DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATG7 and Atg7

DIOPT Version :9

Sequence 1:	XP_006712994.1	Gene:	ATG7 / 10533	HGNCID:	16935	Length:	738	Species:	Homo sapiens
Sequence 2:	NP_611350.1	Gene:	Atg7 / 37141	FlyBaseID:	FBgn0034366	Length:	684	Species:	Drosophila melanogaster

Alignment Length:	708	Identity:	292/708 - (41%)
Similarity:	411/708 - (58%)	Gaps:	94/708 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    13 LQFAPFSSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLPARLTLEFSAFDMSAPTP 77
            |||||:.|.:...|||:|.:.||:..||.::.:.|.|:|.|.:::|  ..|.::::|::..|..|
  Fly     9 LQFAPWESFVSPTFWHKLAELKLDHDRLSDSKRSITGHYTNRNASG--CLLEVDYTAYNRMAKPP 71

Human    78 ARCCPAIGTLYNTNTLESFKTADKKLLLEQAANEIWESIKSGTALENPVLLNKFLLLTFADLKKY 142
            .....||||:||.||:|.||..||..||.....|:...:.||.||.:|.||.:|.:|:|||||.:
  Fly    72 KFSHSAIGTIYNKNTIEEFKALDKLQLLADEGKELLADMCSGGALRDPSLLTRFFVLSFADLKCH 136

Human   143 HFYYWFCYPALCLPESLPLIQGPVG--LDQRFSLKQIEALECAYDNLCQTEGVTALP----YFLI 201
            .:||||.:|....| :|.| ||.|.  .|...|...|.||:             |||    .|.|
  Fly   137 SYYYWFAFPCPLTP-TLKL-QGAVQKLRDLPNSSSYIMALK-------------ALPTESQNFFI 186

Human   202 KY---DENMVLVSLLKHYSD------FFQGQRTKITIGVYDPCNLAQYPGWPLRNFLVLAAHRWS 257
            .|   ::|:.....|....|      :|         |..||... ::|.|.:||:
  Fly   187 LYANVEKNIFEARSLSSLDDKNVEFCYF---------GFADPSEY-EHPAWIMRNY--------- 232

Human   258 SSFQSVEVVCFRDRTMQ--GAR-----DVAHSIIFEVKLPEMAFSPDCP-------KAVGWEKNQ 308
            ::|...:...|..:.::  |.|     ::..|::::|...|.     |.       |.||||.|:
  Fly   233 AAFLLQQCPSFVGKPLKFLGLRHNQQMNIDDSLVWKVIQTEA-----CDLSQSENIKFVGWELNK 292

Human   309 KGGMGPRMVNLSECMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVART 373
            .|.||||||.:.:.|||.:|||:||:||||||.|||||.|:|:.:...||||.|||||||.|||.
  Fly   293 NGKMGPRMVCMRDSMDPAKLAENSVNLNLKLMKWRLVPDLNLEIISQTKCLLFGAGTLGCAVARN 357

Human   374 LMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADRLQKIFPGVNARGFNMSIP 438
            |:.||.:|||.:|:.|:.:||||||.||...|.:.|.:.||..||.||::|.|.....|:.:.||
  Fly   358 LLSWGFKHITLLDSGKVGFSNPVRQNLYTHADAVAGNRMKATTAAQRLKEINPSAETAGYVLEIP 422

Human   439 MPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRESRWLPAVIAASKRKLVINAALGFD 503
            ||||.:..|  .|.|.:..::.:|:|::.|||:|||.|:|||||||.::.|:|.|:|||||||||
  Fly   423 MPGHTIGES--LLAQTKEHLKVIEKLVQDHDVIFLLTDSRESRWLPTLLGAAKEKIVINAALGFD 485

Human   504 TFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTL 568
            :::|||||..:.:   |||       ...::.|...   |.|.:|||||||||.|||:|.:||||
  Fly   486 SYLVMRHGTTRKE---AGD-------DGQEIEGLKC---INGDQLGCYFCNDVTAPGNSLKDRTL 537

Human   569 DQQCTVSRPGLAVIAGALAVELMVSVLQHPEGGYA---IASSSDDRMNE-----PPTSLGLVPHQ 625
            ||||||:|||::.||.:.||||:|::||||....|   .|.|...|..|     |...||::||.
  Fly   538 DQQCTVTRPGVSNIAASYAVELLVALLQHPRKELAPAYYAQSGRGRSEETEEKVPEGLLGILPHS 602

Human   626 IRGFLSRFDNVLPVSLAFDKCTACSSKVLDQYEREGFNFLAKVFNSSHSFLEDLTGLT 683
            |||.|..::|:||.:..|.:|.|||:.||::|::||..||.|.|.:: .|||||||::
  Fly   603 IRGMLCNYENILPATQKFAQCIACSAAVLNEYKKEGHAFLFKTFETA-KFLEDLTGIS 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATG7	XP_006712994.1	ATG7_N	13..321	CDD:293029	107/336 (32%)
		E1_like_apg7	15..693	CDD:273590	290/706 (41%)
		Apg7	357..682	CDD:238763	163/332 (49%)
Atg7	NP_611350.1	ATG7_N	9..303	CDD:293029	107/334 (32%)
		E1_like_apg7	11..682	CDD:273590	290/706 (41%)
		Apg7	341..658	CDD:238763	163/332 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160005
Domainoid	1	1.000	255	1.000	Domainoid score	I2056
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4662
Inparanoid	1	1.050	484	1.000	Inparanoid score	I1461
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55251
OrthoDB	1	1.010	-	-		D393958at33208
OrthoFinder	1	1.000	-	-		FOG0005140
OrthoInspector	1	1.000	-	-		oto90809
orthoMCL	1	0.900	-	-		OOG6_102679
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R111
SonicParanoid	1	1.000	-	-		X3660
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800