DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CEL and Nrt

DIOPT Version :9

Sequence 1:	NP_001798.3	Gene:	CEL / 1056	HGNCID:	1848	Length:	753	Species:	Homo sapiens
Sequence 2:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	141/555 - (25%)
Similarity:	202/555 - (36%)	Gaps:	179/555 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    31 GFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPG---------WQGTLKAKNFKKRCLQ 86
            |.||||.:      |....|:|||:|.|  .::..:..|.         |..||:..|....|.|
  Fly   368 GPVEGVKE------DGAFAFRGIPYAKP--PVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQ 424

Human    87 ATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIA 151
             .:...:|.||||||||::..|..|  .:..|||::.| |...|.|...|      .|......:
  Fly   425 -RLGNGTTVGDEDCLYLDVVTPHVR--YNNPLPVVVLI-GAESLAGPSPG------ILRPSARYS 479

Human   152 TRGNVIVVTFNYRVGPLGFLS----TGDANLP--GNYGLRDQHMAIAWVKRNIAAFGGDPNNITL 210
            ...:||.|..|:|:|..|||:    |.:|:.|  |||.|.|....:.|:|.||..|||||.::||
  Fly   480 RSHDVIFVRPNFRLGVFGFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTL 544

Human   211 FGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMA 275
            .|..||...|:|...|...|||..||.:.||.|:.|    ..||..:.|..|::...:..|.  .
  Fly   545 LGHRAGATLVTLLVNSQKVKGLYTRAWASSGSAILP----GKPLSESGKQNEQLMATLECAD--I 603

Human   276 QCLKVTDPRALTLAYKVPLAGLEYPMLHYVGFVP---------------VIDGDFIPADPINLY- 324
            |||:......|..|  .|...|.:|:     .:|               |:|||.:...|.:.:
  Fly   604 QCLREASSERLWAA--TPDTWLHFPV-----DLPQPQEANASGSRHEWLVLDGDVVFEHPSDTWK 661

Human   325 ---ANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGLRGAKTTFDV 386
               ||                     |.|.:..|                         .|..:.
  Fly   662 REQAN---------------------DKPVLVMG-------------------------ATAHEA 680

Human   387 YTE-------SWAQDPSQ---ENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFS-- 439
            :||       :|.::..:   ||.:...:....:|:           .:.||.|   ||.|.|
  Fly   681 HTEKLRELHANWTREEVRAYLENSQIGALGLTDEVI-----------EKYNASS---YASLVSII 731

Human   440 -----------HPSRMPVYPKWV-----GADHA----DDIQYVFGKPFATPTGYRP----QDRTV 480
                       :..:.|..|.:|     |.|..    .|:|.:.|:       |.|    |.|.|
  Fly   732 SDIRSVCPLLTNARQQPSVPFYVVTQGEGPDQLATVDADVQAILGR-------YEPHTVEQRRFV 789

Human   481 SKAMIAYWTNFAKTGDP----------NMGDSAVP 505
            | ||...:..:...|..          |:|..|.|
  Fly   790 S-AMQQLFYYYVSHGTVQSFVQNRRVINVGQDAQP 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CEL	NP_001798.3	Heparin-binding	21..121		32/98 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..753
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	141/555 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900