Protein Alignment FBXW10 and UFO1

DIOPT Version :10

• Sequence 1: XP_047291077.1
• Gene: FBXW10 / 10517
• HGNCID: 1211
• Length: 1103
• Species: Homo sapiens
• Sequence 2: NP_013622.1
• Gene: UFO1 / 854886
• SGDID: S000004553
• Length: 668
• Species: Saccharomyces cerevisiae
• Alignment Length: 736
• Identity: 145/736 - (19%)
• Similarity: 234/736 - (31%)
• Gaps: 247/736 - (33%)

Human   282 DLDDIRDLSSGFSKYRDFIRYLPIHLSKYILSMLGCMRGFPRHLPSWPSSGVSGSIFFFPGMLDR 346
            ||..:::||:.|...        || .:.:...|...|....|.|::..|. ..|:.:.......
Yeast    27 DLFTLQELSTHFRNL--------IH-DEELWKNLFKSRVHTTHFPTFSQSS-KFSVEYIERTRGL 81

Human   347 HTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMV--DD 409
            |          ||    |..|.       |:.:.|.:.   ||..|.....::....|::.  :|
Yeast    82 H----------HW----QHNKA-------IRTKYTIIP---TRNWDQPSIERIVFDYPRVAAYND 122

Human   410 GKSMRVK---HPKWKLRTKNEYNLWTAYQNEETQQVLIEERNVFCGTYNVRILSDTWDQNRVIHY 471
            |....::   |.:.|...|..|...|..|...|....|... || |.::.|:.
Yeast   123 GTITILQLQNHKRQKKFKKLIYIPCTTPQGCSTMDFNINAA-VF-GRFDGRVF------------ 173

Human   472 SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRG-HAGSVRALFLCEEENFLLSGSYDLSIRYWDLKS 535
              |.|:    :.|.:|..:       :||.| |:..|.|  :|..|      |:|.|...|.
Yeast   174 --GKLL----SNKSYLTPV-------MEFTGRHSAGVTA--ICNSE------SWDTSREDWS--- 214

Human   536 GVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRINDTYIVS 600
                 :.|...|.|...  |:|:|        ||:|.|......|....||..|.......||:.
Yeast   215 -----VSGSENGEIIWW--CENKL--------VKMWKVSNRVIWKLAFFKDWTLIMDDEKLYIIH 264

Human   601 SCER------------------------GLVKVWHIAMAQL--VKTLS----GHEGAVKCLFFDQ 635
            ..:.                        |.:.   :.:|.|  |.|:|    |:.|.::.|...:
Yeast   265 QMQELHSIDIPKDLDEQPMRVRFFKMDFGSMT---LVLADLNNVYTISVNPNGNFGNLRKLEMPE 326

Human   636 -----------------WHLLSGSTDGLVMA---------------WSMVGKYERCLMAFKHPKE 668
                             |..  ...||..::               .|..|...:|.::|.....
Yeast   327 QICAVEIDEKTSQREQNWQF--AGDDGCYISLLTTQNTLYIINIRDLSSSGLKVQCKISFDEQVY 389

Human   669 VLDVSLLFLRVISACADGKIRIYNFLNGNCMK-VLKAN---------------GRGDPVLSF--F 715
            |..|:.|   ::.......::|.|.:.|..:| |||..               |.|: ||::  |
Yeast   390 VSQVTNL---IVVVALPNVLQILNAMTGELIKTVLKTEKFPEFLKVSQDKIIMGSGN-VLNYLKF 450

Human   716 IQGNRMV-------VNTESNVLMFQFEHIKW--------QYAVEKTKQKKNKEKE---------- 755
            :..:...       .||.||         ||        ||..|....::.::.|
Yeast   451 VSSDSKKHHHSTKGKNTVSN---------KWNETLNTELQYYDEDEDLRRKRQSEISRLIDAYGG 506

Human   756 ------EEKEENSLMEILSKCNIQVHSPRESVSSKQTV---IQELLPGKPPKSRVLLKPAKFSSA 811
                  :..|||.:...::....|....|....:.:.|   ..|.|.....:|:::.:....|||
Yeast   507 DLELSGDTDEENDIQLRIALLESQEAQARNQAEAGEPVGDDEDEQLRRALEESQLIYETQTNSSA 571

Human   812 VLIEELQSQGKSKSPRRDADDVE--KAQKQGQLETPGK--LPSHPKKKSWKIPMSPDQFLLTVSA 872
                   :.|.:.:...|.||.|  :|.:|.::|...:  |.:|...:. ..|:|.|.|     |
Yeast   572 -------NHGNNTNDEIDEDDEEFLRAIRQSRVEDERRRHLRNHTTGRR-NGPLSDDNF-----A 623

Human   873 LQHAHNSGEFAYPCRPQTEIT 893
            ...|..|.|     |..||.|
Yeast   624 TYGAAESSE-----RTSTENT 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FBXW10	XP_047291077.1	F-box_SF	299..367	CDD:459239	12/67 (18%)
		WD40	469..704	CDD:238121	57/298 (19%)
		WD40 repeat	508..544	CDD:293791	7/35 (20%)
		WD40 repeat	549..583	CDD:293791	9/33 (27%)
		WD40 repeat	589..622	CDD:293791	8/58 (14%)
		WD40 repeat	628..664	CDD:293791	7/67 (10%)
		WD40 repeat	672..703	CDD:293791	7/31 (23%)
UFO1	NP_013622.1	F-box_ScUFO1-like	6..46	CDD:438916	7/27 (26%)