DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mbnl2 and mbl

DIOPT Version :9

Sequence 1:	NP_001347306.1	Gene:	Mbnl2 / 105559	MGIID:	2145597	Length:	385	Species:	Mus musculus
Sequence 2:	NP_001261046.1	Gene:	mbl / 36945	FlyBaseID:	FBgn0265487	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	446	Identity:	165/446 - (36%)
Similarity:	221/446 - (49%)	Gaps:	111/446 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 RDTKWLTLEVCRQYQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCSREN--CKYLHP 71
            :|::||.|||||::||..|||.|.||||||||.:.:|:||:|.||:||:||||:|:.  |||.||
  Fly    14 KDSRWLQLEVCREFQRNKCSRQDTECKFAHPPANVEVQNGKVTACYDSIKGRCNRDKPPCKYFHP 78

Mouse    72 PTHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMFPGTPL--HPVPTFPVGPTIGTNAAISFAPY- 133
            |.|||.||.|||||:|..:..    |.|||. :.||.|:  ..||.....|.:....|.|::||
  Fly    79 PQHLKDQLLINGRNHLALKNA----LMQQMG-IAPGQPVISGQVPAVATNPYLTGIPANSYSPYY 138

Mouse   134 ----LAPVTPGVGLVPTEVLPTTPVIVPGSPPVTVPGSTATQKLLRTDKLEVCREFQRGNCARGE 194
                |.|...|...|.:::.|..|..|          ..|.||:.|:|:|||||||.||.|.|.|
  Fly   139 TTGHLVPALLGPDPVTSQLGPVVPQTV----------QVAQQKIPRSDRLEVCREFLRGACKRAE 193

Mouse   195 TDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQ 259
            ::||||||.:| :...:|.::|||||.:||||.|:.|:|||||.||||::||||.:|  .||||.
  Fly   194 SECRFAHPQES-VARHDDGSITVCMDAVKGRCARDPCRYFHPPLHLQAQLKAAQTRA--TAVAAA 255

Mouse   260 AAAAAATVMTQSTAKALKRPLEATVDLAFPP---------GALH----------PLPKRQALEKS 305
            ||....|:.               ..:.|.|         |:.:          |. ||.|.|||
  Fly   256 AAVWLYTIY---------------FSILFEPSLCMDVKTVGSFYYDNFQFSGMVPF-KRPAAEKS 304

Mouse   306 NGASTVFNPSVLHYQQAL-------------------TSAQLQQH-------TAFIPTGSVLCMT 344
              ...|:.|....|||.:                   ...|.|||       ...:...||:..|
  Fly   305 --GIPVYQPGATAYQQLMQPYVPVSCEYPQQQQQPPPQQQQQQQHQQQNVLLQQQLQLSSVITTT 367

Mouse   345 PATS---------------IVPMMHSATSATVSAATTPATSV------PFAATATA 379
            ..|:               |:..:.::|:.|.||.||.::|:      |...|.||
  Fly   368 STTATASNNMINNNINNKGIINAVMASTNITSSATTTASSSLLSALGTPPTTTTTA 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mbnl2	NP_001347306.1	ZnF_C3H1	17..40	CDD:214632	16/22 (73%)
Mbnl2	NP_001347306.1	ZnF_C3H1	178..202	CDD:214632	16/23 (70%)
mbl	NP_001261046.1	ZnF_C3H1	175..201	CDD:214632	17/25 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837607
Domainoid	1	1.000	149	1.000	Domainoid score	I4407
eggNOG	1	0.900	-	-		E1_KOG2494
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	155	1.000	Inparanoid score	I4290
Isobase	1	0.950	-	0	Normalized mean entropy	S5175
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001679
OrthoInspector	1	1.000	-	-		otm42996
orthoMCL	1	0.900	-	-		OOG6_109473
Panther	1	1.100	-	-	LDO	PTHR12675
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2627
SonicParanoid	1	1.000	-	-		X1238
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.730