Protein Alignment DDX17 and Rm62

DIOPT Version :10

• Sequence 1: NP_001091974.1
• Gene: DDX17 / 10521
• HGNCID: 2740
• Length: 731
• Species: Homo sapiens
• Sequence 2: NP_524243.2
• Gene: Rm62 / 40739
• FlyBaseID: FBgn0003261
• Length: 719
• Species: Drosophila melanogaster
• Alignment Length: 558
• Identity: 320/558 - (57%)
• Similarity: 384/558 - (68%)
• Gaps: 46/558 - (8%)

Human    82 GGGFGD----------RDRDRDRGG---FGARGGGGLPPKKFGNPG--ERLRKKKWDLSELPKFE 131
            |||.||          :.|| ||||   ||  ||||...::.|..|  :.|..:..|.|.|..|:
  Fly   182 GGGGGDYHGIRNGRVEKRRD-DRGGGNRFG--GGGGFGDRRGGGGGGSQDLPMRPVDFSNLAPFK 243

Human   132 KNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFPQYVMDVLMDQHFTEPTP 196
            ||||.|||.||..:||||...|.::||||||  ..|.|:..|...:.|.|||..:..|.:..||.
  Fly   244 KNFYQEHPNVANRSPYEVQRYREEQEITVRG--QVPNPIQDFSEVHLPDYVMKEIRRQGYKAPTA 306

Human   197 IQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQ 261
            ||.||:|:|:||.:.||||:|||||||.|:||||||||:|..|:||||||.||||||||||||:|
  Fly   307 IQAQGWPIAMSGSNFVGIAKTGSGKTLGYILPAIVHINNQQPLQRGDGPIALVLAPTRELAQQIQ 371

Human   262 QVADDYGKCSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGKTNLRRCTYLVLDE 326
            |||.::|..|.:::||::||||||.|:|||:||.||.|||||||||||.:|.|||:|||||||||
  Fly   372 QVATEFGSSSYVRNTCVFGGAPKGGQMRDLQRGCEIVIATPGRLIDFLSAGSTNLKRCTYLVLDE 436

Human   327 ADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYTQINVGNLELSANHNIL 391
            |||||||||||||||||.|||||||||||||||||||:|||||||.:|.|||:|:|||||||||.
  Fly   437 ADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVKQLAEDFLGNYIQINIGSLELSANHNIR 501

Human   392 QIVDVCMESEKDHKLIQLMEEI--MAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQ 454
            |:||||.|..|:.||..|:.:|  .:|...|.|||||||||.|:|.|.:|..|.....|||||||
  Fly   502 QVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLVRFIRSFGVRCGAIHGDKSQ 566

Human   455 PERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAY 519
            .|||:||.||||||:.||:|||||:|||||:.:|:|||:|||.:||||:||||||.||..|||::
  Fly   567 SERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQNSEDYIHRIGRTGRSNTKGTSF 631

Human   520 TFFTPGNLKQARELIKVLEEANQAINPKLMQLVDHRGGGGGGGKGGRSRYRTTSSANNPNLMYQD 584
            .|||..|.|||:.|:.||.||||.|||.|..|..:....||   ||||||
  Fly   632 AFFTKNNAKQAKALVDVLREANQEINPALENLARNSRYDGG---GGRSRY--------------- 678

Human   585 ECDRRLRGVKDGGRRDSASYRDRSETDRAGYANGSGYG 622
                  .|...|||.....::..|.::..|:..|.|.|
  Fly   679 ------GGGGGGGRFGGGGFKKGSLSNGRGFGGGGGGG 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX17	NP_001091974.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..115		19/47 (40%)
		DEAD-like_helicase_N	111..581	CDD:475120	294/473 (62%)
		Q motif	171..199		9/27 (33%)
		DEAD box	325..328		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	661..731
		Interaction with YAP1. /evidence=ECO:0000269|PubMed:24581491	720..728
Rm62	NP_524243.2	DEAD-like_helicase_N	231..669	CDD:475120	283/439 (64%)