Protein Alignment HYOU1 and Hsc70-5

DIOPT Version :9

• Sequence 1: XP_005271449.1
• Gene: HYOU1 / 10525
• HGNCID: 16931
• Length: 1000
• Species: Homo sapiens
• Sequence 2: NP_001286414.1
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 772
• Identity: 192/772 - (24%)
• Similarity: 329/772 - (42%)
• Gaps: 176/772 - (22%)

Human    34 AVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTL-KENERFFGDSAASMAIKNPKATL 97
            ||:.:|||:.:..:|::: |...:::.|.|..|.||..|.. |:.||..|..|...|:.|...|.
  Fly    53 AVIGIDLGTTNSCLAVME-GKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTF 116

Human    98 RYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQI------------SSQLQFSPEEVL 150
            ...:.|:|::.|:|.|        :.::|      .:.:::            :....:||.::.
  Fly   117 YATKRLIGRRFDDPEV--------KKDIT------NLSYKVVKASNGDAWVSSTDGKVYSPSQIG 167

Human   151 GMVLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGV 215
            ..:|...:..||.:...|:|:||:|||.:||.::|:|...|.::|||.||::||:.||.||:||:
  Fly   168 AFILMKMKETAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGM 232

Human   216 FRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLR 280
            .:.:|     :.|..||:|.|:...:|:..|         :...:::....|..|||.:.:..:.
  Fly   233 DKTED-----KIIAVYDLGGGTFDISILEIQ---------KGVFEVKSTNGDTLLGGEDFDNHIV 283

Human   281 ERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDV----DFKA 341
            ..|...|    |.....|:|::..||.:|...|.:.|..||::......:..|..|.    ....
  Fly   284 NFLVAEF----KKDSGIDIRKDNIAMQRLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNL 344

Human   342 KVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELG 406
            |:||.:.|.|..||.:|...|.|:||..||:|..||.:|:||||.||:|:||..:.:..|::. .
  Fly   345 KLTRSKLESLVGDLIKRTIQPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQP-S 408

Human   407 KNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPILVE-----FTREVEEEPGIHSLKHNK 466
            :::|.|||.|:||..|...|  |..|...::.|.....:.:|     |||
  Fly   409 RSVNPDEAVAVGAAVQGGVL--AGDVTDVLLLDVTPLSLGIETLGGVFTR--------------- 456

Human   467 RVLFSRMGPYPQRKVITFNRYSH---DFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSF 528
              |.||....|.:|...|:..|.   .....::.|:...  ..|.::.||..|.     |:..:.
  Fly   457 --LISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREM--ANDNKLLGSFTLV-----GIPPAP 512

Human   529 KKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDA 593
            :..|.     |:..|::|.:|:             |..||:::.|..:....|.|  .||.:.|.
  Fly   513 RGVPQ-----IEVVFDIDANGI-------------VHVSAKDKGTGKEQQIVIQS--SGGLSKDE 557

Human   594 KENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENG 658
            .||...  :.||.:.|:..|   .|.:|:..:.|:.|.|
  Fly   558 IENMIK--KAEEYATADKQK---RELIEIVNQGESIVHD-------------------------- 591

Human   659 DKSEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKL 723
              :|.:....|::      .||.|.||.:|.               :.||..|           |
  Fly   592 --TETKMEEFKSQ------LPAEECEKLKKE---------------IADLRTL-----------L 622

Human   724 QDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAAST 780
            .:....|||  |..||.:||:    ::..||::..|:::|.|.:....:|...::|:
  Fly   623 ANKETADLE--EVRKATSSLQ----QSSLKLFELAYKKMSAERESNAGAGSSDSSSS 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HYOU1	XP_005271449.1	HSP70	35..672	CDD:278441	166/661 (25%)
		NBD_sugar-kinase_HSP70_actin	36..424	CDD:302596	117/404 (29%)
		PHA00666	601..>739	CDD:222808	25/137 (18%)
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	190/763 (25%)
		HSPA9-like_NBD	51..428	CDD:212683	119/408 (29%)
		Syntaphilin	<566..>642	CDD:291936	29/144 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900