DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HYOU1 and CG2918

DIOPT Version :9

Sequence 1:	XP_005271449.1	Gene:	HYOU1 / 10525	HGNCID:	16931	Length:	1000	Species:	Homo sapiens
Sequence 2:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster

Alignment Length:	979	Identity:	421/979 - (43%)
Similarity:	579/979 - (59%)	Gaps:	78/979 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    18 LVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFG 82
            |::.|||. :|||...||||||||||.|||.:|.|||||||.||:||:||||.|:..::..|..|
  Fly     6 LLSALLAG-IALSQGAAVMSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIG 69

Human    83 DSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQLQFSPE 147
            :.|.::.||:|.:...|...||||..|||.|.||:.|||.:.:..||:|.||.|:.|...:||.|
  Fly    70 EDAQTIGIKDPNSAYGYLLDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDEFSVE 134

Human   148 EVLGMVLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALS 212
            |::..:|..::..|::..:|||.:.|:|||.:|.||||.|:|.||::|.|||||||||..|.||:
  Fly   135 ELVAQLLVKAKQFAQESVQQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALN 199

Human   213 YGVFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEA-GMQPQLQIRGVGFDRTLGGLEME 276
            ||||.|.:||.|||..:|||||:..|...:|:||:||.|:. .:.|.:|:.|||:||||||||::
  Fly   200 YGVFHRGEINETAQYFLFYDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQ 264

Human   277 LRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKA 341
            ||||:.||..||..:|.:  .||..:|||:|||.:||.|||.|||||.:..||||.|::|:|||.
  Fly   265 LRLRDYLAQEFNALKKTK--TDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKL 327

Human   342 KVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELG 406
            .|||.:.|:||.||:.|...|:::||.|:.:|||.|.||||.||.||||||||. :|||.|:|||
  Fly   328 PVTREKLEQLCEDLWPRATKPLEEALASSHLSLDVINQVILFGGGTRVPRVQET-IKAVIKQELG 391

Human   407 KNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGI-HSLKHNKRVLF 470
            ||:||||:|.|||||:||.||..||||.|||:||.::|:.|.|    |.:||. .::|..||.||
  Fly   392 KNLNADESATMGAVYKAADLSAGFKVKKFVVKDATLFPLQVSF----ERDPGDGAAVKQVKRALF 452

Human   471 SRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPD-- 533
            :.|.||||:||||||:::.||.|::||.||.....|::...||.|:|.|:||.|.:..:|...
  Fly   453 ALMNPYPQKKVITFNKHTDDFEFYVNYADLDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKEL 517

Human   534 YESKGIKAHFNLDESGVLSLDRVESVFE-TLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENG 597
            .::|||||:|.||:||:.....||.|:| ...||.|:|:|||:|.|:|:|.||    |.:.:|..
  Fly   518 VDNKGIKAYFYLDDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLF----TKEGEEKK 578

Human   598 TDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSE 662
            .::.|||    |..:.:||.:                           :.:.|||.|:   |.|:
  Fly   579 DNSEQEE----AANAGEEPSK---------------------------SEDNEKAKEE---DASK 609

Human   663 AQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLT 727
            .||..|..:...|.     :.|..:....|..:..|...:.||    .|......|||.||..:.
  Fly   610 EQKSEESTKQDTEA-----KNETIKLVTVKSPVTYESQTQFVV----PLVGSAYDQSVAKLAAIN 665

Human   728 LRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTV 792
            ..:.::...|.|.|:|||.|.|.|.||.:..|.:.:|.|::|::..:.|....||.::.......
  Fly   666 KAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYEDLEDPKAE 730

Human   793 MLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGARLI-----PEMDQIFTEV 852
            :.:||||:|:||......|..|.::.||.:.||..:::.:..||...|.:     ||.| :||:|
  Fly   731 IYEEKLAQLKKLSNVFLARHWEHEERPEAIKALKGMIDGAEKFLVTGRNLTKDTNPEKD-VFTQV 794

Human   853 EMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNKAKFTKPRPR 917
            |:.||:|||.||.||.....|.|.||.......|..|||..||..|||||:||:||.|..||:.:
  Fly   795 EIDTLDKVITETNAWLKTETAAQKKLAKNADIRLTVKDITDKMSLLDREVKYLVNKIKIWKPKVK 859

Human   918 PKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDAEPISE-PEKVETAGSEPGDTEPLELGGPGAE 981
            |..:...:.|..:.||.|....|       :||||...| ..|.|....||.|    |:....||
  Fly   860 PAAEKEKKKEEEVVASGSGDDTK-------SEDAEQQQEQATKEEQQEQEPVD----EITPTPAE 913

Human   982 PEQK 985
            .|.|
  Fly   914 EETK 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HYOU1	XP_005271449.1	HSP70	35..672	CDD:278441	308/641 (48%)
		NBD_sugar-kinase_HSP70_actin	36..424	CDD:302596	211/388 (54%)
		PHA00666	601..>739	CDD:222808	28/137 (20%)
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	309/652 (47%)
		HYOU1-like_NBD	23..409	CDD:212672	211/388 (54%)
		TAF4	<572..>627	CDD:296797	17/93 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142503
Domainoid	1	1.000	544	1.000	Domainoid score	I260
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4658
Inparanoid	1	1.050	669	1.000	Inparanoid score	I747
Isobase	1	0.950	-	0	Normalized mean entropy	S2181
OMA	1	1.010	-	-		QHG54551
OrthoDB	1	1.010	-	-		D125779at33208
OrthoFinder	1	1.000	-	-		FOG0003505
OrthoInspector	1	1.000	-	-		oto88844
orthoMCL	1	0.900	-	-		OOG6_101811
Panther	1	1.100	-	-	LDO	PTHR45639
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3997
SonicParanoid	1	1.000	-	-		X2877
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	16	15.790