Protein Alignment DDX17 and CG6418

DIOPT Version :10

• Sequence 1: NP_001091974.1
• Gene: DDX17 / 10521
• HGNCID: 2740
• Length: 731
• Species: Homo sapiens
• Sequence 2: NP_648413.1
• Gene: CG6418 / 39218
• FlyBaseID: FBgn0036104
• Length: 791
• Species: Drosophila melanogaster
• Alignment Length: 731
• Identity: 249/731 - (34%)
• Similarity: 356/731 - (48%)
• Gaps: 124/731 - (16%)

Human    30 DSASERE--------SAAPAAAPTA----------EAPPPSVVTRPEPQALPSPAIRAPLPDLYP 76
            |...|:|        ..:|.|.||:          |.|....:.....|.......:||.|   |
  Fly    97 DEPREKEIEQAYIPAPGSPGAPPTSAKKQEDSDSDEDPLEQFMAGINQQVEKEKRQQAPKP---P 158

Human    77 FGTMRGGGFGDRDRDRDRGGF----------GARGGGG---LPPKKFGNPGERLRKKKWDLSELP 128
            ...:|    ||.|.:.|...:          |.|..|.   :...:.|||....:||  |:..||
  Fly   159 TQAVR----GDIDDEDDEESYYRYMKENPNAGLRDEGSDQEIEYDEDGNPIAPPKKK--DIDPLP 217

Human   129 ----------KFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFPQYVM 183
                      .||||||.:|.::|.|...:|.||||...:.|.|... ||||.:|.|..|.:.::
  Fly   218 PIYHSEIEYEPFEKNFYTQHDDIAALDDEQVRELRRTLGVKVTGPSP-PKPVTSFGHFGFDEQLI 281

Human   184 DVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICL 248
            ..:....:|:|||||.|..|.||||||::|||:||||||.|::.|.::|:..|..|:.|||||.|
  Fly   282 KAVRKAEYTQPTPIQAQAVPTALSGRDIIGIAKTGSGKTAAFIWPMLMHVMDQKQLKPGDGPIGL 346

Human   249 VLAPTRELAQQVQQVADDYGKCSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGK 313
            :|||||||:.|:...|..:||...|...|.|||..|..|.:.||:|.||.:|||||:||.::...
  Fly   347 ILAPTRELSLQIYNEAKKFGKVYNLNVVCCYGGGSKWEQSKALEQGAEIIVATPGRMIDMVKMKA 411

Human   314 TNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYTQIN 378
            |||||.|:|||||||||..||||||:|.|.:.:|||||.||:|||:.|.:.:||.|.|.|..:|.
  Fly   412 TNLRRVTFLVLDEADRMFHMGFEPQVRSICNHVRPDRQCLMFSATFKKRIERLARDVLSDPVRIV 476

Human   379 VGNLELSANHNILQIVDVCMES-EKDHKLIQLMEEIMAEKENKTIIFVETKRRCDDLTRRMRRDG 442
            .|:|. .||.:|.|.|.|.... :|.:.|:..:.:.::  |...:|||..|...:.::..:....
  Fly   477 QGDLN-EANQDITQSVYVFPNPLQKWNWLLCHLVKFLS--EGSVLIFVTKKVDAETVSNNLLIKE 538

Human   443 WPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIG 507
            :..:.:|||..|.:|:.|:.:|:..:..||:|||||:||||:..::.|:|||.....|.:.||||
  Fly   539 YNCLLLHGDMDQADRNKVITQFKRKECDILVATDVAARGLDIPHIRNVVNYDTARDIETHTHRIG 603

Human   508 RTARSTNKGTAYTFFTPGNLKQARELIKVLEEANQAINPKLMQLV-------------------- 552
            ||.|:..||.|||..|..:.:.|..|::.||.|:|.:...||:|.
  Fly   604 RTGRAGEKGNAYTLVTDKDKEFAGHLVRNLEGADQLVPDDLMELAMKSSWFRSSRFKQGKGKRPT 668

Human   553 -DHRG--------GGGGGGKGGRSRYRTTSSANNPNLMYQDECDRRLRGVKDGGRRDSASYRDRS 608
             .|.|        ||||.|..|.|....:.||::|:                .|....|......
  Fly   669 NTHTGLGYREKGNGGGGYGSAGGSESTASVSAHSPS----------------DGPSSKAFSSSGP 717

Human   609 ETDRAGYANGSGYGSPNSAFGAQAGQYTYGQGTYGAAAYGTSSYTAQEYG----------AGTYG 663
            .|||        |.:...||.:|.      ...:.|::..|...|..|.|          :.|.|
  Fly   718 ATDR--------YTAMREAFRSQY------NNQFRASSDRTWEKTLPESGVFAAPMAPPSSSTQG 768

Human   664 ASSTTSTGRSSQSSSQ 679
            ||::::...|:|.:.:
  Fly   769 ASASSANNSSNQDAKR 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX17	NP_001091974.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..115		25/115 (22%)
		DEAD-like_helicase_N	111..581	CDD:475120	207/509 (41%)
		Q motif	171..199		8/27 (30%)
		DEAD box	325..328		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	661..731		6/19 (32%)
		Interaction with YAP1. /evidence=ECO:0000269|PubMed:24581491	720..728
CG6418	NP_648413.1	SrmB	269..634	CDD:440279	160/367 (44%)