Protein Alignment DDX17 and CG10333

DIOPT Version :10

• Sequence 1: NP_001091974.1
• Gene: DDX17 / 10521
• HGNCID: 2740
• Length: 731
• Species: Homo sapiens
• Sequence 2: NP_609888.2
• Gene: CG10333 / 35112
• FlyBaseID: FBgn0032690
• Length: 822
• Species: Drosophila melanogaster
• Alignment Length: 639
• Identity: 207/639 - (32%)
• Similarity: 302/639 - (47%)
• Gaps: 164/639 - (25%)

Human    27 ATGDSASERESAAP------AAAPTAEAPPPSVVTRPEPQALPSPAIRAPLPDLYPFGTMRGGGF 85
            |..|:|.|:.:||.      ..|..:.||||::|..|            |.||    ...||||
  Fly   173 AAHDAAREQMAAASKVSISMGTAMASGAPPPAIVAPP------------PKPD----RRERGGG- 220

Human    86 GDRDRDRDRGGFGARGGG-----------------------GLPPKKFGNPGERLRKKK----WD 123
              |||. ||...|.||..                       |:..||  ....||..:|    ||
  Fly   221 --RDRG-DRIDRGERGDDKRAEDLTHKDKEKELEAIRERYLGIIKKK--RRVRRLNDRKFVFDWD 280

Human   124 LSELPKFE-KNFYVEHPEV-----------------------------ARLTPYEVDE------- 151
            ..|....: .|.|.|...|                             .|.|..|.::
  Fly   281 AGEDTSIDYNNLYKERHHVQFFGRGNVAGIDIKEQKRTQSKFYGDLLEKRRTEAEKEQEKVRLKK 345

Human   152 LRRKKE------------------------------ITVRGGDVCPKPVFAFHHANFPQYVMDVL 186
            ::||::                              :|::||.: |.|:.:::.:.||:.::|::
  Fly   346 MKRKEDKQKWDDRHWSEKENDEMTERDWRIFREDYNVTIKGGRI-PNPIRSWNESGFPKEIIDII 409

Human   187 MDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLER----GDGPIC 247
            ....:.||||||.|..|:.|..||::|:|:||||||||:|:|.:..|...|.:||    ..||..
  Fly   410 DKVGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTLAFLIPLLSWIQSLPKIERLEDVDQGPYA 474

Human   248 LVLAPTRELAQQVQQVADDYGKCSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESG 312
            :::|||||||||:::....:|:...:::..:.||..:..|...|..|.||.|||||||||.||:.
  Fly   475 IIMAPTRELAQQIEEETTKFGQPLGIRTVVVVGGLSREEQGFRLRLGCEIVIATPGRLIDVLENR 539

Human   313 KTNLRRCTYLVLDEADRMLDMGFEPQIRKI-----VDQIRPD--------------------RQT 352
            ...|.:|||:||||||||:||||||.::||     |..::||                    |||
  Fly   540 YLVLNQCTYIVLDEADRMIDMGFEPDVQKILEYMPVTNLKPDTEEAEDETKLMENFYTKKKYRQT 604

Human   353 LMWSATWPKEVRQLAEDFLRDYTQINVGNLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEK 417
            :|::||.|..|.:||..:||....:.:|::. .......|||.:..|::|..||:    ||::.|
  Fly   605 VMFTATMPPAVERLARTYLRRPATVYIGSVG-KPTERTEQIVYMMGENDKRKKLM----EILSRK 664

Human   418 -ENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRG 481
             :...||||..|:..|.|.:.:.:.|:.:..:||.|.|.:|::.|...:||...||:|||||.||
  Fly   665 IDPPVIIFVNQKKGADVLAKGLEKLGYNSCTLHGGKGQEQREYALAALKSGAKDILVATDVAGRG 729

Human   482 LDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPG------NLKQ 529
            :|::||..|||||...:.|||.||||||.|:...|.|.:|.|..      :|||
  Fly   730 IDIKDVSLVINYDMAKTIEDYTHRIGRTGRAGKTGCAISFVTKDDSALFYDLKQ 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX17	NP_001091974.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..115		31/116 (27%)
		DEAD-like_helicase_N	111..581	CDD:475120	176/526 (33%)
		Q motif	171..199		8/27 (30%)
		DEAD box	325..328		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	661..731
		Interaction with YAP1. /evidence=ECO:0000269|PubMed:24581491	720..728
CG10333	NP_609888.2	DUF5401	<66..354	CDD:375164	46/202 (23%)
		SrmB	395..783	CDD:440279	154/392 (39%)