DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KAT5 and CG1894

DIOPT Version :9

Sequence 1:	NP_874369.1	Gene:	KAT5 / 10524	HGNCID:	5275	Length:	546	Species:	Homo sapiens
Sequence 2:	NP_651620.1	Gene:	CG1894 / 43378	FlyBaseID:	FBgn0039585	Length:	421	Species:	Drosophila melanogaster

Alignment Length:	436	Identity:	147/436 - (33%)
Similarity:	212/436 - (48%)	Gaps:	68/436 - (15%)

- Green bases have known domain annotations that are detailed below.

Human   119 SRPGSPEREVPASAQ--ASGKTLPIPVQITLRFNLPKEREAIPG-GEP-------DQPLSSSSCL 173
            :|.|...:..|...|  .|.|...||  ..|:....||..|..| |:.       ...|.:.|.|
  Fly     5 NRSGDHLKYQPLGDQDGISSKLPDIP--RALQLTNAKESSATRGLGQSASKSEMGKSQLQNDSSL 67

Human   174 QPNHRSTKRKVEVVSPATPVPSETAPASVFPQNGAARRAVAAQPGRK----RKSNCLG------- 227
            |.|.:.||               |...|..    .|:| :.|.|.::    ::.|.:.
  Fly    68 QKNIQETK---------------TITGSCI----EAQR-IGATPKKQLEGVKEPNMISLLHTNAS 112

Human   228 ---TDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTT 289
               .|...|::.|...|.       |.....|..|..::|||.::.||:.::....||||.....
  Fly   113 SNVDDRQRQETIDNEKSD-------VQKEKEDAKVKVIRNIEKVQFGRYEIETTSSSPYPVINDK 170

Human   290 LPVLYLCEFCLKYGRSLKCLQR----HLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLC 350
            ...:|:|||||||    .||::    ||..|..|.|||:.:|||..|..:|:||.|.:.|.|.||
  Fly   171 ATTIYVCEFCLKY----MCLRKSYSYHLYDCKKRCPPGSLLYRKDNIYIYEVDGHKEQLYCQCLC 231

Human   351 LLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYG 415
            |::|.||::|.:.|.:..||||::...|..|.|..|||::|| :..:.|:.|||.||||.|:|||
  Fly   232 LMSKLFLENKKILYSSSSFLFYILCLKDKDGEHFAGYFAREK-TMLNINLNCILVLPPYMRKGYG 295

Human   416 KLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEI 480
            ||||:.|||:|:.|...|.|:||||.:..|.|.|||...:|.:|....|..    .:||.|:|:.
  Fly   296 KLLIDLSYEISRREACIGGPKKPLSKVARLCYLSYWGHILLNLLRHHSSPD----LVTIEELSKA 356

Human   481 TSIKKEDVISTLQYLNLINYYKGQYIL--TLSEDIVDGHERAMLKR 524
            |..::||:||||:::.:..|||..:|:  |.|..|.|....|..|:
  Fly   357 TGFREEDIISTLEFMGMTKYYKVDHIMFYTTSSIIEDRRGLAQFKK 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KAT5	NP_874369.1	Tudor-knot	40..98	CDD:371690
KAT5	NP_874369.1	PLN00104	76..537	CDD:215056	147/436 (34%)
CG1894	NP_651620.1	NAT_SF	130..395	CDD:302625	113/280 (40%)
CG1894	NP_651620.1	MOZ_SAS	202..378	CDD:280097	80/180 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820