Protein Alignment DDX17 and CG10077

DIOPT Version :10

• Sequence 1: NP_001091974.1
• Gene: DDX17 / 10521
• HGNCID: 2740
• Length: 731
• Species: Homo sapiens
• Sequence 2: NP_648062.2
• Gene: CG10077 / 38756
• FlyBaseID: FBgn0035720
• Length: 818
• Species: Drosophila melanogaster
• Alignment Length: 793
• Identity: 366/793 - (46%)
• Similarity: 439/793 - (55%)
• Gaps: 165/793 - (20%)

Human    69 APLPDLYPFG-------TMRGGG-----FGDRDRDRDRGGFGARGGGGLPPKKFGNPGERLRKKK 121
            ||.|.....|       .|.|||     .|.|::|    |||.:.||    ::..|.|..|.|..
  Fly    52 APYPGFNGHGPANGGQRRMNGGGPSMGPGGPRNQD----GFGGQNGG----QRSSNHGAHLPKIV 108

Human   122 WDLSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFPQYVMDVL 186
            |....|..|.||||.....|...|..|.:......|||:: ||..|.|...|....||.|||:.:
  Fly   109 WSEVNLTPFRKNFYKPCDSVLARTVGETETFLTSNEITIK-GDQVPTPSIEFEEGGFPDYVMNEI 172

Human   187 MDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLA 251
            ..|.|.:||.||.||:|:|:||||:||:|||||||||||:|||:||||:||.||||||||.||||
  Fly   173 RKQGFAKPTAIQAQGWPIAMSGRDLVGVAQTGSGKTLAYVLPAVVHINNQPRLERGDGPIALVLA 237

Human   252 PTRELAQQVQQVADDYGKCSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGKTNL 316
            ||||||||:||||.::|..:.:::|||:||||||.|.|||||||||.||||||||||||.|.|:|
  Fly   238 PTRELAQQIQQVAIEFGSNTHVRNTCIFGGAPKGQQARDLERGVEIVIATPGRLIDFLERGTTSL 302

Human   317 RRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYTQINVGN 381
            :|||||||||||||||||||||||||:.|||||||.||||||||||||||||:||.:|.|:|:|:
  Fly   303 KRCTYLVLDEADRMLDMGFEPQIRKIMQQIRPDRQVLMWSATWPKEVRQLAEEFLNNYIQVNIGS 367

Human   382 LELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKENKTIIFVETKRRCDDLTRRMRRDGWPAM 446
            |.||||||||||||||.|:||..|||:|:.:|.||.|.|||||||||:|.|::||.:.|.||.|.
  Fly   368 LSLSANHNILQIVDVCDENEKLMKLIKLLTDISAENETKTIIFVETKKRVDEITRNISRQGWRAC 432

Human   447 CIHGDKSQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTAR 511
            .|||||||.|||:||:.||:|:..||:|||||:|||||:|||||||||||::|||||||||||.|
  Fly   433 AIHGDKSQQERDFVLSSFRNGRHSILVATDVAARGLDVDDVKFVINYDYPSNSEDYVHRIGRTGR 497

Human   512 STNKGTAYTFFTPGNLKQARELIKVLEEANQAINPKLMQLV-----DHRGGGGGGGKGGRSRYRT 571
            |.|.|||||.||..|..:|.:||:||.||||.||||||.:.     :.||||.|||..|.:.|:
  Fly   498 SNNTGTAYTLFTHSNANKANDLIQVLREANQTINPKLMNMAMNGGYNKRGGGMGGGYRGGNGYQ- 561

Human   572 TSSANNPNLMYQDECDRRLRGVKDGGRRDSASYRDR----SETDRAGYANGSGYG------SPNS 626
               ..||.:              .||.....:||:.    :..:|..:..||..|      .|.:
  Fly   562 ---GRNPQM--------------GGGYNGGNNYRNNNGPGATMNRNSFNGGSAGGPPRFDQKPRT 609

Human   627 AFGAQAGQYTY-GQGTYGAAAYGTSSYTAQEYG-------------------------------- 658
            :...|.||..| |||  |....|......|:.|
  Fly   610 SPPNQGGQGGYRGQG--GGGYQGQQQQQQQQNGGVPFSRFNPNAACFEPNKPQNGPGSGPPQAQH 672

Human   659 -------------------------AGTYGASSTTS---------TGRSSQSSSQQFSGIGRSGQ 689
                                     |..||.....|         ......:.:||.:...:..|
  Fly   673 QQQQQAQAAQQQHLLPDASVQAAMTAANYGVDQKRSRFSPYNMNFANMPPPAMNQQQAAAAQQQQ 737

Human   690 Q-----PQPLMSQQFAQPPGA----------------------------------TNMIGYM--- 712
            |     ||....||..|.|.|                                  |....||
  Fly   738 QQQLQTPQQQQQQQQMQQPQAYGQYSSMSSSMATVSLNGGAAAVASSYRAPYAVPTQAAPYMMAN 802

Human   713 GQTAYQYPPPPPP 725
            |...:.|||||.|
  Fly   803 GGDIFAYPPPPLP 815

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX17	NP_001091974.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..115		17/57 (30%)
		DEAD-like_helicase_N	111..581	CDD:475120	305/474 (64%)
		Q motif	171..199		11/27 (41%)
		DEAD box	325..328		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	661..731		24/116 (21%)
		Interaction with YAP1. /evidence=ECO:0000269|PubMed:24581491	720..728		5/6 (83%)
CG10077	NP_648062.2	DEAD-like_helicase_N	49..544	CDD:475120	310/500 (62%)