NKKKTVVDFETDVLFLVPTE 418
            ...:                      |..:.||: | :.|.|.  |.:...::..:|...:.|..
  Fly   594 EADRRSRILKAYVRNTYTFHLNEIFATIVNEYTD-W-ERPVQHPINIRDETLEALSDAQVVAPAA 656

Human   419 IALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFA-----TPTGYRPQDR 478
            ..:..|.|:.::  :|.|:|.:.:|...||:..|..|.:|:.|:||.|..     ....|...:.
  Fly   657 QTVDLHSADHRN--SYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEI 719

Human   479 TVSKAMIAYWTNFAKTGDPNMGDSAVPTH-------------WEPYTTENSGYLEITKKMGSSSM 530
            ::|:.::.||:||.:||:||  :.....|             |..|.:.:..||....|   ..:
  Fly   720 SLSEVVMFYWSNFVRTGNPN--EQMETEHGSRQERSRYKTIEWTAYESVHKKYLNFDTK---PKL 779

Human   531 KRSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPT------GDSETAPVPPTGDSG 589
            |...|.:.|.:|      |..:.|..    .|.||:    ||..      .|.|...:|  .|:.
  Fly   780 KNHYRAHRLSFW------LNLIPDLH----KPGGDN----VPAAHHQLHDDDDEDNNIP--SDAS 828

Human   590 APPVPP 595
            ..|:.|
  Fly   829 VKPLNP 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CEL	NP_001798.3	Heparin-binding	21..121		38/163 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..753		11/47 (23%)
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745		11/43 (26%)
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	174/660 (26%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	45/104 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910