Protein Alignment DDX17 and Prp5

DIOPT Version :10

• Sequence 1: NP_001091974.1
• Gene: DDX17 / 10521
• HGNCID: 2740
• Length: 731
• Species: Homo sapiens
• Sequence 2: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Alignment Length: 756
• Identity: 251/756 - (33%)
• Similarity: 362/756 - (47%)
• Gaps: 135/756 - (17%)

Human    15 PSPTREAATVASATGDSASERESAAPAAAPTAEAPPPSVVTRPEPQALPSPAIRAPLPDLY---- 75
            |.|......:......:|.|:....|..........|.|..:|:|:|.|...| .|| |.|
  Fly   321 PEPVAAKMEIVEEPTVAAGEKTKKEPEQPHVGAKSEPEVEDKPQPEAEPEDEI-DPL-DAYMQEV 383

Human    76 -----------------------------PFGTMRGGGFGDRDRD-------------RDRGGFG 98
                                         ...|::.|...:::.|             ||..
  Fly   384 NNEMRRVNNFVNPPAKSQGVVILTGVAKKKTTTLKKGEVIEQNMDSLEYSSEDELEDIRDTA--- 445

Human    99 ARGGGGLPPKKFGNPGERLRKK--KWDLSEL--PKFEKNFYVEHPEVARLTPYEVDELRRKKE-I 158
                        .|...:.||:  |.|.|.:  ..|.||||||.||:.|:|..:|::.|...| |
  Fly   446 ------------VNLAMKHRKELAKIDHSSVTYAPFRKNFYVEVPELTRMTAADVEKYRSDLEGI 498

Human   159 TVRGGDVCPKPVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTL 223
            .|:|.. ||||:..:......:..|:||....|.:|||||||..|..:||||::|||:|||||||
  Fly   499 QVKGKG-CPKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGRDLIGIAKTGSGKTL 562

Human   224 AYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQQVADDYGKCSRLKSTCIYGGAPKGPQI 288
            |::||...||..||.:|.|||.|.:::||||||..|:.:....:.|...|:..|:|||.....||
  Fly   563 AFILPMFRHILDQPSMEDGDGAIAIIMAPTRELCMQIGKDIRKFSKSLGLRPVCVYGGTGISEQI 627

Human   289 RDLERGVEICIATPGRLIDFL--ESGK-TNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDR 350
            .:|:||.||.:.||||:||.|  .||: |||||.||:||||||||.|||||||:.:|:|.:||||
  Fly   628 AELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIIDNVRPDR 692

Human   351 QTLMWSATWPKEVRQLAEDFLRDYTQINVGNLELSANHNILQIVDVCMESEK-------DHKLIQ 408
            ||:|:|||:|:::..||...|:...::.||...:           ||.|.|:       |.|..:
  Fly   693 QTVMFSATFPRQMEALARRILKKPIEVIVGGRSV-----------VCKEVEQHVVILNDDAKFFK 746

Human   409 LMEEI-MAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPIL 472
            |:|.: :.::....|:||:.:...|.|.|.:.:..:|.|.:||...|.:||..:.:|:|||..:|
  Fly   747 LLELLGIYQEAGSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDSTIIDFKSGKVRLL 811

Human   473 IATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELIKVL 537
            |||.||:|||||:|:..|:|||.||..||||||.|||.|:..||:||||.||...:.|.::|:.:
  Fly   812 IATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQSRYAGDIIRAM 876

Human   538 EEANQAINPKLMQL-VDHRG-----------GGGGGGKGGRSRYRTTSSANNPNLM--------- 581
            :.:...|..:|..| .:::.           |||..|||.:...:..::|.....:
  Fly   877 DLSGTLIPAELQALWTEYKALQEAEGKTVHTGGGFSGKGFKFDEQEFNAAKESKKLQKAALGLAD 941

Human   582 ------YQDECDRRL-------RGVKDGGRRDSASYRDRSETDRAGYANGSGYGSPNSAFGAQAG 633
                  .:.:.|:::       |.|||    .||:....:....|..|..:.....|.|..:.|.
  Fly   942 SDDEEDIEQDIDQQIEQIFAAKRTVKD----TSAAATAAAAAAAAAAAAAAAVSGANPALASAAA 1002

Human   634 QYTYGQGTYGAAAYGTSSYTAQEYGAGTYGASSTTSTGRSS 674
            |      ...|||....:..|....|...||.|....|..|
  Fly  1003 Q------AAAAAAAANIAIAAASAPAAAGGAPSVAMGGALS 1037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX17	NP_001091974.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..115		20/140 (14%)
		DEAD-like_helicase_N	111..581	CDD:475120	207/497 (42%)
		Q motif	171..199		8/27 (30%)
		DEAD box	325..328		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	661..731		5/14 (36%)
		Interaction with YAP1. /evidence=ECO:0000269|PubMed:24581491	720..728
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653	16/63 (25%)
		DEAD-like_helicase_N	454..899	CDD:475120	198/456 (43%)
		KH-I_DDX46	1121..1223	CDD:411901