Protein Alignment SPTLC1 and lcb1

DIOPT Version :10

• Sequence 1: NP_001268232.1
• Gene: SPTLC1 / 10558
• HGNCID: 11277
• Length: 513
• Species: Homo sapiens
• Sequence 2: NP_595848.1
• Gene: lcb1 / 2540820
• PomBaseID: SPBC18E5.02C
• Length: 509
• Species: Schizosaccharomyces pombe
• Alignment Length: 461
• Identity: 177/461 - (38%)
• Similarity: 266/461 - (57%)
• Gaps: 33/461 - (7%)

Human     9 VLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS--------DLTVKEKEELIEEWQ 65
            ::...:::.|:.......:|.:|      |:|:..|.|::..        :.|.||..||:::|:
pombe    34 IVKRYIKSSYQNDPLRTFIEFLL------LVFAAYYVLRKPRTSPDNNYVEFTEKEINELVDDWK 92

Human    66 PEPLVPPVP-------KDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALA 123
            |||||..:.       |..|     ::.....|..:::|:...||||||||.|.:|..:...|:|
pombe    93 PEPLVAELTDVEKLELKSIP-----VLESVHLHTKLIDGRPITNFASFNFLDLAENKHITECAVA 152

Human   124 SLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFVD 188
            :|::.|:|.|||.|||||.|.||.||..:|.|:..|.||:|:..|.||:|.|||:||||||:.||
pombe   153 TLRECGLGACGPPGFYGTQDKHLRLEKDIASFIGVERAIVYAQSFQTISSVIPAFSKRGDILVVD 217

Human   189 RAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGT 253
            .|..||||||:|.||:.|:.||||:|.||||:|  ||:||........:|||||:.||:..|.|.
pombe   218 EACNFAIQKGIQISRTTIRYFKHNNMKDLERIL--QELEDDFVKHNRPLTRRFIITEGISENYGD 280

Human   254 ICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIGGFC 318
            :..|.::|.||.|||.|:.|:|:.|||..|..|:|:|||:|:...|:::|..::..:||..||||
pombe   281 MVDLTKIVALKKKYKYRLILDETWSFGTCGRTGKGLTEHFGVPPTDVEIIIGSLTTSLAGGGGFC 345

Human   319 CGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPG-IFAVLKEKCGQIHKALQGISG 382
            .|...:::||||||..|.:||:||..||.||.||::|:..:.| :...|:.|....|..|.....
pombe   346 AGSELMVEHQRLSGMAYIYSAALPASLAVAAYEAISILSRDGGSMLNDLRSKSALFHAKLSRNKF 410

Human   383 LKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVDQCMNRSIALTQARYLEKEEKCLPPPRGR-- 445
            .:...:..||..||:.::...|.::.|.||:|||:.|:.....:.:|:.:|..|:....|..|
pombe   411 FETSSDIESPIIHLRFKDKDISHDKQVFLLEEIVELCIAEGFLIARAKRVESLERVKVQPSLRIC 475

Human   446 --TGES 449
              ||.|
pombe   476 ISTGHS 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPTLC1	NP_001268232.1	Interaction with SPTLC2. /evidence=ECO:0000269|PubMed:33558762	1..66		13/64 (20%)
		AAT_I	11..442	CDD:450240	172/446 (39%)
lcb1	NP_595848.1	AAT_I	51..493	CDD:450240	176/444 (40%)