Protein Alignment DDX17 and mahe

DIOPT Version :10

• Sequence 1: NP_001091974.1
• Gene: DDX17 / 10521
• HGNCID: 2740
• Length: 731
• Species: Homo sapiens
• Sequence 2: NP_572424.1
• Gene: mahe / 31707
• FlyBaseID: FBgn0029979
• Length: 945
• Species: Drosophila melanogaster
• Alignment Length: 712
• Identity: 338/712 - (47%)
• Similarity: 424/712 - (59%)
• Gaps: 95/712 - (13%)

Human    78 GTMRGGGF-GDRDRD--------RDRGGFGARGG-------------------GGLPPKKFGNPG 114
            |:...||: |.|.::        :...|.|..||                   ..:..:|..|||
  Fly   119 GSGGSGGYGGQRGKNPTYAQRYQKPNNGAGVAGGYQSNNYNAAALGMLSKEERAEIQREKAKNPG 183

Human   115 ERLRKKKWDLSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFP 179
            ..|.|.||:  .|..|.|:||..||.....:..:|.|:||:.||||.|.:: |.||.:|..::.|
  Fly   184 RNLVKPKWE--NLEPFLKDFYNIHPNTLAKSEQQVAEIRRELEITVSGNEL-PHPVVSFEESSLP 245

Human   180 QYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDG 244
            .:|::.:..|.||:||.||.||:|:||||||:||||||||||||||:|||||||.:||.:.||:|
  Fly   246 AHVIEEMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHIGNQPPIIRGEG 310

Human   245 PICLVLAPTRELAQQVQQVADDYGKCSR--LKSTCIYGGAPKGPQIRDLERGVEICIATPGRLID 307
            ||.||||||||||||:|.|..|||...:  ::.|||:||:.|.||.|||:||||:.|||||||||
  Fly   311 PIALVLAPTRELAQQIQSVVRDYGHLCKPEIRHTCIFGGSSKVPQARDLDRGVEVIIATPGRLID 375

Human   308 FLESGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLR 372
            |||:..|||:|||||||||||||||||||||||||::|||||||.:||||||||||:.||.|||.
  Fly   376 FLENRNTNLQRCTYLVLDEADRMLDMGFEPQIRKIIEQIRPDRQVVMWSATWPKEVQALAGDFLN 440

Human   373 DYTQINVGNLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKE-----NKTIIFVETKRRCD 432
            ||.|||:|::.|||||||.|||::|.|.||..:|:.|:.||...|.     ||.|:|||||.:.:
  Fly   441 DYIQINIGSMNLSANHNIRQIVEICTEIEKPQRLVCLLNEISPIKNSGNNGNKIIVFVETKIKVE 505

Human   433 DLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPN 497
            |:.:.:|.:|:.|..|||||:|.|||.||.:||:||:.||||||||||||||||:::||||||||
  Fly   506 DILQIIRAEGYNATSIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDVEDLQYVINYDYPN 570

Human   498 SSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELIKVLEEANQAINPKLMQLVDHRGGGGGGG 562
            |||:||||||||.|....|||||||||.|.|||||||.|||||.|..:..|:.|.  |.....||
  Fly   571 SSENYVHRIGRTGRCQQLGTAYTFFTPDNAKQARELISVLEEAGQTPSQALLDLA--RSMPSSGG 633

Human   563 KGGRSRYRTTSSANNPNLMYQDECDRRLRGVKDGGRRDSASYRDRSETDRAGYANGSGYGSPNSA 627
            ..|..|:...|..           ||...|       ::..|:.|: .:...|..|:.|.:..|.
  Fly   634 YRGNKRWNNNSGG-----------DRNTGG-------NNGIYQQRN-NNPLNYQAGNNYNNNRSG 679

Human   628 --FGAQAGQYTYGQGTY------GAAAYGTSSYTAQEYGAG-------TYGASSTTSTGRSSQSS 677
              .|:...||..|..||      |...:...:...|:.|||       ||...:..:.|......
  Fly   680 PPTGSSYQQYAAGGNTYLQNGAGGGVNWNRMNQMGQDGGAGQQQRNGNTYRPRAPFNNGGPRAIM 744

Human   678 SQQFSGIGRSGQQ-----PQPLMS-QQFAQ-------------PPGATNMIGYMGQTAYQYP 720
            ..|..|:|..|..     ||.||: ||..|             |.||.  .|.|.....|||
  Fly   745 GHQGGGVGAGGAAGVGGGPQQLMAPQQGGQYMPQAYRGRSQFVPQGAG--AGGMPPRFQQYP 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX17	NP_001091974.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..115		12/64 (19%)
		DEAD-like_helicase_N	111..581	CDD:475120	286/476 (60%)
		Q motif	171..199		9/27 (33%)
		DEAD box	325..328		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	661..731		22/79 (28%)
		Interaction with YAP1. /evidence=ECO:0000269|PubMed:24581491	720..728		1/1 (100%)
mahe	NP_572424.1	DEAD-like_helicase_N	136..656	CDD:475120	294/542 (54%)