Protein Alignment DCTN2 and DCTN2-p50

DIOPT Version :9

• Sequence 1: NP_001334994.1
• Gene: DCTN2 / 10540
• HGNCID: 2712
• Length: 446
• Species: Homo sapiens
• Sequence 2: NP_524690.1
• Gene: DCTN2-p50 / 44086
• FlyBaseID: FBgn0021825
• Length: 380
• Species: Drosophila melanogaster
• Alignment Length: 412
• Identity: 126/412 - (30%)
• Similarity: 210/412 - (50%)
• Gaps: 47/412 - (11%)

Human    35 PHSHDNPGVYLPFVLPCLLLKARNEPDVYETSDLPEDDQAEFDAELEELTSTSVEHIIVNPNAAY 99
            |...:.||:            |.::||||||.|.||.|.:::..  ||..:.::|.:.::|:.|:
  Fly     4 PKFQNLPGI------------AYDQPDVYETPDDPELDTSDYYE--EEPENEAIERLHISPSVAH 54

Human   100 DKFKDKRVGTKGLDFSDRIGKTKRTGYE---SGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTE 161
            .:|....| ...:||:||||:....||:   |.:||::|:  |.||||.||.|||..|:.||..|
  Fly    55 KRFSGATV-EGSVDFTDRIGRRMCRGYDTRGSSDYELVGQ--GEKETPVQKCQRLQIEMNELLNE 116

Human   162 VEKIKTTVKESATEEKLTPVLLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQL 226
            |..::.. ::.|.|||.:...:|..::..::.|.:..||::||.:..     |.....|.|:.|:
  Fly   117 VAALQVD-RKVADEEKQSYDAVATVISTARKVLESLKLEQVLGKEQT-----PGSKQVKALISQV 175

Human   227 EATKNSKGGSGGKTTGTP-PDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELETAVRCDQDAQ 290
            |..|.|     |..|..| |.:.|              :..|:||.||:|:::||..:....|..
  Fly   176 EEFKQS-----GVLTAIPTPGTDL--------------AATARVASLEQRISQLEKVLGAQPDKL 221

Human   291 NPLSAGLQGACLMETVELLQAKVSALDLAVLDQVEARLQSVLGKVNEIA-KHKASVEDADTQSKV 354
            :.|:|......::|.|..|..|.:.:....||.:|.||.|:.||::.|| |...|.:||....|:
  Fly   222 SRLTAATNTTNVLEAVRHLSTKAALIQPDKLDTIEQRLTSLAGKMDAIAEKSSGSAQDAKRDQKI 286

Human   355 HQLYETIQRWSPIASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIANSLKDNTTLLTQV 419
            .:||:..:|..|:...||.:::|:..::.||:.|..|.:::..::..|..|..||.:|..||..|
  Fly   287 TELYDIAKRTEPVVEILPHVIERMQALEALHKYANNFAKIIAEIEQKQGTITTSLVNNKELLHSV 351

Human   420 QTTMRENLATVEGNFASIDERM 441
            |.|..:||.|:....|.:::|:
  Fly   352 QETFAQNLETINSKVAKVEQRV 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCTN2	NP_001334994.1	Dynamitin	59..444	CDD:309856	122/388 (31%)
DCTN2-p50	NP_524690.1	Dynamitin	16..376	CDD:282730	122/388 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159613
Domainoid	1	1.000	183	1.000	Domainoid score	I3452
eggNOG	1	0.900	-	-		E1_KOG3958
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4667
Inparanoid	1	1.050	204	1.000	Inparanoid score	I3746
Isobase	1	0.950	-	0	Normalized mean entropy	S5879
OMA	1	1.010	-	-		QHG55390
OrthoDB	1	1.010	-	-		D421732at33208
OrthoFinder	1	1.000	-	-		FOG0007427
OrthoInspector	1	1.000	-	-		oto91094
orthoMCL	1	0.900	-	-		OOG6_103885
Panther	1	1.100	-	-	LDO	PTHR15346
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2476
SonicParanoid	1	1.000	-	-		X6311
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750